Chapter 1: Biochem and the organization of cells Flashcards
Organism can be studied using the methods of chemistry and physics as all living things use:
- The same types of Biomolecules
- Energy
Biochemistry is a ___________________ in nature
Multidisciplinary
it combines biology and chemistry
Biochemistry
Uses results from many sciences to answer questions about the molecular nature of life processes.
Biochemistry
Simple molecules must have arisen from atoms:
Chemical Names
H2O -
CH4 -
CO2 -
NH3 -
N2 -
H2 -
Water
Methane
Carbon Dioxide
Ammonia
Nitrogen
Hydrogen gas
Study of compounds of carbon and hydrogen and their derivatives
Organic Chemistry
Biomolecules are part of the subject matter of organic chemistry because cellular apparatus of living organisms is made up of _________________ compounds.
Carbon
_____________ experiment in 1828
Ammonium Cyanate ——-> Urea
Friedrich Wöhler’s
Structure - Central carbon atom is bonded to a carboxyl group, an amino group, a hydrogen, and the R group
Amino acid
- Compounds made up of carbon, hydrogen, and oxygen
- General formula - (CH2O)n, where n is at least 3
- Simplest form - Monosaccharides, or sugars
Carbohydrates
the most common monosaccharide
Glucose
- Basic unit of the hereditary materials DNA and RNA
- Composed of a five-carbon sugar, a nitrogencontaining ring, and one or more phosphate groups
Nucleotides
Form the molecular currency of the cell
Adenosine Triphosphate
Poorly soluble in water because they are composed of
long chains of hydrocarbons
Give an example of a simple lipid:
Lipids
Palmitic Acid
vital importance in biochemistry
Esters and anhydrides of phosphoric acid
- Energy currency of the cell
- Also containes ester and anhydrides linkages involving phosphoric acid
Adenosines Triphospate (ATP)
BIG BANG THEORY: ORIGIN OF THE UNIVERSE
Primordial fireball started to expand with great force as a result of an explosion
- Temperature was approximately_______________?
15 X 10^9 K
BIG BANG THEORY: ORIGIN OF THE UNIVERSE
____________ were the only elements present in the earliest stages of the Universe**
H, He and Li
(Hydrogen, Helium, Lithium)
Biomolecules
Gases present in the atmosphere of the early Earth
NH3, H2S, CO, CO2, CH4, N2, H2, and H2O
( Ammonia, Hydrogen sulfide, Carbon monoxide, Carbon Dioxide, Methane, Nitrogen, Hydrogen Gas, Water)
BIOMOLECULES
Experiments have demonstrated that important
biomolecules, such as proteins and nucleic acids,
could have arisen under ____________ conditions
Abiotic (nonliving)
Living cells include very large molecules, such as
proteins, nucleic acids, polysaccharides, and lipids
Biomolecules
Small molecules that may bond to many
others to form a polymer
Monomers
Greek - Mono + meros
__________ + ______ = Monomers
Single + Part
Biomolecules
Amino Acids →
Proteins
Biomolecules
Nucleotides → __________
Nucleic Acids
Biomolecules
Monosaccharides → ___________
Polysaccharides
Biomolecules
Glycerol and 3 fatty acids → ___________
Lipids
Biomolecules
Macromolecules formed by the bonding of
smaller units
Polymers
Biomolecules
Macromolecules formed by the
polymerization of amino acids
Proteins
Biomolecules
Macromolecules formed by the
polymerization of nucleotides
Nucleic acids
Biomolecules
Class of proteins that display catalytics activity
Enzymes
Biomolecules
Ability to increase the rate of a chemical reaction.
Catalytic Activity
Catalytic effectiveness of a given enzyme depends on its ____ sequence
Amino acid sequence
Relationship between the nucleotide sequence in nucleic acids and the amino acid sequence in proteins
Genetic Code
Serves as the coding material
Deoxyribonucleic Acid (DNA)
Molecules to Cells
- It has the capability to catalyzes itw own processing.
- Considered to have been the original coding material and still serves this function in some viruses.
Ribonucleic Acid
Molecules to Cells
Appearance of a form of RNA capable of coding for its own replication was the pivotal point in the origin of life.
