Ch. 6 - Depressive and Bipolar Disorders Flashcards
Explain a major depressive episode.
a period of 2 or more weeks marked by at least 5 symptoms including delusions or hallucinations
Explain major depression disorder.
major depressive disorder w/out a history of mania; seasonal; catatonic, 2 weeks at least
What is the difference between depression and mania?
depression: low, dark and challenges are overwhelming
mania: breathless euphoria or frenzied energy that may be exaggerated
Explain unipolar depression.
- no history of mania
- suffer from only from depression
- return to normal or nearly normal mood when their depression lifts
Explain bipolar disorder.
periods of mania that alternate with periods of depression
What are types of unipolar depressive disorders?
- major depressive disorder
- persistent depressive disorder
- premenstrual dysphoric disorder
Explain persistent depressive disorder
- person experiences symptoms for at least 2 years
- no history of mania or hypomania
What are 2 kinds of depression?
- reactive (exogenous)
- endogenous
Explain the biochemical factor within unipolar depression.
- low activity of two neurotransmitters: norepinephrine and serotonin
- glutamate could be included
- release of hormones at various locations throughout body -> HPA pathway
Explain how brain circuits are impacting depression?
- subgenual cingulate makes a distinct contribution
- brain cicuit dysfunction
- abnormal activity and flow rate in various brain locations
What do MAO inhibitors do?
increases activity level of neurotransmitters serotonin and norepinephrine by blocking MAO’s
What do tricyclics do?
acts neurotransmitter reuptake mechanism of key neurons; biological corrections
What are the second-generation antidepressants?
- selective serotonin reuptake inhibitors (SSRIs) - increase serotonin w/out other neurotransmitters
- selective norepinephrine reuptake inhibitors: increase norepinephrine only
- selective-norepinephrine reuptake inhibitor
What are ketamine-based antidepressants?
- increases activity of glutamate in brain; may aid in neural pathway development
- alleviates depression quickly
What is vagus nerve stimulation?
an implanted pulse generator that sends electrical signals to the vagus nerve which then delivers electrical signals to the brain