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ns and behavior > Ch 6 > Flashcards

Ch 6 Flashcards

1
Q

What are the components of a synapse?

A

Presynaptic terminal
Postsynaptic terminal
Synaptic cleft

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2
Q

What are the steps of synaptic communication?

A
  1. action potential at presyn terminal
  2. membrane depolariz (Ca channel open)
  3. Ca -> synaptic vesicles go to release site
  4. synaptic vesicles release NT
  5. NT diffuses across synaptic cleft
  6. Nt -> receptor
  7. receptor changes shape (open channel assoc w/ receptor or activate intracellular messenger associated w/ receptor)
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3
Q

EPSP

A

Excitatory postsynaptic potential

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4
Q

T/F: EPSP causes hyperpolariz

A

F: ESPS causes depolarization (ion channel open -> less negative)

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5
Q

EPSP involves flow of Na+ and Ca2+ ___ neuron

A

Into

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6
Q

Every action potential in a ___ neuron elicits an EPSP

A

Motor

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7
Q

IPSP causes ___

A

Hyperpolariz

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8
Q

T/F: IPSP involve flow of Cl- into cell and K+ out of cell

A

T

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9
Q

T/F: EPSP = depolarization (less negative -> action potential), and IPSP = hyperpolarization (more negative)

A

T

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10
Q

Presynaptic facilitation = ___ NT released, presyn inhibition =___ NT released

A

More
Less

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11
Q

FM IL

A

presynaptic Facilitation -> More
presynaptic Inhibition -> Less

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12
Q

T/F: presyn facilitation = hyperpolarization

A

F: depolarization

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13
Q

Define neuromessenger agonist

A

When drug binds- receptor and mimics effect of naturally occurring messengers

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14
Q

Define neuromessenger antagonist

A

When drug prevents release of neuromessengers or binds to receptor and slows effect of naturally occuring messenger

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15
Q

Acetylcholine (ACh) receptors

A
  • nicotinic
  • muscarinic
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16
Q

Acetylcholine (ACh) common sites/actions

A
  • neuromuscular junction/excitatory
  • PNS regulation
  • limbic system/arousal
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17
Q

Acetylcholine (ACh) agonists

A
  • nicotine
  • muscarine
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18
Q

Acetylcholine (ACh) antagonists

A
  • curare
  • atropine
  • Botox
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19
Q

Acetylcholine (ACh) clinical applications

A
  • Myasthenia gravis
  • Alzheimer’s
  • smoking
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20
Q

Norepinephrine (NE) receptors

A
  • α1, α2
  • β1, β2
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21
Q

Norepinephrine (NE) common sites/actions

A
  • sympathetic stimulation
  • cortex and limbic system/focus and mood
22
Q

Norepinephrine (NE) agonists

A
  • amphetamines
  • cocaine
23
Q

Norepinephrine (NE) antagonists

A

propranolol

24
Q

Norepinephrine (NE) clinical applications

A
  • cardiac (β blockers)
  • panic attacks
25
Q

Dopamine (DA) receptors

A

D1, D2, D3, D4, D5

26
Q

Dopamine (DA) common sites/actions

A
  • limbic system/pleasure and addiction
  • basal ganglia/movement and goal directed behavior
  • frontal lobe/planning
27
Q

Dopamine (DA) agonists

A
  • L-dopa
  • amphetamines
  • cocaine
28
Q

Dopamine (DA) antagonists

A

antipsychotics

29
Q

Dopamine (DA) clinical applications

A
  • drug addiction
  • Parkinson’s disease
  • ADHD
  • schizophrenia
30
Q

GABA receptors

A
  • GABA 1
  • GABA 2
31
Q

GABA common sites/actions

A

cerebellum and spinal cord/primary inhibitory transmitter

32
Q

GABA agonists

A
  • benzodiazepines
  • baclofen
33
Q

GABA clinical applications

A

Baclofen pumps for spasticity

34
Q

Glutamate receptors

A
  • NMDA
  • AMPA
  • kainate
35
Q

Glutamate common sites/actions

A

CNS/mainly excitatory

36
Q

Glutamate antagonists

A

phencyclidine

37
Q

Glutamate clinical applications

A
  • excitotoxicity
  • seizure activity
38
Q

Glycine receptors

A

glycine

39
Q

Glycine common sites/actions

A

spinal cord/inhibition

40
Q

Glycine antagonists

A

strychnine

41
Q

Endorphins (opiods) receptors

A

μ1, μ2, δ, k1, k2 (G proteins)

42
Q

Endorphins (opiods) common sites/actions

A

CNS/inhibition of pain signaling

43
Q

Endorphins (opiods) agonists

A
  • opium
  • morphine
  • heroin
  • methadone
  • fentanyl
  • hydrocodone
  • oxycodone
44
Q

Endorphins (opiods) antagonists

A

naloxone

45
Q

Endorphins (opiods) clinical applications

A

pain management

46
Q

Serotonin (5-HT) receptors

A
  • 5-HT1
  • 5-HT2
  • 5-HT3
47
Q

Serotonin (5-HT) common sites/actions

A

CNS/regulation of sleep, appetite, arousal, pain, perception, and mood

48
Q

Serotonin (5-HT) agonists

A

antidepressants (reuptake inhibitors)

49
Q

Serotonin (5-HT) clinical applications

A
  • depression
  • OCD
50
Q

Substance P receptors

A

NK1

51
Q

Substance P common sites/actions

A
  • mainly excitatory
  • PNS/pain
  • CNS/cardiovascular regulation, mood, pain
52
Q

Substance P clinical applications

A

pathologic pain

ns and behavior (7 decks)

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