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MBE3 > Bacteria-Ch24-29 Spirochetes---Mycoplasma-with highlights > Flashcards

Bacteria-Ch24-29 Spirochetes---Mycoplasma-with highlights Flashcards

1
Q

Treponema pallidum

POS or Neg

A

Neg

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2
Q

What type of LPS does Terponema pallidum have?

A

It doesn’t have an LPS bro.

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3
Q

flagella (3/pole) in an axial filament (between inner &outer membrane)

A

Treponema pallidum

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4
Q

fragile (only survive transmission without exposure):
sexual and congenital (placental) transmission in body fluids and
mucous membranes

A

Treponema pallidum

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5
Q

Treponema pallidum

Virulance Factors

A

host response causes disease

symptoms

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6
Q

A new-world ® old-world

disease thanks to Columbus

A

Syphilis

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7
Q

sexual (human reservoir)
• congenital (spirochete
crosses placenta: late lethality)

A

Syphilis

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8
Q

Syphilis:

Stages….

A 
Stages:
1. local: hard chancre/ulcer at
site of infection; infectious
2.disseminated: rash, aches;
mucous membrane lesions
(“the great imitator”);
infectious
3.gummas; damage to blood
vessels, eyes, CNS;
insanity; not infectious
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9
Q

gummas

A

Stage 3. Syphilis
gummas; damage to blood
vessels, eyes, CNS;
insanity; not infectious

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10
Q

Syphillis Asymptomatic period

A

2-24 weeks.

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11
Q

Tertiary syphilis

A

Diffuse Cronic inflammation

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12
Q

Secondary syphilis

A

2-6 weeks; 50% of primary
infections go on to secondary; symptoms typically
resolve spontaneously (but recurrence in 25% with 1 yr)

Microbe persists for 2/3 of secondary infections, with 1/2
exhibiting tertiary syphilis

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13
Q

gummas

A

These form in tertiary syphilis
granuloma lesion = inflammatory mass which can perforate, e.g. roof of
mouth or any other tissues

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14
Q

[completely preventable by penicillin treatment early in pregnancy!):

A

congenital syphilis [

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15
Q

high lethality in-utero OR
when initially born without symptoms: high lethality typical of young children (e.g. 2 yrs old) with facial
and dental abnormalities like “Hutchinson’s incisors” and “mulberry molars”.

A

Syphilis

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16
Q

Treatment for 1º and 2º infections, which contain actively growing spirochetes
No vaccine

A

penicillin for 1º and 2º infections, which contain actively growing spirochetes
No vaccine

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17
Q

Borrelia
Neg or Pos?
Shape?

A

G-

Spirochete

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18
Q

Borrelia burgdorferi

what desease?

A

Lyme Desease

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19
Q

Ixodus scapularis

A

Tick involved in Lyme desease.

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20
Q

…… are responsible for spreading the majority of lyme disease infections to humans. Usually during late spring and early summer.

A

Nymphs

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21
Q

Lyme Disease: Bacterium/reservoir

A

Borrelia Burgdorferi
deers, rodents
Transmission
ticks

22
Q

Erythema
migrans
rash

A

Lyme Disease: Borrelia burgdorferi

23
Q

chronic: arthritis,
CNS paralysis (due
to persistent immune
response)(>6 months

A

stage 3 lyme desease

24
Q

disseminated: nerve
paralysis (with heart
arrhythmia)(2-8 wks

A

Stage 2 lyme desease

25
Q

Relapsing Fever

A

Borrelia spp.

26
Q

Borrelia spp.

Virulance Factor

A

Virulence Factor:
Relapsing fever due to effective
immune response to antigenic variation

27
Q

B. recurrentis

Desease

A

Body Louse
Reservor: Hue-mons
Relaspsing Fever

28
Q

B. miyamotoi
Desease
Reservoir

A

Soft shelled
Rodents Soft shelled ticks
Relasping Fever

29
Q

Rickettsia

Neg of Pos

A

G-

30
Q

obligate intracellular parasite

entry into endothelial cells, escape into cytoplasm

A

Rickettsia

31
Q 
escape
into cytoplasm by phospholipase,
slow proliferation, cell lysis and
vascular hemorrhages
(no laboratory culture)
A

Rickettsia

32
Q

GTransmission

of this zoonosis: Rickettsia

A 
wood tick (including transovarian transmission from adult ticks into tick eggs)
• reservoir: wild rodents
33
Q

Rocky Mountain spotted fever

A

Rickettsia

34
Q

Disease:
• rash of extremities, then trunk
• hemorrhagic lesions (with disseminated vascular
CTL lysis of endothelial cells) ► spots
• dissemination to heart, kidneys, etc ► shock, death
(mortality = 20-40% if no treatment)

A

Rickettisa

35
Q

Chlamydia trachomatis

Neg or Pos

A

G-

36
Q

The most frequent sexually transmitted infection (followed by
gonorrhea, AIDS and syphilis)

A

Chlamydia

37
Q

No “peptidoglycan” synthesis (although the bacterial cell wall looks ‘normal G−’), low LPS

A

Chlamydia

38
Q

Inflammatory cytokines released from infected cells cause disease
manifestations: damaging cell-mediated immune response in various
tissues.

A

Chlamydia trachomatis

39
Q

EB: epithelial cell adhesion to microvilli………………

A

RB in phagosomes (no fusion with

lysosomes) ► replication and division ► EB ► cell lysis / exocytosis

40
Q

replication and division in chlamydia

A

RB in phagosomes (no fusion with

lysosomes) ► replication and division ► EB ► cell lysis / exocytosis

41
Q

Chlamydial diseases caused by ……………….

A

Chlamydial diseases caused by CMI responses

42
Q

8 serotypes:

A

gonorrheal-like sexual disease
• Mucopurulent urethritis, cervicitis, salpingitis (fallopian tube
infection)
• mobility by adhesion to sperm (► epididymitis prostatitis in men)
• PID (pelvic inflammatory disease) ► scarring ► ectopic pregnancy
+ decreased fertility

43
Q

3 serotypes: Chlamydia

A

lymphogranuloma venereum

44
Q

4 serotypes: Chlamydia

A

trachoma (endemic chronic eye infection: blindness)

ophthalmia neonatorum with conjunctivitis and pneumonia

45
Q

no immune protection

reinfection: stronger CMI

A

Chlamydia

46
Q

Chlamydia pneumoniae Causes

A

C.pneumoniae strain causes

“walking pneumonia”

47
Q

Mycoplasma pneumoniae

Neg or Pos?

A

Non-gram straining bro.

48
Q

are smallest prokaryote (

A

Mycoplasma species are smallest prokaryote (M.
genitalium 580,070 bp – 475 genes)
strict aerobe (preference for bronchial mucosa)

49
Q

atypical, mild …….., the leading cause in schools, students,
and military: aerosol transmission in crowded conditions

no vaccination; fading protective immunity after recovery

A

Mycoplasma pneumoniae

50
Q

……………………… is also known as “walking pneumonia” because it is typically mild and without the
need for hospitalization.

A

Mycoplasma pneumonia is also known as “walking pneumonia” because it is typically mild and without the
need for hospitalization.

51
Q

Mycoplasma pneumonia vaccine or no?

A

Nah

52
Q

Which pneumonia has a vaccine

A

Pneumococcal pneumonia

MBE3 (13 decks)

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