Ch. 37 - Legionella Flashcards

0
Q

Legionella pneumophila pathogenesis

A

Inhalation (resp disease)

Intracellular
Inhibit phagolysosome fusion

Macs secrete cytokines (inflammation)

Enzyme production (kill host cell upon lysis of intracellular vacuole)

Cell-mediated immunity (humoral minor)

Found in water
Survived chorine and high temps

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1
Q

Legionella pneumophila

A

Thin pleomorphic G-b

Obligate aerobes

NFB
Amino acid metabolism

90% disease

Serotypes 1-6

Fastidious - cysteine & iron (sucks iron out of cells –> virulence)

GS poor, use tissue silver stain

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2
Q

Legionella pneumophila disease

A

Mostly asymptomatic lung infection

Pontiac fever - self-limiting fever antib treatment

Legionnaires disease - legionellosis; systemic, multi organ disease, pneumonia, 15% healthy and 75% not will die

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3
Q

Legionella pneumophila diagnosis

A

Tissue silver stain

Antibody fluorescence

Urine Ag test

ELISA
4X or more Ab titer

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