ch 22

Question 1

a group of movement disorders of CNS orgin. Characterized by heightened muscle tone, spasm and loss of dexterity

Answer 1

Spaticity

Question 2

The most common causes of spaticity are

Answer 2

Multiple sclerosis
Cerebral palsy

other causes are
traumatic spinal cord lesions and stroke

Question 3

what drugs are approved for spasticity

Answer 3

Baclofen
Diazepam
Dantrolene
Tizanidine

Question 4

which spasticity drug acts directly on skeletal muscle

Answer 4

Dantrolene

Question 5

Baclofen is approved in relieving spasm r/t only

Answer 5

MS

spinal cord injuries

Question 6

most common side effect of Baclofen

Answer 6

drowsiness
dizziness
weakness 
fatigue
hypotension

start small and go slow

Question 7

overdose of Baclofen

Answer 7

coma

resp depression

Question 8

antidote for Baclofen overdose

Answer 8

none

supportive care

Question 9

oral Baclofen withdrawal symptoms

Answer 9

visual hallucinations
paranoid ideation
seizures

withdrawal over 1-2 weeks

Question 10

intrathecal baclofen withdrawal symptoms

Answer 10

high fever
AMS
exaggerated rebound spasticity
muscle rigidity

rare cases -> rhabdomyolysis ->multiorgan system failure and death

Question 11

adverse effects Baclofen

Answer 11

nausea
vomiting
constipation
urinary retention