Ch.3

Question 1

Fetus exposed to many substances as mother - including drugs take
Have classifications for risks to fetus

Answer 1

Drug therapy during pregnacy

Question 2

Susceptible to drug interactions, toxicity, unusual drug responses
Require diff dosage calcs than do adults
Ensure correct weight reported

Answer 2

Dosage calcs for pediatric pats - Considerations for neonatal and pediatric pats

Question 3

Decline in organ functioning
More likely result in AE and toxicity
Physiologic changes
Absorption
Distribution
Metabolism
Excretion

Answer 3

Considerations for older adult pats

Question 4

Functioning sev organ sys slowly decline
Major effect on disposition and action of organs
Careful monitoring and dosage adj
Consider body weight and organ functioning

Answer 4

Physiologic changes

Question 5

Reduced of both dietary nutrients and drugs
Gradual reduction in ability stomach produce hydrochloric acid
Reduction in blood flow to GI tract
Can get constipation

Answer 5

Absorption

Question 6

Reduction in total body water content with aging
Hydrophilic drugs may be higher in older adults
Reduced protein concentrations

Answer 6

Distribution

Question 7

Liver loses mass with age and slowly loses its ability to metabolize drugs effectively
Reduction in blood flow to liver

Answer 7

Metabolism

Question 8

Renal func declines
Reduc in GFR

Answer 8

Excretion