Chap 3 Part 1 Flashcards
What are the 2 main functions of Cartilage?
support and serves as a template for endochondral bone ossification
What are the 3 types of cartilage?
hyaline, elastic and fibrocartilage
Which type of cartilage is primarily collagen II fibers?
hyaline
Which type of cartilage is primarily elastic and collagen II?
elastic
Which type of cartilage is primarily collagen I and some collagen II?
fibrocartilage
What kind of cartilage is found in the the nasal cartilage?
hyaline
What kind of cartilage is found in the epiglottis?
elastic
What kind of cartilage is the pubic symphysis?
fibrocartilage
What are the 4 main components of the ground substance of hyaline cartilage matrix?
aggrecans, hyaluronic Acid, other proteoglycans, and chondronectin
What two things make up the matrix of hyaline cartilage?
ground substance and fibers (primarily Collagen II)
What are aggrecans?
large molecules composed of proteins and sulfated GAGs
What are the 3 types of cells associated with hyaline cartilage?
chondrogenic cells, chondroblasts, and chondrocytes
Which cells associated with hyaline cartilage appear very narrow, are derived from mesenchyme cells and sometimes osteoprogenitor cells, undergo mitosis and function as a source of chondroblasts?
chondrogenic cells
what do chondrogenic cells differentiate into?
chondroblasts or mature osteoprogenitors
where are chondrogenic cells located?
chondrogenic perichondrium
Which cells associated with hyaline cartilage differentiate into chondrocytes, produce the matrix, and have a lower nutrient requirement that allows them to be inactive for long periods of time?
chondroblasts
Which cells associated with hyaline cartilage are rounder and larger, located interior to the perichondrium, do not differentiate, and function to maintain the matrix/prevent calcification?
chondrocyte
which cell associated with hyaline cartilage probably does not undergo mitosis (but maybe)?
chondrocyte
T/F: chondrocytes live within a lacuna and have a very high nutrient requirement.
False; they do live in a lacuna but have a very low nutrient requirement; sometimes they exist in isogenic groups
Chondrocytes can sometimes secrete territorial matrix. How is territorial matrix different from regular matrix?
higher in GAGs and lower in fibers
Where is the perichondrium? exceptions?
peripheral to cartilage; epiphyseal growth plates and articular cartilage
What are the two parts of the perichondrium?
fibrous perichondrium and chondrogenic perichondrium
What is the primary cell type of the fibrous perichondrium? primary fiber type?
fibroblast; collagen I
T/F:fibrous perichondrium is avascular.
False; chondrogenic perichondrium is avascular
T/F: Chondrogenic perichondrium is located between fibrous perichondrium and mature cartilage.
True
What is the primary cell type of chondrogenic perichondrium? primary fiber type?
chondrogenic cells and chondroblasts; collagen II
What is perichondrium a source of and why is this important?
source of chondrogenic cells and chondroblasts which leads to more cells and matrix produced
T/F: all original cartilage develops from embryonic mesenchyme tissue.
True
What begins with a grouping of rounded mesenchymal cells that can be called a chondrogenic nodule located towards the center of the developing tissue?
Interstitial Cartilage Growth
Do chondroblasts divide within the chondrogenic nodule during interstitial cartilage growth?
yes
What secretes matrix during interstitial cartilage growth?
chondroblasts
What happens to secretion (during interstitial growth) after enough matrix concentrate or sets up?
secretion stops
During interstitial cartilage growth:
What do chondrocytes develop from? When they divide what do they create? What kind of new matrix will they secrete?
chondroblasts; isogenous groups; territorial
What is the stopping point of cartilage development?
chondrogenic perichondrium
Where does interstitial cartilage growth take place?
epiphyseal growth plates, and articular cartilage
