CHAPTER 1 Flashcards
HEMATOLOGYmdeals with the study of blood; includes analysis of the following:
Hemostasis
Concentration of formed elements
Morphology or structure of blood cells
Functions of the blood cells
Precursors
Death
Anemia, Leukemia
Hemocytometry
Concentration of formed elements
Branch of medicine which deals with the performance of diagnostic lab procedures, the results of which are correlated to clinical signs and symptoms of the patients
HEMATOLOGY
Any abnormal feature of blood cells
BLOOD DYSCRASIAS
Diminished oxygen-carrying capacity of the blood
ANEMIA
ANEMIA
Due to
Due to
Due to
reduction in the number of RBCs
reduction in the hemoglobin content
both factors
A disease of blood-forming organs, characterized by proliferation of neoplastic WBCs
LEUKEMIA
Loose connective tissue
BLOOD
A nutritive medium which circulates within an enclosed system
Loose connective tissue
Arteries, veins, capillaries, lymphatics
VASCULAR SYSTEM
: major blood production site of fetus
Yolk sac
Color:
Venous blood:
Arterial blood:
red
dark red
bright red (oxyhemoglobin)
more viscous than water
3x to 5x
Coagulates between (?) (average)
5 to 10 minutes
in circulation
Liquid state
pH
7.35 - 7.45 (Ave. 7.4)
Specific gravity:
(Serum: (?))
(RBC: (?))
1.048 - 1.066
1.026 ± 1.031
1.092 ± 1.095
Volume: (?)
(% of our body weight)
Males :
Females:
5 to 6 L
7-8
76 ml/kg body wt
68 ml/kg body w
Capillary blood:
Pale or bright red
Liquid portion
(?) of blood volume
(?) water
(?) - proteins, CHO, lipids, vitamins, hormones, enzymes
55%
91-92%
6-7%
Plasma Proteins:
a. Albumin
b. Globulin
e. Fibrinogen
- maintains normal osmotic pressure; most important
a. Albumin (4%)
- involved in the transport of bilirubin, lipids, and steroids
Alpha-globulin
- associated with transport of iron and copper
Beta-globulin
- antibodies
Gamma-globulin
- precursor of fibrin
e. Fibrinogen (0.3%)
- both are fluid portions of blood
SERUM VS PLASMA
From clotted blood
Serum
Has no clotting factors (used up in the clotting process)
Serum
From anticoagulated blood or unclotted blood
Plasma
Has clotting factors (eg. Fibrinogen)
Plasma
- 45% of whole blood
- Solid portion
a. RBC –
erythrocyte, erythroplastid, normocyte, akaryocyte, discocyte
Transport of respiratory gases
RBC
b. WBC –
leukocyte, leukoplastid
Granulocytes:
basophil, eosinophil, neutrophil
Agranulocytes:
lymphocyte, monocyte
c. Platelet –
thrombocyte, thromboplastid
Important to maintain a balance in hemostasis
Platelet
– dust particles in blood; small refractive colorless particles in the blood that are probably granules from blood cells or minute fat globules
Hemoconia
Gaseous portion
pCO2, Po2
Portion where exchange between O2 and CO2 for normal respiration occurs
Gaseous portion
FUNCTIONS OF BLOOD
- Transportation
- Regulation (sweating)
- Protection
gases to facilitate gas exchange (O2 and CO2)
Transportation
products of digestion to tissues where they will be metabolized or assimilated
Transportation
waste products of catabolism to the excretory organs
Transportation
hormones and other endocrine secretions that regulate cell functions
Transportation
– CO2, O2
Respiratory
– Macromolecules (CHO, lipids)
Nutritive
– Exhalation, Urination
Excretory
Hormonal
Regulation
Temperature – thermoregulation
Regulation
↑ BP, ↓ BT
↓ BP, ↑ BT
Regulation
protects against blood loss when vessels are damaged (hemostasis)
Clotting
is performed by the leukocytes that protect against many disease-causing agents
Immune