Ch. 33 - Aerobic, non-fermentative, G-b Flashcards
Psuedomonas characteristics
motile G-b OXI + capsule (mucoid) *loves moisture* (hospital environment) Opportunistic
Pseudomonas pathogenesis
- adhesins (flagella and pili)
- alginate
- LPS
- toxins & enzymes - exotoxin A, pyocyanin, pyoverdin, Las A andB, Alkaline protease, phospholipase C, Exoenzymes S - and T
- antibiotic resistance
Pseudomonas Disease
- *Pulmonary
- Skin and soft tissue
- Folliculitis
- Osteochondritis
- UTI
- External Otitis
- Malignant External Otitis
- Chronic otitis media
- Eye infections
- Bacteremia
Pseudomonas aeruginosa characteristics
G-b OXI + Motile SAe green colonies grape-like odor flat, b-hem colonies
Pseud. aeruginosa diseases
Pulmonary
Chronic otitis media
Exotoxin A (Pseud)
disrupts protein synthesis
cause of dermatonecrosis in burn pts.
pyocyanin (pseud)
catalyzes H2O2 and superoxide production
stimulates IL-8 –> neutrophils
pyoverdin (pseud)
binds iron for metabolism
regulates exotoxin A secretion
Las A and Las B (pseud)
degrade elastin in tissues
degrade complement
spread of infection
Alkaline protease (pseud)
tissue destruction and spread
Phospholipase C (pseud)
degrades lipids and lecithin–> tissue destruction
Pseud. antibiotic resistance
mutation of pore proteins restrict antibiotic entry into cell
resistance to different classes of antibiotic at the same time
Burkholderia cepacia
G-b OXI + Aerobic opportunistic; low virulence colonize resp. compromised (CF) UTI, septicemia (catheters)
Burkholderia pseudomallei
G-b OXI + Aerobic opportunistic Melioidosis Inhalation (pulmonary disease and sepsis) cutaneous inoculation (lymphadenitis, fever, malaise) biological warfare
Stenotrophomonas maltophilia
G-b OXI - * NFB Aerobic Nosocomial Bacteremia and pneumonia (device associated) ^ death rate ^ resistant to antibiotics