Ch 3 Pharmacodynamics Flashcards
an agonist drug does what to the cell
changes the target cell in a “productive fashion”
an antagonist drug does what to the cell
blocks the receptor, or causes an “unproductive” change in the cell
receptors can be ___ or ___ or ___
on the cell surface
in the cytoplasm
in the nucleus
the drug is considered a ___; it binds to the receptor
ligand
Bolus dose
single dose response
4 types of dose for drugs
single dose
multiple dose
loading dose
maintenance dose
single dose vs multiple dose response
single dose is once in large quantity and maximal response is achieved
vs
multiple dose is taken several times a day and it takes time to reach a steady state
which dose is better for strong fast effect?
single dose response
how do you maintain the effect overtime?
loading dose + maintenance dose= large first dose followed by smaller multiple doses
what is the advantage of multiple dose vs single dose
avoids taking large dose so decrease the chance of toxicity and avoid the peak from large dose
ED50
effective dose fifty
= amount of drug that produces response in 50% of population
LD50
lethal dose fifty
= amount of drug that will kill half the population
TD50
toxic dose fifty
= produce a specific toxic effect in 50% of the population
TI
therapeutic index
= LD50/ED50 compares how dangerous the drug is, to how effective the drug is
the ____ the TI, the safer the drug
LARGER
