Ch 7 Flashcards
Neoplasia
What is the primary advantage of targeted cell therapy?
It uses drugs that selectively attack malignant cancer cells p.152
Which target of both chemo and radiation treatment accounts for adverse and therapeutic effects?
Rapidly proliferating cells p. 149
The leading cause of death in both men and women
Lung cancer p. 129
Cell proliferation means?
Increase cell numbers by mitotic cell division p. 129-130
Malignant neoplasms are more well-differentiated than benign tumors (true/false)
false p. 129-131
Do cancer cells ever die?
They differ from normal cells by being immortal and have an unlimited lifespan p. 133-135
A patient with liposarcoma has?
Malignant tumor of adipose tissue p. 131
What is a polyp?
Growth that projects from a mucosal surface p. 130
Benign tumors usually grow by expansion (true/false)
true
Explain “sentinel node”
it is used to describe the initial lymph node to which the primary tumor drains p. 135
Which tumor suppressor genes are associated with genetic susceptibility to breast cancer?
BRCA1
BRCA2
p.141
With abdominal cancer the tumor may compress the viscera which causes?
Bowel obstruction p. 144
breast tumor undetectable until it has double 30 times and contains more than 1 billion cells. Which means it measures at approx what size?
1 cm
p.134
Adult cancers differ in origin from childhood cancers by:
Adult cancer originates from epithelial cells
p.130
adolescent that had childhood cancer should include which following late therapy sequelae?
Impaired growth
Neurologic dysfunction
p.153
What is the abnormal mass of tissue in which the growth exceeds and is uncoordinated with that of the normaltissue
neoplasm p. 136
Goa of Antiangiogenesis therapy?
limit the size of a tumor by limiting its ability to recruit blood vessels p. 140
What type of tissue composes the tumor of Adenocarcinoma?
Glandular epithelium p. 130
5-fluorouracil stops normal development and division by interrupting the S phase of the cycel. Explain the S phase:
The synthesis of DNA occurs causing 2 sperate sets of chromosomes to develop p. 139
significant loss of skeletal muscle and fat can be described as:
Cachexia p. 145
What is the treatment that involves strengthening the immune system?
immunotherapy p.149-152
Risk factors for cancer:
Age Environment Genetics Heredity p. 137
Which cancers are often found because of effusions?
Lung and Ovarian cancers p. 144
Drug therapies that affect cyclins and CDS are therapeutic by:
affecting the progression of cells through the process of cell division p. 137
Carcinoma is suspected because cells possess the characteristics of:
loss of differentiation p. 132
Healthy tips for preventing cancer identifies which foods/compounds to be carcinogenic in humans?
Cigarette smoke
smoked foods
nickel compounds
p. 142
Definition of anaplasia
loss of cell differentiation in cancerous tissue
Cancers have been identified as inheritable through autosomal dominant gene. Which cancer carries the highest risk in someone who carries the gene?
Colon cancer p. 141
radiation therapy is the best course of treatment for:
radiosensitive tumors that are fast growing p. 149
Screening mechanisms are available for which cancers?
Breast
Cervical
prostate p. 147
Three stages that cause normal cells to become cancerous:
Initiation
Promotion
progression
p. 147-149
Which factors are high-risk and associated with cancer development?
hormonal factors heredity environmental agents immunologic mechanisms p.144
drinking and smoking puts patients at risk for which cancers:
Laryngeal
esophageal
oral
breast cancer staged as T3, N0, M0, what does this mean?
sizeable tumor but no lymphatic involvement p. 149
Cancer-associated genes can be classified into which broad categories:
Gene overactivity
Gene underactivity
p. 137-140
