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Dermatology - Chapters > Chapter 10 - Vesicles & Bullae > Flashcards

Chapter 10 - Vesicles & Bullae Flashcards

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1
Q

Solid and palpable lesions are ________ lesions.

A

primary

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2
Q

what are the 4 types of solid and palpable lesions?

A

papule, nodule, plaque, cyst, wheal

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3
Q

Fluid filled lesions are _____ lesions.

A

primary

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4
Q

what are the 3 types of fluid filled lesions?

A

vesicle, bulla, pustule

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5
Q

open lesions are _____ lesions.

A

primary

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6
Q

what are the 3 types of open lesions?

A

erosion, ulcer, fissure

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7
Q

Atrophy, Scar, & telangiectasia are _____ lesions.

A

primary

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8
Q

What occur as a result of a change in the primary lesions?

A

secondary lesions

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9
Q

What are the 4 secondary lesions?

A

scale, crust, lichenification, verrucous

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10
Q

A primary fluid filled lesion greater than 1 cm?

A

Bullae

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11
Q

an intraepidermal (subcorneal) bacterial infection of the skin caused by certain strains of Staphlcoccus aureus.

A

Bullous impetigo

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12
Q

a contageious bacterial skin infection forming pustules and yellow,, crusty sores

A

impetigo

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13
Q

Where is Bullous impetigo most frequently found?

A

preschool age children

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14
Q

What are the predisposing factors of impetigo?

A

crowding, poor hygiene, chronic dermatitis, and neglected injury of the skin

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15
Q

When performing a physical examination of bollous impetigo (not ruptured yet), what would you expect to see?

A

fragile, cear or cloudy bullae. (blister containing fluid)

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16
Q

What would you expect to see if the bullae was ruptured?

A

a thin varnish-like crust. A delicate, collarette-like remnant of the blister roof is often present at the rim of the crust.

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17
Q

A patient has self infected (autoinoculation) herself with bollous impetigo. What would you expect to see during her physical examination?

A

secondary (satellite) lesions

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18
Q

What part of the body are most often affected by bollous impetigo?

A

face, neck, and extremities

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19
Q

t/f Patients diagnosed with bollous impetigo may have regional adenopathy and systemic symptoms.

A

false. regional adenopathy may be present as a symptom…. but systemic symptoms will NOT occur.

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20
Q

You suspect your patient has bullous impetigo. You must perform a differential diagnosis to be sure. What three other diseases are similar?

A
  1. Contact Dermatitis
  2. Herpes simplex virus HSV
  3. superficial fungal infections
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21
Q

A patient presenting with chronic, apparently impetignized, plaques that have not responded appropriate to antibiotics would be suspected to have _________.

A

pemphigus vulgaris

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22
Q

What disease is primarily found in infants and is characterized by sudden onset of fever, skin tenderness, erythema, followed by formation of large, flaccid bullae and shedding of large sheets of skin.

A

Staphylococcal scalded skin syndrome

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23
Q

What is the difference in Bullae of staphylococcal scalded skin syndrome and bollous impetigo?

A

s. auras can be recovered in bollous impetigo but in staphylococcal scalded skin syndrome the bullae are sterile.

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24
Q

What is the usual source of infection in staphylococcal scalded skin syndrome?

A

conjunctiva, nose, or pharynx; or in a newborn an infected umbilical stump

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25
Q

A PA usually does not perform a biopsy on patients presenting with bullous impetigo. Why?

A

gram staining of the clear or cloudy fluid from a bulla reveals gram positive cocci. S. aureus grows out in more than 95% of the cultures.

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26
Q

definition: detachment of the horny layer by an epidermolytic toxin produced by staphylococcus aureus causes _________. *be specific

A

subcorneal blister

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27
Q

How long does it take impetigo to heal spontaneously without treatment? how long with treatment?

A

3-6 weeks w/out treatment

w/ antibiotic heal w/in 1 week

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28
Q

In _______, the toxin is produced at the site of the lesion causing the blister; but in _______ the toxin is produced remotely (no physical contact) and then carried hematogenously to the skin.

A
  1. bullous impetigo

2. staphlococcal scalded skin syndrome

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29
Q

What disease is caused by infection with HSV?

A

Herpes simplex disease

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30
Q

Which HSV type causes oral infection? which causes genital infection?

A 
HSV-1 = oral
HSV-2 = genital
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31
Q

The incidence of which type of HSV is higher?`

A

HSV-1 at 50% ; HSV-2 is at 20%

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32
Q

Primary infection with HSV-1 usually occurs in children in whom it is subclinical in 90%. The remaining 10% of infected children have what?

