Chap 21. Zoonosis

Question 1

cause of plague

Gram +or -

Answer 1

Yersenia pestis

Question 2

Francisella tularensis

+or-

Answer 2

-,

Question 3

Opportunistic, Zoonatic gram -

Bird ticks, rabbits and bioterrorism

Answer 3

Francisella tularensis

Question 4

Diseases: 􀀂rabbit fever􀀃, 􀀂tick fever􀀃
• ulceroglandular and
oculoglandular tularemia
• pulmonary tularemia

Answer 4

Francisella tularensis

Question 5

Brucella neg or pos?

Answer 5

G-

Question 6

opportunistic zoonosis by B.melitensis (or bioterrorism

Answer 6

Brucella

Question 7

Undulant fever. Bangs Disease

Answer 7

Brucella. Brucellosis

Question 8

Systematic bacteremia starting from infected lymp nodes

Answer 8

Brucella

Question 9

Organisms penetrate mucus membrane and carreid to the heart and kidneys via blood and lyphatics.

They are resistant to phagositic killing

Answer 9

Brucella

Question 10

Haemophilus influenzae

Neg or Pos?

Answer 10

G-

Question 11

frequently part of oral flora (carrier rate up to 80%)

6 O-antigen serotypes: a – f: type b is most virulent

Answer 11

Haemophilus influenzae

Question 12

Haemophilus influenzae

Most virulent O-antigen?

Answer 12

type B

Question 13

Polyribitol phosphate (PRP)

Answer 13

Haemophilus influenzae

Capsule B.

Question 14

Conjugated vaccine against
............... polysaccharides
creates protective IgG,
preventing systemic infections
Vaccine does not protect against
other encapsulated strains and
unencapsulated strains

Answer 14

Conjugated vaccine against
capsule b polysaccharides
creates protective IgG,
preventing systemic infections
Vaccine does not protect against
other encapsulated strains and
unencapsulated strains

Question 15

Without vaccination: systemic diseases
(in children) by encapsulated strains:
• meningitis
• septicemia, cellulitis, epiglottitis

Answer 15

Haemophilus influenzae

Question 16

aerosol transmission
respiratory tract in
elderly
capsule B:

Answer 16

Haemophilus influenzae

Question 17

Legionella pneumophila

Neg or pos

Answer 17

G-

Question 18

facultatively intracellular (prevents endosome-lysosome fusion;
autophagosome-like uptake)
Lives and proliferates in the vacuoles of amoebas and
in the endoplasmic reticulum of macrophages

Answer 18

Legionella pneumophila

Question 19

Growth up to 46C

Relatively resistant to chlorine and other biocides

Answer 19

Legionella pneumophila

Question 20

Discovery: 1976 convention in Philadelphia 􀀂 infected roof A/C

Answer 20

Legionnaires􀀁 disease:

Legionella pneumophila

Question 21

Listeria monocytogenes

POS or NEG?

Answer 21

G+ mf

Question 22

acid-resistant
• cold-resistant (psychrotolerant)
(growth from 1ºC to 45ºC)
• salt-resistant
• motile
• food-borne pathogen
(processed meat like hot dogs,
dairy like Brie cheese; 4ºC stored)
• facultatively intracellular
(enterocytes, macrophages)

Answer 22

Listeria monocytogenes

Question 23

acid-activated hemolysin 􀀂 weak β-hemolysis)

Answer 23

listeriolysin O (

Question 24

pore-forming toxin (phagosome escape)

Answer 24

listeriolysin O

Question 25

………………… is rare (2500 cases/yr)
But exposure is common (10%
asymptomatic carriers)

Answer 25

Listeriosis is rare (2500 cases/yr)
But exposure is common (10%
asymptomatic carriers)

Question 26

Listeria crosses mucus membrane via M-cells

Answer 26

Mcells. Gets engolfed by macropages. Breaks them, then enters host cells via endocytosis. Spreads laterally to adjacent cells, propelled by actin filaments.

Question 27

In wild-type Listeria, where the bacteria
escape to the cytoplasm, the additional
lytic action by ………… is required
before the infection is eradicated.

Answer 27

In wild-type Listeria, where the bacteria
escape to the cytoplasm, the additional
lytic action by CD8+ CTL􀀁s is required
before the infection is eradicated.

Question 28

In mutant Listeria that lack lysteriolysin,
the oxidative burst in infected
macrophages, stimulated by ………… will eradicate the infection.

Answer 28

In mutant Listeria that lack lysteriolysin,
the oxidative burst in infected
macrophages, stimulated by CD4+ T cell
IFNg, will eradicate the infection.

Question 29

immune compromised
neonates
elderly
pregnant women
contaminated food

Answer 29

Listeria