Chapter 13 Flashcards

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1
Q

Alzheimer’s Disease

A

Condition characterized by memory loss, confusion, depression, restlessness, hallucinations, delusions, sleeplessness and loss of appetite. 5% of people age 65-74 and 50% over 80. Amyloid-B accumulates inside and outside neurons, causing dendrite damage, decrease in synaptic input and decreased plasticity. Damaged dendrites accumulate into plaques and cerebral cortex, hippocampus and other areas atrophy.

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2
Q

Amnesia

A

memory loss

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3
Q

Amyloid-B

A

A protein that accumulates to higher than notmal levels in patients with Alzhaimer’s disease

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4
Q

Anteretrograde amnesia

A

Inability to for memories for events that happened after brain damage

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5
Q

AMPA receptor

A

a glutamate receptor that can respond to AMPA - when stimulated enables glutamate to stimulate nearby NMDA receptors also, allowing calcium into the cell where a series of changes potentialte the dendrite’s future responsiveness to glutamate at the AMPA receptor.

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6
Q

associativity

A

a weak input paired with a stronger input enhances its later response

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7
Q

BDNF

A

Brain derived neurotrophin factor - a neurotrophin similar to NGF

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8
Q

cooperativity

A

tendency for nearly simultateous stimulation by 2 or more axons to produce long-term potentiation much more effectively than stimulation by just one

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9
Q

classical conditioning

A

type of conditioning produced by the pairing of two stimuli, one of which evokes automatic response

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10
Q

conditioned stimulus (CS)

A

Stimulus that evokes a particular response only after it has been paired with an unconditioned stimulus

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11
Q

conditioned response (CR)

A

response evoked by a conditioned stimulus after it has been paired with an unconditioned stimulus

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12
Q

confabulation

A

a distinctive symptom of Korsakoff’s syndrome in which patients fill in memory gaps with guesses

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13
Q

consolidation

A

to strengthen a memory and make it more long lasting

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14
Q

declarative memory

A

deliberate recal of information that one recognizes as memory (explicit memory)

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15
Q

delayed matching-to-sample task

A

task in which an animal sees a sample object and then after a delay must choose an object that matches the sample

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16
Q

delayed nonmatching-to-sample task

A

task in which an animal sees a sample object and then after a delay must choose an object that does not match the sample

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17
Q

delayed response task

A

assignment in which an animal must respond on the basis of a signal that it remembers but that is no longer present

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18
Q

engram

A

physical representation of what has been learned

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19
Q

episodic memory

A

memories of a single personal event

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20
Q

equipotentiality

A

concept that all parts of the cortex contribute equally to complex behaviours; any part of the cortex can substitute for any other

21
Q

explicit memory

A

deliberate recall of a memory that one recognizes as a memory (declarative memory)

22
Q

habituation

A

a decrease in response to a stimulus that is presented repeatedly and accompanied by no change in other stimuli

23
Q

Hebbian synapse

A

a synapse that increases in effectiveness beacuse of simultaneous activity in the pre- and postsynaptic neurons

24
Q

implicit memory

A

an influence of experience on behaviour, even if the influence is not recognized

25
Q

instrumental conditioning

A

(operant conditioning) a type of condition in which reinforcement or punishment changes the future probabilities of a given behaviour

26
Q

Korsakoff’s syndrome

A

(Wernicke-Korsakoff’s syndrome) brain damage caused by prolonged thymine deficiency, which causes an inability to metabolize glucose. Mostly in alcoholics. Causes loss or shrinkage of neurons, especially in dorsomedial thalamus (main source of input for prefrontal cortex).

27
Q

lateral interpositus nucleus (LIP)

A

a nucleus of the cerebellum that is essential for learning

28
Q

long-term memory

A

memory of events that occurred further back in time

29
Q

long-term depression

A

(LTD) a prolonged decrease in response at a synapse where the axons have been less active than certain other axons afferent to that neuron

30
Q

long-term potentiation

A

(LTP) phenomenon that when one or more axons connected to a dendrite bombard it with a rapid series of stimuli, some of the synapses become more responsive to new input of the same type for minutes, days or weeks

31
Q

mass action

A

concept that the cortex works as a whole and the more cortex, the better

32
Q

Morris water maze

A

a procedure used to test for spatial memory in nonhumans

33
Q

NMDA receptor

A

a glutamate receptor that can respond to drug NMDA. Response to glutamate depends on the degree of polarization across the membrane, as ion channels are usually blocked by Magnesium. When membrane depolarizes, magnesium leaves and sodiuma nd calcium rush in, facilitating changes that increase future responsiveness to glutamate at AMPA receptors.

34
Q

procedural memory

A

the development of motor skills and habits, a special kind of implicit memory

35
Q

punishment

A

an event that supresses frequency of the preceeding response

36
Q

radial maze

A

an apparatus used to test spatial memory in nonhumans

37
Q

retrograde transmitter

A

a transmitter released by a post synaptic cell that travels back to the presynaptic cell to modify it

38
Q

reconsolidation

A

restrengthening of a memory by a similar later experience

39
Q

reinforcer

A

any event that increases the future probability of the preceeding response

40
Q

retrograde amnesia

A

loss of memory for events that occurred before brain damage

41
Q

sensitization

A

an increase in response to mild stimuli as a result of exposure to more intense stimuli

42
Q

specificity

A

property that highly active synapses become strengthened and less active synapses do not

43
Q

semantic dementia

A

damage to anterior and inferior regions of temporal lobe experience semantic dementia - a loss of semantic memory

44
Q

short-term memory

A

memory of events that have just occurred

45
Q

tau protein

A

part of the intracellular support structure of axons - principally responsible for tangles (formed from degeneration within neurons). Works with amyloid-B in alzheimer’s.

46
Q

unconditioned response (UCR)

A

Response automatically evokes by an unconditioned stimulus

47
Q

unconditioned stimulus (UCS)

A

stimulus that automatically evokes an unconditioned response

48
Q

working memory

A

the way we store information while we are working with it