Chapter 11: Immunotherapy

Question 1

Adaptive Immune System

Answer 1

Requires time for development
Immunological Memory
Cytokines
Recognizes specific peptides

Question 2

Macrophages

Answer 2

Innate Immune System

Activated by pro-inflammatory cytokines from necrotic cells
Reactive oxygen Species(ROS)
Phagocytosis and ADCC

Question 3

NK

Answer 3

Recognize non-self tumor cells expressing lower levels of histocompatability proteins
ADCC

Question 4

APCs

Answer 4

Antigen Presenting Cells

Question 5

APC Macrophage and DC

Answer 5

Recognize tumor associated antigens as foreign

Question 6

APC primed B cells

Answer 6

Antibodies against tumor antigens

ADCC

Question 7

APC Primed Tcx Cells

Answer 7

Recognize tumor antigens on transformed cells as NON-SELF

Cytotoxicity

Question 8

Cytotoxic T Cell Killing

Answer 8

Cancer cells often down-regulate MHC1 to avoid being killed

Question 9

B Cells

Answer 9

Produce specific antibodies for opsonization (flagging)

Question 10

ADCC

Answer 10

Antibody Dependent Cellular Cytotoxicity

Mainly macrophage and NK

Question 11

T Cells

Answer 11

Recognize non-self peptides in groove of MHC molecules on surface of cells

Question 12

Two ways tumor can be recognized by immune system

Answer 12

1. Altered Self Peptides

2. Over expression of MHC

Question 13

Innate Immune System

Answer 13

Quick Responders

Recognizes stress on cancer cells, pattern PAMPS, and abs on cells