Chapter 11 Hardy Weinberg and Mutations Flashcards
A somatic cell mutation that results in under-expression of multiple genes
A) Chromosomal addition B) Sex Chromosome Y-linked inversion C) Autosomal dominant reversion D) Sex Chromosome X-linked accumulation E) Chromosome deletion
E
A de-novo (new) gamete-cell mutation has which of the following characteristics?
A) All offspring are affected
B) One parent must be a carrier
C) Both parents must be carriers
D) The condition cannot be transmitted to progeny
E) The condition must be transmitted to male progeny
c
Once a spontaneous dominant mutation has occurred in the progeny of a cross, it will become phenotypically evident at what time?
A) When the affected individual mates with a sibling
B) When the affected individual mates with a cousin
C) When the affected individual mates with another affected individual
D) Immediately
E) Never
D
Which of the following are required for a population to be in genetic equilibrium?
A) No Mutation B) Survival of the Fittest C) No Natural Selection D) Migration E) Random Mating
A
C
E
Worldwide, gene ABCD has an “R” amino acid in its polypeptide at position 64. The mutations p.R64T (53% of Asians), p.R64G (51% Europeans) mean which of the following could be relevant/true?
A) At least two different population based wild types
B) A substantial number of individuals with a mutation
C) Migration-based wild types
D) Founder-based mutation selection
E) All of the above
A
Identical twins were separated at birth. 27 years later, they found each other and were surprised that both of them were 5’ 8” tall. This is an example of:
A) Environmental influence B) Natural selection C) Heritability D) Mutation selection E) Reproductive success
c
The portion of a phenotype that is caused by the environment is considered to be…
A) Heritable B) Transmittable C) Migrational D) Central E) None of the above
E
Disease A is autosomal recessive. A total of 36% of the study population of 100 people are affected. How many homozygous unaffected individuals are in the study population?
A) 16 B) 24 C) 36 D) 48 E) 60
D
Disease A is autosomal recessive. A total of 36% of the study population of 100 people are affected. How many carriers are in the study population?
A) 16 B) 24 C) 36 D) 48 E) 60
C
The mutation p.Leu231Thr indicates what?
A) The coding sequence at DNA bp 231 has been changed to a Threonine in a sequence\
B) The amino sequence at DNA bp 231 has been changed to a Threonine in a sequence
C) The amino acid at position 231 has been changed to a Leucine in a polypeptide
D) The amino acid at position 231 has been changed to a Threonine in a polypeptide
D
Which of the following can cause mutation in Humans?
A) Ionizing Radiation B) Microwaves C) Mutagenic Chemicals D) Transposable elements E) Spider bites
A
C
Which of the following sequences would result from the annotation c.72dupTA[3]? THINK CAREFULLY!
A) 5’ …AUCACUAUAUACAGAUA..3’ B) 5’ …ATCACTATACAGATA..3’ C) 3’ …ATCACTATACAGATA..5’ D) 5’ …ATCACTAATAATAACAGATA..3’ E) 5’ …ATCACTAUATTACAGAUA..3’
C
Which of the following conditions best describes this subjects OPA1 gene?
A) Hemizygous B) Consanguineous C) Heterozygous D) Homozygous E) All of the above
A
