Ch 120 - Pheochromocytoma Flashcards

1
Q

What are the cells called which synthesise catecholamines?

A

Chromaffin cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the ratio of epinephrine:norepinephine in cats and dogs

A

Cats: 70%epi, 30% norepi
Dogs: 60% epi, 40% norepi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the rate limiting enzyme for the production of epinephrine

A

Tyrosine hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Is there atrophy of the contralateral adrenal gland with a phaechromocytoma

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the most specific test for phaeochromocytoma?

A

Urine creatine:normetanephrine ratio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What kind of drug is phenoxybenzamine?

A

Alpha-adrenergic receptor blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The use of phenoxybenzamine preoperatively has decreased perioperative mortality rate from what to what?

A

48 - 13%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What medication can be considered if persistently tachycardic pre-operatively?

A

Atenolol or propanolol (beta-adrenergic antagonist)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What medication can be used for intra-operative arterial hypertension?

A

Phentolamine (short acting alpha agonist) or nitroprusside (direct vasodilator)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What percentage of phaeochromocytomas invade the cava?

A

35-55%
(11-16% with adrenocortical tumours)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the perioperative mortality rate for phaeochromocytomas?

A

9-47%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the MST with medical management for phaeochromocytomas?

A

17.8m

How well did you know this?
1
Not at all
2
3
4
5
Perfectly