Chapter 11- Fundamentals of nervous system and nervous tissue Flashcards
Main functions of the nervous system (3)
These functions can overlap or co-occur
- Sensory input
- Integration
- Motor output (motor response)
Sensory input function
Monitors changes that occur inside the body and outside the body. We have many receptors, usually for one specific sensation
Integration function
Processing and integration of input information- the nervous system decides what response to make. The brain decides what the input means
Motor response function
Nervous system activates effector organs to cause a response. The brain or spinal cord sends a message based on the input.
Neuroglia (glial cells)
Provide support and maintenance to neurons
Neurons
Nerve cells that can respond to stimuli and transmit electrical signals. They can change membrane potential in a fraction of a second, which creates a message.
Neurons are the functional unit of the nervous system
What organs make up the central nervous system?
Brain and spinal cord
Central nervous system function
Function- is responsible for interpreting sensory input and deciding motor output
What is the peripheral nervous system composed of?
Composed of bundles of nerves coming from the brain/spinal cord
Peripheral nervous system function
Function- spinal nerves and cranial nerves link the rest of the body to the central nervous system. If a nerve is severed, that part of the body no longer exists to your brain
2 subdivisions of the peripheral nervous system
- Afferent division
2. Efferent division
Afferent division (PNS)
Carries impulses from the body to the central nervous system. Impulses allow the CNS to interpret information and send out a response.
Impulses from this division arrive at the brain
Efferent division (PNS)
Carries impulses from the CNS to the effector organs. Impulses activate muscle or glands to carry out motor response.
Impulses from this division exit the brain
Types of neuroglia (glial cells) in the CNS (4)
- Astrocytes
- Microglial cells
- Ependymal cells
- Oligodendrocytes
Types of neuroglia (glial cells) in the PNS (2)
- Satellite cells
2. Schwann cells
Astrocytes
Most abundant and versatile of the neuroglia
Star shaped, with projections connecting to and wrapping around neurons, synaptic nerve endings, and surrounding blood capillaries. Found in the CNS.
Major functions of the astrocytes (4)
- Provide a nutrient supply for neuron cells
- Makes the sure the neuron is growing in the correct direction
- Allows migration of young neurons
- “Clean up” outside neuron cells
What do astrocytes clean up outside of neuron cells?
Some substances could interfere with the function of the neurons if they’re freely floating around, such as leaked K+ ions, neurotransmitter
Microglial cells
Have long and thin processes that touch neurons, found in the CNS.
Microglial cells functions (2)
- Contact nearby neuron cells to monitor health - microglial cells pick up on neurons not doing what it’s supposed to do
- Phagocytize injured neurons
Why must microglial cells phagocytize injured neurons?
Microglial cells migrate toward injured neurons, where they transform into a macrophage and phagocytize the neuron (these neurons can’t send messages correctly, so they must be cleaned up).
Importance- the immune system has very limited access to the central nervous system
Ependymal cells
Function- lines central cavities of the central nervous system to circulate cerebrospinal fluid (CSF) within cavities. Most cells have cilia (to move and circulate CSF). Found in the CNS.
Oligodendrocytes
Associated with thicker nerve fibers in the CNS, extensions of the cells wrap around each fiber to produce a myelin sheath
Oligodendrocytes function
Create an insulating covering for individual neurons of the CNS
Importance- allows for fast and efficient transmission of electrical impulses
Satellite cells
Support and protect neuron cells in the PNS-cleanup duty, helps neurons get oxygen and nutrients.
Functionally similar to astrocytes, found in the PNS.
Schwann cells
Surround nerve fibers of PNS to form myelin sheaths, functionally similar to oligodendrocytes
Other than transmitting electrical impulses, what 3 characteristics do neurons have?
- Longevity- neurons last a lifetime. The nervous system will not be replaced over time, in contrast to other organ systems
- Amitotic- neurons do not reproduce
- Metabolism- neurons are very metabolically active. A portion of oxygen and nutrients dedicated to the nervous system
What 2 general structures do neurons have?
- Cell body
2. Processes
Cell body of neurons
Portion of cell containing the nucleus. Most are found in the CNS, protected by bone
Cell body function
Function- plasma membrane can receive information from surrounding neurons
Nuclei
Name for clusters of cell bodies in the CNS, however, ganglia is typically used as an umbrella term for all cell bodies.
