Ch32-33 Acute Flaccid Myelitis-with highlights

Question 1

Since 2014, acute flaccid myelitis (AFM), a long-recognized condition associated
with _______, nonpolio _______, and various other viral and nonviral
causes, has been _______ globally in epidemic form

Answer 1

Since 2014, acute flaccid myelitis (AFM), a long-recognized condition associated
with polioviruses, nonpolio enteroviruses, and various other viral and nonviral
causes, has been reemerging globally in epidemic form

Question 2

Instead, the new AFM epidemic has been temporally associated
with reemergences of__________ such as _____, until recently
thought to be an obscure virus of extremely low endemicity.

Answer 2

Instead, the new AFM epidemic has been temporally associated
with reemergences of nonpolio enteroviruses such as EV-D68, until recently
thought to be an obscure virus of extremely low endemicity.

Question 3

Poliovirus isolation techniques
also led to discovery and characterization of a large, ubiquitous group of
__________ termed “enteroviruses,” containing not only the three _________ but
also at least 110 “___________” (NPEVs) (12). Unlike classical fecal-oral
transmission of polioviruses, some _______ are more commonly transmitted by the
_______ route. NPEVs can cause a wide array of disease syndromes

Answer 3

Poliovirus isolation techniques
also led to discovery and characterization of a large, ubiquitous group of
picornaviruses termed “enteroviruses,” containing not only the three polioviruses but
also at least 110 “nonpolio enteroviruses” (NPEVs) (12). Unlike classical fecal-oral
transmission of polioviruses, some NPEVs are more commonly transmitted by the
respiratory route. NPEVs can cause a wide array of disease syndromes