Ch. 6 morphology boxe Flashcards
What is the principal morphologic manifestation of immune complex injury?
acute vasculitis associated with necrosis of the vessel wall and intense neutrophilic infiltration
In immune complex injury, what do the necrotic tissue and deposits of immune complexes, complement, and plasma protein appear as?
smudgy eosinophilic area of tissue destruction termed Fibrinoid necrosis
The most characteristic lesions of SLE resylt from immune complex deposition in what?
- blood vessels
- kidneys
- connective tissue
- skin
In Sjogren Syndrome, what is the earliest histologic finding in both the major and minor salivary glands?
perductal and perivascular lymphocytic infiltration
In Sjogren Syndrome, what may be seen in the larger salivary glands?
lymphoid follicles with germinal centers
What may the ductal lining epithelial cells show in Sjogren syndrome?
hyperplasia, thus obstructing the ducts
in Sjogren Syndrome, explain the course of the disease after hyperplasia
-Atrophy of the acini, fibrosis, and hyalinization; still later, atrophy and replacement of parenchyma with fat
Other physical manifestations of Sjogren Syndrome
- lack of tears leads to drying of corneal epithelium which becomes inflamed, eroded, and ulcerated
- oral mucosa may atrophy, with inflammatory fissuring and ulceration
- Dryness and crusting of the nose may lead to ulcerations and even perforation of the nasal septum
Describe the fingers in the advanced stages of Systemic sclerosis
tapered claw-like appearance with limitation of motion in joints. may have cutaneous ulcerations and sometimes tips will undergo autoamputation
In Sytemic Sclerosis, which part of the alimentary tract develops the worst progressive atrophy and collagenous fibrous replacement of the muscularis?
esophagus
what is the anatomic basis for the malabsorption syndrome sometimes encountered in systemic sclerosis?
loss of villi and microvilli in the small bowel
