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Behavioral > Chapter 10 ( Psychopharmacology ) > Flashcards

Chapter 10 ( Psychopharmacology ) Flashcards

1
Q

Side effects of antihistamincs ?

A

Sedation

Weight gain

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2
Q

Side effects of anticholinergics ?

A

Dry mouth
Blurry vision
Constipation
Confusion

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3
Q

Mechanism of action of antipsychotic drugs ?

A

Dopamine blockade at postsynaptic receptors

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4
Q

Side effects of antipsychotic drugs ? Peak ? Ttt ?

A

1- Dystonic reaction - hours to days - ttt: anticholinergics
2- Rigidity - 3 weeks - ttt: lower dose or anticholinergics
3- Tremors - 6 weeks - ttt: lower dose or anticholinergics
4- Akathisia - 10 weeks - ttt: B-blockers , benzodiazepines , lower dose or switch to atypical antipsychotics
5- Tardive dyskinesia - >3-6 months - ttt: switch to atypical antipsychotics
6- Neuroleptic malignant syndrome - anytime - ttt: dantrolene or bromocriptine

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5
Q

Typical antipsychotics?

A 
Haloperidol 
Fluphenazine 
Chlorpromazine
Mesoridazine 
Thioridazine
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6
Q

Thioridazine has an increased risk for ?

A

Retinitis pigmentosa

Retrograde ejaculation

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7
Q

Atypical antipsychotics ?

A

ZOP CLARQ :

Ziprasidone 
Olanzapine 
Paliperidone 
Clozapine 
Lurasidone 
Aripiprazole 
Risperidone 
Quetiapine
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8
Q

Clozapine has increased risk for ?

A

Agranulocytosis
Seizures
Drooling

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9
Q

Atypical antipsychotics that is partial dopamine agonist at low doses ?

A

Aripiprazole

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10
Q

Tricyclic antidepressants mechanism of action ?

A

Blocks :
Reuptake of serotonin and norepinephrine
Alpha 1 receptors
Muscarinic receptors

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11
Q

TCAs ?

A 
DANCI :
Desipramine 
Amitriptyline 
Nortriptyline 
Clomipramine 
Imipramine
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12
Q

The ttt pf choice for major depressive disorders with atypical features ?

A

Monoamine oxidase inhibitors

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13
Q

Function of monoamine oxidase ?

A

Metabolizes :
Serotonin
Epinephrine
Norepinephrine

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14
Q

MAOIs ?

A

TIP :

Tranylcypromine
Isocarboxazide
Phenelzine

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15
Q

Signs of hypertensive crisis ?

A 
Occipital headache 
Stiff neck 
Nausea vomiting 
Chest pain 
Dilated pupils
Nosebleed
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16
Q

Foods containing Tyramine that causes hypertensive crisis with MAOIs ?

A 
Aged cheese
Dried fish 
Sauerkraut 
Sausage 
Chocolate 
Avocados 
Red wine
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17
Q

SSRIs ?

A

F SPaCE F :

Fluoxetine 
Sertraline 
Paroxetine 
Citalopram 
Escitalipram 
Fluvoxamine
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18
Q

Serotonin syndrome causes ? Symptoms ? Ttt ?

A

High doses
MAOIs/SSRIs combo
MAOIs/synthetic narcotics combo

General restlessness , insomnia
Nausea , diarrhea , cramps
Delirium
Myoclonus

Ttt:
Removal the causative agent
Stopping SSRIs
Cyproheptadine

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19
Q

Serotonin norepinephrine reuptake inhibitors ?

A

Venlafaxine
Desvenlafaxine
Duloxetine

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20
Q

Mechanism of action of Trazodone ? Side effects ?

A

Serotonin receptor antagonist and alpha 1 blocker

Priapism and sedation

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21
Q

Mirtazapine mechanism of action ?

A

Stimulates norepinephrine and serotonin release

Blocks 5-HT2 and 5-HT3 receptors

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22
Q

Bupropion mechanism ? Side effects ?

A

Relatively weak inhibitor of neuronal reuptake of norepinephrine and dopamine ( dose not inhibit reuptake of serotonin )

Increased risk of seizures

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23
Q

The drug of choice for bipolar disorders ?

A

Lithium

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24
Q

Ttt of choice for lithium > 2,5 meq/L ?

A

Dialysis

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25
Q

Side effects of lithium ?

A 
Tremors 
Anorexia , git disturbances 
Polyuria , polydipsia , edema 
Acne 
Hypothyroidism 
Nephrotoxicity 
Teratogenicity ( Ebstein’s anomaly of the tricuspid valve ) 
DI
Ataxia , seizures, confusion ( if toxic )
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26
Q

Mechanism of action of valproic acid ?