A

acute gingivostomatis - (sore mouth)

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33
Q

HSV-2 primary infections usually occurs after sexual contact in post pubertal individuals, and it produces ______ or _____.

A

acute vulvovaginitis or progenitalis

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34
Q

T/F Primary infection with HSV is frequently accompanied by systemic symptoms.

A

true. - fever, malaise, myalgia, headache, & regional adenopathy.

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35
Q

Herpes labials would most likely be caused from _______.

A

HSV-1

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36
Q

In which of the types of HSV is the risk of recurrence lower?

A

HSV-1 at 14% ; HSV-2 is at 60%

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37
Q

What are two distinctions of Herpes would cause a PA to almost instantaneously know to it add to their differential diagnosis if these two distinctions were presented in a patient?

A

if a vesicular eruption is

  1. recurrent in same location
  2. preceded by a prodrome
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38
Q

Recurrent attacks of Herpes are preceded by what? (prodrome)

A

itching or burning

**also it will occur in the same location as before

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39
Q

indurated erythema followed by grouped vesicles on an erythematous base is typical of _______. The vesicles quickly then becomes ______, which rupture, weep, and crust.

A

herpes infections (HSV infections) ; become pustules

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40
Q

If the skin infected by HSV becomes necrotic, what will happen?

A

the affected skin becomes a punched out ulcer.

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41
Q

________ is a type of herpes that affects the fingers?

A

Herpetic whitlow

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42
Q

What traumatic herpes simplex has been reported among wrestlers?

A

Herpes gladiatorum

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43
Q

Which herpes is a generalized cutaneous infection with HSV in individuals with predisposing skin diseases such as Atopic Dermatitis.

A

Eczema herpeticum - usually accompanied by severe toxic symptoms that can be fatal

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44
Q

The occurrence of grouped vesicles on an erythematous base is characteristic of HSV infection. It can be confirmed with ______.

A

Tzanck smear = reveals multi-nucleated giant cells

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45
Q

What do you stain with using a Tzanck smear?

A

Giemsa, Wright, or toluidine blue

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46
Q

What can prevent the transmission of HSV-2?

A

condom

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47
Q

Can treatment prevent recurrent infection of herpes?

A

no

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48
Q

The incubation period after contact with HSV is how long?

A

1 week

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49
Q

The clinical course of primary herpes is how long

A

3 weeks

50
Q

A prodrome of 1-2 days is followed by a vesiculopustular eruption for ______ with primary herpes.

A

10 days

51
Q

T/F A patient diagnosed with herpes, who has had varying periods of latency, should not be worrisome of overt eruptions.

A

true.

52
Q

During a period of latency where does the herpes virus remain?

A

dorsal root ganglion corresponding to the site of infection

53
Q

What could initiate a recurrence of herpes?

A

fever, UV light, physical trauma, menstruation, emotional stress

54
Q

What is very common and instrumental in transmitting HSV to others?

A

asymptomatic, subclinical shedding of the HSV

55
Q

Babies born with HSV are termed to have ______.

A

Neonatal herpes

56
Q

Women who have evidence of active HSV infection at delivery should have what?

A

cesarean section

57
Q

What are the 3 complications of neonatal HSV infection discussed in the text?

A
  1. cultures to screen women immediately before delivery do not predict infection for the fetus
  2. more than 70% of mothers of babies with neonatal HSV have no history of genital HSV infection
  3. symptomatic disease may not occur for as long as one month after delivery
58
Q

2/3 of affected infants have ________ of HSV infection?

A

mucocutaneous manifestations of HSV infection

59
Q

A relatively uncommon complication of HSV infection is _______, its serum is composed of antibody and HSV antigen.

A

erythema multiform may occur after HSV infection

60
Q

What is caused by the recrudescence of latent varicella costar virus in persons who have had varicella? It occurs in a dermatomal distribution.

A

Herpes zoster

61
Q

Vesicular dermatomal eruption is distinctive of?

A

Herpes zoster

62
Q

Who is most at risk for herpes zoster?

A

patients over 50 years of age & have cancer or AIDS

63
Q

8-25% of patients with ________ develop herpes zoster.

A

Hodgkin’s disease

64
Q

Is there a low or high frequency of second attack of herpes zoster?

A

low- 5%

65
Q

Does herpes zoster present with a prodrome?

A

yes - radicular paid and itching. The prodrome can mimic migraine, pleurisy, myocardial infection, or appendicitis.

66
Q

In herpes zoster, the eruption is characterized by groups of vesicles on an erythematous base situated ________ along the distribution of _________.

