Ch 82 - Disorders of the Skin and Subcutaneous Tissues Flashcards
What tissue appears most sensitive to healing issues with chemotherapy?
At what stage post-op is it generally recommended to start chemotherapy?
- Intestinal tissue
- 7-10 days after surgery
What is the general recommendation of timing of radiation therapy before and after surgery?
- After surgery: 1-3 weeks
- Before surgery: Discontinue for 3-4 weeks (to wait for the acute radiotherapy effect to subside)
List tumour-related factors which may impact wound healing
- Residual neoplastic tissue
- Tumour-related cytokines
- Cancer cachexia
- Paraneoplastic syndromes
- Tumour size
List the 4 classifications of tumours based on cell origin
- Mesenchymal
- Epithelial
- melanocytic
- round cell
Describe the TNM staging system
What is the estimated diagnostic accuracy of FNA cytology of skin neoplasms as compared to histo?
Over 90%
How do epithelial and mesenchymal neoplasms tend to metastasise?
- Mesenchymal - haematogenous
- Epithelial - Lymphatics
What technique can be used for real-time intra-op margin assessment?
Near-infrared fluorescense imaging
What sized thoracic nodules can be detected on CT and rads?
- CT: 1-2mm
- Rads: 5-9mm
What cells make up the germinal centers of a lymph node?
B-lymphocytes and plasma cells
List some benefits of lymphadenectomy
- LN mets may act as a surce for further spread
- Could slow down rate of mets
- May reduce paraneoplastic disease
- Part of debulking procedure
- Lymphadenectomy of positive nodes concurrent with excision of grade 2 MCT significantly improved survival
What is a late sequelae of lymphangitis?
Irreversible thickening of the skin and SQ (increased macrophages and fibroblasts leading to increased collagen and progressive SQ fibrosis)
What is lymphedema?
Interstitial oedema characterised by an imbalance between net capillary filtration and lymphatic return of interstitial fluid
WIth lymphatic stasis, macromolecular proteins and metabolites accumulate in the interstitial space. This increased oncotic pressure draws more water out causing a subsequent increase in interstitia volume; hydraulic pressure. Dilation of lymph vessels may also lead to valve insufficiency (dermal backflow)
List underlying abnomalities of primary lymphoedema
- Hypoplasis, aplasia or hyperplasia of distal lymphatics
- Lymphatic valve incompetence
- hypoplastic or fibrotic lymph nodes
What are the most common skin tumours of dogs and cats?
What mutation is seen in many cases of SCC?
UV light-specific mutations in the p53 tumour suppresor gene
List the most common sites of SCC in dogs and in cats
- Dogs: nail bed, scrotum, legs, anus
- Cats: Pinnae, eyelids, temporal area, nasal planum
White cats have a 13x higher risk
List some alternative treatment methods of SCC stage Tis or T1
- Cryotherapy - small, superficial lesions up to 5mm
- Plesiotherapy (strontium 90) - superficial lesions, only 10% of original dose reaches 3mm of depth
- Radiation Therapy
- Photodynamic therapy - topical 5-aminolevulinic acis or systemic meta-tetrahydroxyphenylchlorin for superficial lesions
- Electrochemotherapy - bleomycin
- NSAIDs
- Immunomodulatory therapy - Imiquimod, indirect antiviral and antitumour effects
Aggressive surgert is best for stage T2 or higher