A

Augmentation of GABA in CNS

27
Q

Toxicity of valproic acid causes ?

A

Liver damage ( hepatotoxic )

28
Q

Carbamazepine mechanism ? Side effects ? Toxicity ?

A

Blocking Na channels in neurons with action potential , it alters central GABA receptors .

Rash
GI distress
Mild leucopenia , agranulocytosis , aplastic anemia

Hypotension , tachycardia , respiratory depression , coma

29
Q

Lamotrigine is associaed with ?

A

Steven Johnson syndrome

30
Q

Benzodiazepines mechanism ? Side effects ?

A

Depression of the CNS at the limbic system , RAS and cortex by binding to GABA-Chloride receptors facilitating the action of GABA

Sedation 
Insomnia 
Addiction 
Falls 
Confusion 
Disinhibition
31
Q

Amittriptyline uses in addition to depression ?

A

Depression with insomnia

Chronic pain

32
Q

Clomipramine uses in addition to depression ?

A

Obsessive compulsive disorder

33
Q

Doxepin uses in addition to depression ?

A

Peptic ulcer

Pruritis

34
Q

Imipramine uses in addition to depression ?

A

Panic disorder with agoraphobia
Enuresis
Eating disorders
The

35
Q

Maprotiline uses in addition to depression ?

A

Anxiety with depressive features

36
Q

Nortriptyline uses in addition to depression ?

A

Depression in elderly
Pruritis
Patients with cardiac diseases

37
Q

Protriptyline uses in addition to depression ?

A

ADHD

Narcolepsy

38
Q

Citalopram uses in addition to depression ?

A

OCD

Panic disorder

39
Q

Escitalopram uses in addition to depression ?

A

Chronic pain
Paraphilia
Generalized anxiety disorder

40
Q

Fluoxetine uses in addition to depression ?

A

Social anxiety disorder
Premenstrual dysphoria
PTSD

41
Q

Flucoxamine uses in addition to depression ?

A

Bulimia nervosa

42
Q

Paroxetine uses in addition to depression ?

A

Premature ejaculation
Body dysmorphic disorder
Hot flashes

43
Q

Vortioxetine indicated only for ?

A

Major depressive disorder

44
Q

Duloxetine uses in addition to depression ?

A

Generalized anxiety disorder

Social anxiety disorder

45
Q

Venlafaxine and desvenlafaxine uses in addition to depression ?

A

Panic disorder

Chronic pain

46
Q

Levomilnacipran is indicated only in ?

A

Major depressive disorder

47
Q

Isocarboxazid uses in addition to depression ?

A

Geriatric depression

48
Q

Tranylcypromine uses in addition to depression ?

A

Atypical depression

49
Q

Phenelzine uses in addition to depression ?

A

Pain disorders
Eating disorders
Panic disorders

50
Q

Selegiline uses in addition to depression ?

A

Social anxiety disorder

51
Q

Amoxapine uses in addition to depression ?

A

Depression with psychotic features

52
Q

Bupropion uses in addition to depression ?

A 
Smoking cessation 
Major depressive disorder with seasonal pattern 
SSRI induced sexual dysfunction 
Adult ADHD
Obesity
53
Q

Mitrazapine uses in addition to depression ?

A

Insomnia

54
Q

Trazodone uses in addition to depression ?

A

Insomnia

55
Q

Vilazodone indicated only for ?

A

Major depressive disorder

56
Q

Clorazepate uses in addition to anxiety ?

A

Partial seizures

57
Q

Triazolam uses in addition to anxiety ?

A

Insomnia

58
Q

Alprazolam uses in addition to anxiety ?

A

Depression
Panic disorder
Social anxiety disorder

59
Q

Lorazepam uses in addition to anxiety ?

A

Psychotic agitation
Alcohol withdrawal
Acute control of seizures

60
Q

Temazepam uses in addition to anxiety ?

A

Insomnia

61
Q

Chlordiazepoxide uses in addition to anxiety ?

A

Alcohol withdrawal

62
Q

Clonazepam uses in addition to anxiety ?

A 
Seizures 
Mania 
Social anxiety disorder 
Panic disorder 
Obsessive compulsive disorder
63
Q

Diazepam uses in addition to anxiety ?

A

Muscle relaxation
Analgesia
Seizures
Alcohol withdrawal

64
Q

Flurazepam uses in addition to anxiety ?

A

Insomnia

Behavioral (11 decks)

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