A

unilaterally ; cranial or spinal nerve

**rarely bilaterally ; frequently involves dermatomes

67
Q

The dermatomal distribution of herpes zoster is diagnostic. However, ______ may also occur in a dermatomal fashion.

A

herpes simplex

68
Q

T/F You must always do a laboratory test to confirm herps zoster.

A

false! almost never have to

69
Q

T/F Herpes zoster is not am erker for occult malignant disease. It may be the presenting sign of HIV infection.

A

true.

70
Q

In herpes zoster, the succession of lesions begins with ____ , which develops into _____.

A

begins with macules and develops into vesicles

71
Q

What are two changes that may occur in herpes zoster that may result in scarring?

A
  1. hemorrhagic bullae

2. gangrenous changes

72
Q

Post-herpetic neuralgia is uncommon in patients less than _______ years old.

A

40 yrs old

73
Q

Other than old age, what is the other risk factor to developing post-herpetic neuralgia?

A

female, with a prodrome, and have more severe acute pain and eruption

74
Q

80T of patients with post-herpetic neuralgia become __________ within 12 months.

A

asymptomatic

75
Q

When herpes zoster involves the tip of the nose, what should a PA suspect is involved?

A

the eye. Herpes opthalmicus should be suspected because the nasociliary branch of the opthalmic division innervates the eye and the tip of the nose.

76
Q

T/F Bell’s palsy and full-thickness skin necrosis are two occasional complications of herpes zoster.

A

true

77
Q

T/F Viremia (presence of virus in the blood stream) frequently occurs in herpes zoster resulting in disseminated lesions.

A

true

78
Q

What is characterized by successive crops of rapidly progressive lesions over an 8-12 hour period with generalized vesicular eruptions; lesions are present in all stages?

A

Varicella (chickenpox)

79
Q

90% of Varicella cases occur before the age of _____.

A

10

80
Q

The incidence of varicella peaks sharply in which months?

A

March, April, & May

81
Q

The lesions begin as _____ and develop quickly into ____, ____, and _____ in varicella zoster.

A

macules; papules, vesicles, and pustules

82
Q

How do you distinguish small pox from chickenpox?

A

The presence of lesions in all stages in varicella is different from small pox in that small pox the lesions are in the same stage of development.

83
Q

T/F Disseminated herpes simplex, coxackievirus, and echovirus, as well as rickettsialpox could all be in a PA’s differential diagnosis when a patient presents with suspected varicella zoster.

A

true - all of these can present with vesicular eruptions similar to varicella zoster

84
Q

Chickenpox has all types of lesions. Name them.

A
  1. macules
  2. papules
  3. vesicles
  4. pustules
  5. crusts
85
Q

Culture of the varicella zoster virus is difficult; therefore what test is preferred?

A

vesicle smears by immunofluorescent staining is the preferred test.

86
Q

T/F The treatment of chickpox is largely symptomatic.

A

true

87
Q

What should be avoided in children for treatment for chickenpox? Why?

A

Asprin, because of its association with Reye syndrome

88
Q

Varicella vaccine that is safe and effective in health children and adults in preventing chickenpox

A

Varivax

89
Q

Passive immunization that is used in high risk patients. It contains plasma containing high titers of varicella zoster antibody and is effective in prevention in immunodeficient patients if administered shortly after exposure.

A

VZIG - varicella zoster immune globulin

90
Q

T/F Patients with leukemia or lymphoma, congenital or acquired immune deficiency, pt’s receiving immunosuprressive medication, and newborns of mothers who have varicella are candidates for treatment with VZIG.

A

true.

91
Q

T/F VZIG is not administered to patients with active disease.

A

true

92
Q

Where does varicella primary infection begin?

A

nasopharynx

93
Q

a metabolic disorder characterized by defective heme synthesis and excessive porphyrin production

A

Porphyria cutanea tarda

94
Q

a group of genetic disorders with mutations that produce structural defects in the epidermis or dermis

A

Epidermolysis bullosa

95
Q

an autoimmune disorder characterized by large and tense blisters that occur on normal or erythematous/urticarial appearing skin

A

Bullous pemphigoid

96
Q

where would u find bullous pemphigoid

A

flexor surfaces, groin, axillae

97
Q

where is the bister location in bullous pemphigoid

A

subepidermal

98
Q

How do the bullous pemphigoid and pemphigus vulgarism differ in regard to the bullae?

A

the bullae of bullous pemphigoind do not extend laterally like the bullae of vulgarism

99
Q

T/F Bullous Pemphigoid heals with scaring.

A

false. heals without scaring

100
Q

What immunoglobulin is found in bullous pemphigoid?

