Chapter 13 Flashcards
Alzheimer’s Disease
Condition characterized by memory loss, confusion, depression, restlessness, hallucinations, delusions, sleeplessness and loss of appetite. 5% of people age 65-74 and 50% over 80. Amyloid-B accumulates inside and outside neurons, causing dendrite damage, decrease in synaptic input and decreased plasticity. Damaged dendrites accumulate into plaques and cerebral cortex, hippocampus and other areas atrophy.
Amnesia
memory loss
Amyloid-B
A protein that accumulates to higher than notmal levels in patients with Alzhaimer’s disease
Anteretrograde amnesia
Inability to for memories for events that happened after brain damage
AMPA receptor
a glutamate receptor that can respond to AMPA - when stimulated enables glutamate to stimulate nearby NMDA receptors also, allowing calcium into the cell where a series of changes potentialte the dendrite’s future responsiveness to glutamate at the AMPA receptor.
associativity
a weak input paired with a stronger input enhances its later response
BDNF
Brain derived neurotrophin factor - a neurotrophin similar to NGF
cooperativity
tendency for nearly simultateous stimulation by 2 or more axons to produce long-term potentiation much more effectively than stimulation by just one
classical conditioning
type of conditioning produced by the pairing of two stimuli, one of which evokes automatic response
conditioned stimulus (CS)
Stimulus that evokes a particular response only after it has been paired with an unconditioned stimulus
conditioned response (CR)
response evoked by a conditioned stimulus after it has been paired with an unconditioned stimulus
confabulation
a distinctive symptom of Korsakoff’s syndrome in which patients fill in memory gaps with guesses
consolidation
to strengthen a memory and make it more long lasting
declarative memory
deliberate recal of information that one recognizes as memory (explicit memory)
delayed matching-to-sample task
task in which an animal sees a sample object and then after a delay must choose an object that matches the sample
delayed nonmatching-to-sample task
task in which an animal sees a sample object and then after a delay must choose an object that does not match the sample
delayed response task
assignment in which an animal must respond on the basis of a signal that it remembers but that is no longer present
engram
physical representation of what has been learned
episodic memory
memories of a single personal event