Chapter 1 Flashcards
Structures that make up the Central Nervous System
Brain
Spinal Cord
How many neurons does the brain have?
100 Billion
How many neurons does the spinal cord have?
100 Million
Number of cranial nerves
12
Number of spinal nerves
31 pairs
Specialized cells that monitor change in the internal and external enviroment
Sensory Receptors
Small masses of nervous tissue consisting of neuronal cell bodies that are located outside the brain and spinal cord
Ganglia
Extensive network of nerves that are located in the walls of the GI tract that help regulate the digestion system
Enteric Plexus
Name the tasks that the Nervous System carries out
- Smell
- Touch
- Temperature
- Speech
- Memory
- Body movement
- Operation of the internal organs
Three basic functions of the Nervous System
- Sensory Function
- Integrative Function
- Motor Function
Detect internal and external stimuli and carry information into brain and spinal cord via cranial and spinal nerves
Sensory function afferent
The ‘Information Processing’. Consist of Perception and Analyzing/Storing information to help lead to appropriate responses
Integrative Function
Once integration occurs the brain may elicit motor response to muscles or glands (effectors) via cranial and spinal nerves
Motor Function (Efferent)
Two cells that nervous tissue consists of
Neurons and Neuroglia
Provide most of the unique functions of the nervous system
Neurons
Function is to provide support, nourishment, and protection
Neuroglia
The parts of a Neuron
Cell Body
Dendrites
Axon
Axon Terminals
Highly branched structures that carry impulses to the cell body
Dendrites
Conducts away from the cell body toward another neuron, muscle, or gland
Axon
Contain synaptic vesicles that can release neurotransmitters
Axon Terminals
Structure Class:
Have several or many dendrites and one axon
Most common type in brain and spinal
Multipolar
Structure Class:
One Dendrite and one axon
Found in the retina of eye and inner ear
Bipolar
Structure Class:
Fused dendrite and axon
Sensory neurons of spinal nerves
Unipolar
Functional Classes of Neurons
Sensory
Motor
Interneurons
Convey impulses into CNS
Sensory
Convey impulses from brain or spinal cord out through the PNS to effectors (Muscles or Glands)
Motor
Located within the CNS
Transmit impulses between neurons, such as between sensory and motor neurons
Interneurons (association neurons)
Support, nourish, and protect neurons
Critical for homeostasis of interstitial fluid and neurons
Cells smaller but much more numerous than neurons
Make up half the volume of the CNS
Neuroglia
Functions of Neuroglia
- Do NOT generate or conduct nerve impulses
- Support, nourish and protect neurons
- In case of injury or disease, neuroglia can multiply to fill in space formerly occupied by neurons
Neuroglia that forms the blood brain barrier
Astrocytes
Neuroglia that produce myelin in CNS
Oligodendrocytes
Neuroglia that protects CNS cells from disease
Microglia
Neuroglia that forms CSF in ventricles
Ependymal cells
Neuroglia that produce myelin around PNS neurons
Schwann cells
Neuroglia that produces myelin around PNS neurons
Schwann cells
Neuroglia that supports neurons in the PNS ganglia
Satellite cells
Insulates the axon and speeds up the nerve impulse
Myelin
Gaps in myelin along the axon
Nodes of Ranvier
Diseases that destroy myelin sheaths
- Multiple Sclerosis
- Tay-Sachs
What increases from birth to maturity?
Myelin
Cluster of cell bodies in PNS
Ganglion
Cluster of cell bodies in CNS
Nucleus
Bundle of axons in PNS
Nerve
Bundle of axons in CNS
Tract
White matter mostly consists of what?
Myelinated axons
What makes up Gray Matter?
- Cell Bodies
- Dendrites
- Unmyelinated Axons
- Axon Terminals
- Neuroglia
Locations of gray and white matter in the Spinal Cord
White matter surrounds centrally located gray matter “H” or “Butterfly”
Location of gray and white matter in the Brain
Gray matter in a thin cortex surrounds white matter (tracts)
When can an axon and dendrite in the PNS be repaired?
Cell body is intact & Schwann cells are functional
Regeneration of CNS neurons
VERY limited even if the cell body is intact
Inhibited by neuroglia and by lack of fetal growth-stimulator cues
What allows communication between neurons?