RNA World Theory
Original ____ both encoded and catalyzed its own
replication
RNA
____ became the primary genetic material, and ____ took on only an intermediary role in the** synthesis of proteins**
DNA
RNA
Molecules to Cells
________ that seperates cells from their environment is a key point in the development of living cells.
Formation of Membranes
Molecules to Cells
Development of catalysis and the development of a coding system came about separately.
- Combination of the two later in time produced life
Double-Origin Theory
- Microorganism that lack a distinct nucleus and membrane-enclosed organelles
- Include bacteria and cyanobacteria
Prokaryotes
- ## Organisms whose cells have a well-defined nucleus and membrane-enclosed organelles
Eukaryotes
Prokaryotes and Eukaryotes
Yeasts and Paramecium
Unicellular
Prokaryotes and Eukaryotes
Animals and Plants
Multicellular
Membrane-enclosed portion of a cell with a specific function
Organelles
Summary of Organelles and Their Functions
Location of main genome; site of most DNA and RNA synthesis
Nucleus
Summary of Organelles and Their Functions
Site of energy-yielding oxidation reactions; has its own DNA
Mitochondrion
Site of photosynthesis in green plants and algae; has its own DNA
Chloroplasts
Summary of Organelles and Their Functions
Continuous membrane throughout the cell; rough part studded with ribosomes (the site of protein synthesis)
Endoplasmic Reticulum
Summary of Organelles and Their Functions
Series of flatted membranes involved in secretion of proteins from cells and in reactions that link sugars to other celluilar components.
Golgi Apparatus
Summary of Organelles and Their Functions
Membrane-enclosed sacs containing hydrolytic enzymes
Lysosomes
Summary of Organelles and Their Functions
Sacs that contain enzymes involved in the metabolism of hydrogen peroxide
Peroxisomes
Summary of Organelles and Their Functions
Separates the cell contents from the outside world; contents include organelles (held in place by the cytoskeleton) and the cytosol
Cell Membrane
Summary of Organelles and Their Functions
Rigid exterior layer of plant cells
Cell Wall
Summary of Organelles and Their Functions
Membrane-enclosed sac (plant cells)
Central Vacuole
Classifying Living Organisms: Five-Kingdom System
- Takes into account the differences between prokaryotes and eukaryotes
- Provides classifications for ________ that are neither plants nor animals
eukaryotes
Classifying Living Organisms: Five-Kingdom System
Kingdoms:
- Monera
- Protista
- Fungi
- Plantae
- Animalia
Source of Energy in Life Processes
Ultimate source of energy for all life on Earth
Sun
Source of Energy in Life Processes
____________organisms use light energy to drive the energy-requiring synthesis of carbohydrates.
Photosynthetic
Source of Energy in Life Processes
organisms consume carbohydrates and use them as energy sources
Nonphotosynthetic
Study of transformations and transfer of energy
Thermodynamics
Change in energy depends only on the state of the molecules present at the start of the process and the state of those present at the end of the process
Thermodynamics
Energetics of a chemical reaction
If the change in free energy is ____________ (free energy decreases), the reaction is spontaneous
negative
Energetics of a chemical reaction
If the change is ________ (free energy increases), the reaction will not occur unless energy is supplied from an external source
positive
can take several forms and can be converted
from one form to another
Energy
Characteristic of a reaction or process that takes place without outside intervention
Spontaneous
- Diagnostic for the spontaneity of a reaction at constant temperature
- Indicated by the symbol G
Sign of the change in free energy, ∆G, indicates the
direction of the reaction
* ________ - Spontaneous exergonic
* Exergonic: Energy-releasing
* ________- Nonspontaneous endergonic
* **Endergonic: **Energy-absorbing
* _________- Equilibrium
∆G < 0
∆G > 0
∆G = 0
LAWS OF THERMODYNAMICS
First and the second laws can be related to the free energy by an equation
△G = △H −T△S
LAWS OF THERMODYNAMICS
changes in enthalpy
△H
Heat of a reaction at constant pressure
Enthalpy
the changes in entropy
△S
the changes in free energy
△G
the temperature
T