Chap 80 Takayasu

Question 1

What is Takayasu’s?

Answer 1

immune arteritis causing inflammation of aorta, its major branches, and pulmonary arteries.

Question 2

What are proposed aetiologies of Takayasu?

Answer 2

genetic (HLA-Bw52)
immune mediated (cell and antibody)

Question 3

What is histology of TA?

Answer 3

panarteritis (3 layers) with skip area

excessive ground substance in intima

Question 4

What are clinical features of TA?

Answer 4

claudication (UE>LE)
diminished pulses
MSK symptoms
constitutional symptoms
H/A
CVI symptoms'
HTN common

Question 5

What are findings on duplex?

Answer 5

thickened wall

Question 6

Describe the1994 Tokyo international conference angiographic classification for TA?

Answer 6

Type I aortic arch branches alone
type II ascending, arch, branches
Type III ascending, arch branches and descending

Question 7

Describe the1994 Tokyo international conference angiographic classification for TA?

Answer 7

Type I aortic arch branches alone
type II ascending, arch, branches
Type III ascending, arch branches and descending
Type IV abdominal aorta and branches
Type V entire aorta

Question 8

What are features of active disease?

Answer 8

fever, myalgias
elevated ESR
vascular ischemia (claudication)
typical angio features

Question 9

What is medical treatment?

Answer 9

glucocorticoids first line treatment

methotrexate, cyclophosphamide, azathioprine

Question 10

What is invasive treatment strategies?

Answer 10

dont operate on active disease
endo poor results
bypass good patency