Action potentials (nerve impulses)
What are the requirements for Action Potentials?
- Resting Membrane Potential
- Ion Channels
A charge difference across cell membrane (polarization)
Resting Membrane Potential
Allows ions to move by diffusion from high to low concentration
Ion Channels
What allows ions to open and close on command
Gate Channels
Triggers resting membrane to become more permeable to Na+
Causes enough Na+ to enter the cell to reach -55 mv (from -70 mv)
If threshold is reached, an action happens
Initial Event (STIMULUS)
Voltage gated Na+ channels open - More Na+ enters
Membrane rises and becomes positive (+30)
Depolarizing Phase
Voltage gated K+ channels open - as more K+ leave cell, membrane potential is returned to resting value (+30 to 0 back down to -70 mv)
Repolarizing Phase
What is it called when nerve impulses travel from where they arise (axon hillock), along the axon on the axon terminal?
Propagation
Unmyelinated axons, currents flow across adjacent portions of the plasma membrane
Continuous conduction
In myelinated axons, Nodes of Ranvier allow impulses to “leap” from a node to the next
Saltatory Conduction
Allows neurons to communicate with other neurons or effectors
Synapses
Synaptic transmission is triggered by what?
Action Potential (Nerve Impulse)
Components of Synapse
- Presynaptic neuron
- Synaptic cleft
- Postsynaptic neuron
Sending neuron, releases neurotransmitter
Presynaptic neuron
Space between neurons
Synaptic cleft
Receiving neuron, has receptors that bind to neurotransmitter
Postsynaptic neuron
Action potentials can only travel in one direction from dendrite to axon
One-way transmission
Action potential arrives at presynaptic neuron’s end bulk
Opens voltage Gated Ca2+ channels
Ca2+ flows in presynaptic cytosol
Increased Ca2+ concentration causes exocytosis of synaptic vesicles
Neurotransmitter (NT) released into cleft
NT diffuse across cleft and bind to receptors on the postsynaptic cell membrane
NT acts as chemical trigger, opening ion channels which changes the voltage across the postsynaptic cell membrane
Postsynaptic cell membrane may be depolarized or hyperpolarized, depending on which ions were admitted
If threshold reached (-55 mv) then postsynaptic AP results and nerve impulse is triggered
Synaptic Transmission
How is a NT removed from a cleft?
- Diffusion
- Destruction by enzymes
- Transport back into presynaptic cell (recycling)
Acetylcholine, Amino Acids, Modified Amino Acids, Neuropeptides, and Nitric Oxide
Neurotransmitters
Parasympathetic nervous system uses what neurotransmitter?
Acetylcholine (Ach)
Stimulatory Acetylcholine are found where?
Skeletal Muscles
Inhibitory Acetylcholine are found where?
Cardiac muscle
- Glutamate
- Aspartate
- Gamma Aminobutyric Acid (GABA)
Are examples of what?
Amino Acids
- Norepinephrine (NE)
- Dopamine (DA)
- Serotonin
Modified Amino Acids
What nervous system provides thoughts, emotions, and memories?
CNS
Cranial nerves and spinal nerves are a part of what nervous system?
PNS
ALL nervous tissue outside the central nervous system (Brain and Spinal Cord)
Peripheral Nervous System
Subdivisions of the PNS
- Somatic Nervous System (SNS)
- Autonomic Nervous System (ANS)
- Enteric Nervous System (ENS)
Sensory: Convey info from head, body wall, and limbs and from receptors for special senses (vision, hearing, taste, smell) to CNS
Motor: Conduct impulses from CNS to skeletal muscles (voluntary control)
Somatic Nervous System
Sensory: Convey information from receptors in visceral organs (stomach and lungs) to CNS
Motor: Conduct impulses from CNS to smooth muscles, cardiac muscles, and glands (involuntary control)
Autonomic Nervous System
“Fight or fight”
Sympathetic (ANS)
“Rest and Digest”
Parasympathetic (ANS)
Brain of the Gut
Enteric Nervous System
Sensory: Monitor chemical changes in GI tract, stretching of walls
Motor: Regulate contractions, acid secretion, endocrine cell secretions
Involuntary Control
Enteric Nervous System