ch 66 Flashcards
zofran common side effects
headache
diarrhea
dizziness
prolongs QT
zofran is more effective when combined with
dexamethasone
Aprepitant (emend) is approved for
preventing post-op n/v (PONV) and CINV (chemo induced n/v)
has to be given with another antiemetic (glucocorticoid such as dexamethasone) or serotonin antagonist (zofran)
suffix for Substance P/Neurokinin-1 Antagonist
-pitant
aprepitant
rolapitant
netupitant
fosaprepitant
adverse effects of Aprepitant (emend)
combining with zofran and dex - more fatigue and asthenia (muscle weakness), dizziness, diarrhea
and transient elevation of circulation aminotransferases ->could indicate liver injury
Drug interactions for Aprepitant (emend)
inducer of CYP
inhibitors (itraconazole, ritonavir) can raise levels of aprepitant
can also raise levels of chemo cancer drugs
can raise levels of glucocorticoids to prevent CINV
can induce CYP2d6
decrease levels of warfarin, ethinyl estradiol (birth control)
what benzodiazepine is used for antiemetic in CIMV
lorazepam (ativan)
Promethazine (phenergan) side effecct
resp depression
local tissue injury
what 2 Butyrophenones are used as antiemetics
used for
side effects
Haloperidol (haldol)
droperidol
used for postop n/v and emesis caused by cancer therapy
extrapyramidal reactions
sedation
hypotension
droperidol - QT prolongation
what prokinetic agent used for an antiemetic
used in
Metoclopramide (Reglan)
suppress postop nausea/vomiting as well as emesis caused by anticancer drugs, opioids, toxins and radiation
chemotherapy is associated with 3 types of emesis
anticipatory
acute
delayed
emesis that begins within minutes to a few hours after receiving chemotherapy and often resolves within 24 hours
acute emesis
emesis that develops a day or more after drug administration
delayed emesis
when are antiemetics more effective in CINV
more effective prevention than at suppressing
the current regimen of choice for a pt taking highly emetogenic drugs consists of 3 agents
aprepitant
dexamethasone
5HT3 antagonist (ie) ondansetron and palonosetron)
a severe form of n/v of pregnancy (NVP) , characterized by dehydration, ketonuria, hypokalemia, loss of 5% or more of body weight
hyperemesis gravidarum
nondrug measures for managing NVP
eating small portions of food throughout the day
avoid odors, foods and supplements that can trigger NVP (fatty foods, spicy foods, iron tablets)
use of alternative treatments such as acupuncture and ginger
first line therapy for NVP consists of what
2 drug combo
doxylamine plus vit B6 (pyridoxine) - the combo is sold as Diclegis
other drugs for NVP is
prochlorperazine
metoclopramide
zofran
age for Promethazine
2 and older