Ch. 37 - Legionella Flashcards
Legionella pneumophila pathogenesis
Inhalation (resp disease)
Intracellular
Inhibit phagolysosome fusion
Macs secrete cytokines (inflammation)
Enzyme production (kill host cell upon lysis of intracellular vacuole)
Cell-mediated immunity (humoral minor)
Found in water
Survived chorine and high temps
Legionella pneumophila
Thin pleomorphic G-b
Obligate aerobes
NFB
Amino acid metabolism
90% disease
Serotypes 1-6
Fastidious - cysteine & iron (sucks iron out of cells –> virulence)
GS poor, use tissue silver stain
Legionella pneumophila disease
Mostly asymptomatic lung infection
Pontiac fever - self-limiting fever antib treatment
Legionnaires disease - legionellosis; systemic, multi organ disease, pneumonia, 15% healthy and 75% not will die
Legionella pneumophila diagnosis
Tissue silver stain
Antibody fluorescence
Urine Ag test
ELISA
4X or more Ab titer