A

IgG

101
Q

chronic, intensely pruritic vesicular disease characterized by grouped papules, vesicles, and urticarial plaques, which are distributed symmetrically on the elbows, knees, buttocks, low back, and shoulders

A

Dermatitis Herpetiformis

102
Q

A patient presents with scratching excoriations, rather than vesicles, could Dermatitis Herpetiformis still be in a PA’s differential diagnosis?

A

YES. The vesicles are often not intact, secondary to scratching as a result of intense pruritus of Dermatitis Herpetiformis disease

103
Q

What immunoglobulin will the PA see when performing an indirect immunofluorescence test on a patient presenting with Dermatitis Herpetiformis?

A

IgA

104
Q

T/F One treatment with dapsone or sulfapyridine will cure a patient of Dermatitis Herpetiformis.

A

false- treatment with that will cause rapid clearing; but the disease recurs promptly when therapy is stopped

105
Q

75%of patients with Dermatitis Herpetiformis have associated what?

A

gluten - sensitive enteropathy (usually asymptomatic)

106
Q

What do you advise of your patient who has associated gluten - sensitive enteropathy due to Dermatitis Herpetiformis?

A

advise a strict gluten free diet to cause
1. remission
or
2. a significant reduction of the medication done

107
Q

What group of disorders is characterized by mutations in genes that encode for the structural proteins of the epidermis and dermis? This results in epidermal, junctional, and sub epidermal blisters produced by minor friction or trauma.

A

Epidermolysis bullosa

108
Q

What are the two types of Epidermolysis bullosa?

A

simplex and recessive dystrophic

109
Q

which type of epidermolysis bullosa has blistering limited to the hands and feet? and is caused by dominant keratin 5&14 gene mutations?

A

Epidermolysis bullosa simplex

110
Q

which type of epidermolysis bullosa results from mutations in the gene encoding type VII collagen, COL7A1. The severe form is characterized by mitten like deformity of the hands and feet, contractors, blistering and scarring of the mouth and eyes, esophageal strictures, growth retardation, anemia, and nutritional deficiency?

A

Recessive dystrophic epidermolysis bullosa

111
Q

What would you advise for treatment of a patient with epidermolysis bullosa?

A 
the treatment is symptomatic
protect from trauma
good wound care
treatment of infections
and nutritional supplements
112
Q

autoimmune disease characterized by blistering of the skin and mucous membranes. bullae are flaccid and superficial, RUPTURE EASY leaving large denuded, bleeding, weeping, and CRUSTED EROSIONS. Pressure applied LATERALLY to the bulla result in extension (POSITIVE NIKOLSKY’S SIGN).

A

Pemphigus Vulgaris

113
Q

what is frequently the presenting site and almost always involved in Pemphigus vulgaris

A

oral mucosa (erosions in the mouth)

114
Q

The bulla of pemphigus vulgarism occur ______ in relation to the epidermis? *which is different from bullous pemphigoid

A

intraepidermally

**whereas bullous pemphigoid occurs subepidermally and does extend laterally!

115
Q

before the introduction of systemic steroids, pemphigus vulgarism was associated with an extremely high mortality rate. But now that we have systemic steroids, death now occurs more frequently with _______ than from complications from the disease.

A

steroid-induced complications

116
Q

T/F If untreated, pemphigus vulgarism will cure itself within 3 weeks.

A

false!!! - untreated pemphigus vulgaris has a high mortality rate!!!!!

117
Q

a group of disorders characterized by abnormalities in the heme biosynthetic pathway resulting in abnormal porphyrin metabolism and excessive accumulation of various porphyrins.

A

porphyria cutanea tarda

118
Q

subepidermal blisters on the hands and excessive uroporphyrin excretion in the urinel; bullae, vesicles, erosions, crusts, milia, and milk scarrin occur on SUN EXPOSED SKIN!!

A

Porphyria cutanea tarda

119
Q

What can you test to diagnose porphyria cutanea tarda?

A

urinary levels of uroporphyrins and coproporphyrins are markedly raised with a ration of 3:1. liver function test results and serum iron levels are usually increased.

120
Q

what color is urine of a patient diagnosed with porphyria cutanea tarda using woods light?

A

fluoresces orange-red

**but without wood light looks dark brown

121
Q

T/F Variegate porphyria, hereditary coproporphyria, and porphyria cutanea tarda have identical skin findings.

A

true!

  • so do urinary test to eliminate variegate porphyria
  • do serum or fecal porphyrin measurement to diagnose hereditary coproporphyria

Dermatology - Chapters (18 decks)

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