chapter 14 Flashcards
What is happening as naive lymphocytes circulate between the tissues and the blood?
lymphocytes constantly scan for Ag to which it can respond
Lymphocytes exit blood by extravasating at _____________________
high-endothelial venules (HEVs)
movement of blood cells (leukocytes) through an unruptured vessel wall into the surrounding tissue, particularly at sites of inflammation
extravasation
What is extravasation driven by?
sequential activation of surface molecules
What is L-selectin?
-adhesion molecule expressed on naive lymphocytes
-Contact allows the cells to slow down and roll along the vessel walls
-Further interactions with other adhesion molecules stop the cells and
allow them to squeeze through junctions between the cells
Naive lymphocytes browse for antigen along _________________in the lymph node.
reticular networks
______________are first responders to chemokine attraction producing more chemokines that attract APCs and DCs.
neutrophils
B cells bind _______________________ in lymph node.
unprocessed Ag
T cells scan lymph node for _________________________bound to MHC molecules.
Ag peptides
Where do B cells seek help from CD4 T cell?
at the border between the follicle and paracortex of the lymph node
Naive CD8 T cells differentiate early in activation but require _____________________help to generate memory cells
CD4 T cell help
There is a three-cell interaction between what three cells simultaneously?
APC binding to CD8 and CD4 T cells
what happens after effector cells have proliferated and differentiated?
they leave
early IgM producers move to the ___________________of the lymph node?
medulla
IgG producers often move to ___________________.
bone marrow
IgA producers localize to_____________________ especially at the gut.
MALT
Effector and memory T cells travel to multiple organs and sites of
infection by following ________________________.
chemokine cues
The immune response contracts within how many days?
10 to 14
After Ag is removed, most lymphocytes are no longer
required and will be induced to undergo ____________________.
apoptosis
