Ch 7 - Peripheral Nervous System (Exam 4) Flashcards
PNS
Nerve fibers carry info between CNS and body; Afferent-to CNS; Efferent-from CNS, Somatic-motor fibers-skeletal muscle, Autonomic-smooth muscle, cardiac muscle, glands (involuntary)-Sympathetic/Parasympathetic
ANS
Efferent division of PNS; Link between brain to body; CNS initiates action potentials in effector neuron whose axons terminate on organs; Cardiac m, smooth m, most exocrine, endocrine, adipose innervated by ANS; Neurotransmitters-Acetylcholine, Norepinephrine
Two-neuron Chain
Each autonomic nerve pathway extending from CNS to body is two-neuron chain (except medulla); cell body of 1st neuron in CNS; Axon (preganglionic fiber) synapses w cell body of 2nd neuron (w/in ganglion); Axon 2nd neuron (postganglionic fiber) innervates organ
Sympathetic ANS
Originate in thoracic and lumbar regions of spinal cord; short, complicated
Parasympathetic ANS
Arise from brain and sacral region of spinal cord; long, simple
Preganglionic Fibers
Acetylcholine
Postganglionic Fibers
Parasympathetic-Acetylcholine; Cholinergic; Most sympathetic-NE; Adrenergic
Sympathetic Dominance
Fight/flight; Inc HR, BP-vasoconstriction, bronchodilation, glycogen and fat stores broken down to gluc, dilate blood vessels to skeletal muscles, pupils dilate, sweat, inhibit GI/GU
Parasympathetic Dominance
Quiet, relaxed situations; digestion, etc
Receptors
Each autonomic neurotransmitter (and medullary hormones) stimulates activity in some tissues but inhibits in others; Particular response depends on specialization of target cells rather than properties of chemicals
Cholinergic Receptors
Acetylcholine-2 types; Nicotinic-postganglionic cell bodies of all autonomic ganglia, respond to ACh released from S and P preganglionic fibers; Muscarinic-cell membranes of smooth m, cardiac m, glands, bind w ACh released from P postganglionic fibers
Agonist
mimics neurotransmitter’s response
Antagonist
blocks neurotransmitter’s response
Salbutamol
selectively activates beta2 receptors-bronchodilation in asthma
Metoprolol
blocks beta1-treat HTN by dec amount of blood heart pumps