Ganglia
Name for clusters of cell bodies in the PNS, but is typically used as an umbrella term for all cell bodies
Processes of neurons
Arm like extensions from the cell body of all neurons. There are 2 types.
Types of processes of neurons (2)
- Axons
2. Dendrites
Dendrites
Main receptive region of the neuron. A single neuron can have dozens of dendrites
Dendrites function
Function- provide increased surface area for incoming signals to be received, convey incoming messages toward the cell body. You want neurons to be highly sensitive to messages.
Axon
Single nerve fiber coming from a cell body. The axon is the conducting region of the neuron. Axons branch at the end to form terminal branches and form axon terminals.
Axon function
Function- generates and transmits nerve impulses away from the cell body
Tracts
Bundles of axons in the CNS- axon bundles save space. However, nerve is typically used as an umbrella term
Nerves
Bundles of axons in the PNS- axon bundles save space. However, nerve is typically used as an umbrella term for the CNS as well.
Axon terminals
Axons branch at the end to form terminal branches and form axon terminals.
The axon terminal is the portion of the neuron that releases the neurotransmitter, which will be received by the dendrites
Axon terminal function
Function- neurotransmitter released at the axon terminal to pass along the impulse to the next neuron
Myelin sheath function (2)
- Protects and electrically insulates long and/or large nerve fibers
- Increases speed at which these impulses are transmitted
Myelin sheath
Fatty covering, usually associated with specific types of fibers, like very long axons. Not usually found with short or thin fibers. Not all axons are myelinated.
Myelin sheath gaps
There are multiple Schwann cells on the axon in the PNS, but do not make contact with one another
How is myelination in the PNS accomplished?
Accomplished by Schwann cells, which wrap themselves around the axon multiple times to create layers of insulation
How is myelination in the CNS accomplished?
Accomplished by oligodendrocytes- a single oligodendrocyte can cover 60+ axons with branching processes. The oligodendrocyte processes wrap around the axon in layers, covering a much larger portion than a schwann cell.
A single oligodendrocyte has multiple processes and can therefore insulate multiple neurons
How are neurons grouped?
According to the direction in which nerve impulses travel relative to the central nervous system. Afferent or efferent
Afferent neurons
Sensory neurons- afferent neurons transmit signals from the body to the CNS.
Receptive endings can function as actual sensory structures, or they are associated with larger sensory receptors (other cell types).
A larger sensory receptor can receive more information and send it to the brain.
Where are the cell bodies of afferent neurons found?
Cell bodies are found outside the CNS
Efferent neurons
Motor neurons- efferent neurons transmit motor responses from the CNS to the body.
The cell bodies found inside the CNS.
Impulses travel to effector organs (muscles and glands).
Interneuron
Lie between sensory and motor neurons. Most neurons in the body are interneurons.
Mostly confined only to the CNS, make up 99% of all neurons in the body
Interneuron function
Function- pass signals through CNS pathways where integration and interpretation occurs
What is the resting membrane potential value?
-70 mV
Why do cells have a resting membrane potential?
So the inside of the cell is more negatively charged than the outside. All cells have a resting membrane potential, but neurons can change theirs faster than other cells.
Resting membrane potential importance in neurons
Neurons are able to change their resting membrane potential faster than other cell types- neuron communication occurs when the membrane potential changes. Without this quality- the nervous system loses its function. The CNS would not know what was going on. There must be a membrane potential and it must be able to change quickly.
Voltage
The measure of the potential energy by separate electrical charges (measured in V or mV). The greater the difference in charge between two points (or charges), the higher the voltage.
What creates voltage in the human body?
In the human body, difference in charge on either side of the cell’s plasma membrane creates voltage (also called a potential). Each side of the membrane is considered 2 points.
Current
Flow of electrical charge from one point to another, can be used to do work
What creates current in the human body?
In the human body, currents reflect movement of ions across a membrane along the axon
Resistance
Hindrance of charge flow from substances through which charge must travel
What creates resistance in the human body?
In the human body, plasma membranes provide resistance. Sodium is stopped from entering the cell entirely.
Insulator
A substance with high resistance (the myelin sheath is an example).
Conductor
A substance with low resistance