Ch. 26 Coagulation Modifiers Review

Question 0

Overlapping of heparin and ____ (Coumadin) is done purposefully to allow time for the blood levels of ____ to rise, so that when the heparin is eventually discontinued, therapeutic ____ levels of ____ will have been achieved.

Answer 0

Warfarin; warfarin; anticoagulation; warfarin

Question 1

The full therapeutic effect of warfarin does not occur until ___ to ___ days after the first dose.

Answer 1

4; 5

Question 2

Bleeding, internal and superficial, as well as____ is the most common undesirable effects of thrombolytic therapy.

Answer 2

Intercranial

Question 3

Vitamin k is given to reverse the anticoagulation affects of warfarin ____.

Answer 3

Therapy

Question 4

____ ____ is the antidote for heparin overdose.

Answer 4

Protamine sulfate

Question 5

Aspirin can alter liver, renal, and ____ functions, and laboratory studies should be performed to ____ these functions.

Answer 5

Clotting; monitor

Question 6

Aspirin should be taken with food to reduce ____ upset, and enteric coated tablets should not be ____.

Answer 6

Gastric; crushed

Question 7

Risk for ____ increases with aspirin therapy, even at low-doses.

Answer 7

Bleeding

Question 8

So I’m bulimic drugs lyse, or ____, thrombi.

Answer 8

Breakdown

Question 9

Ongoing aPTT values are used to monitor ____ therapy.

Answer 9

Heparin

*aPTT= activated partial thromboplastin time- The time needed for plasma to form a fibrin clot after the addition of calcium in the phospholipid regent; used to evaluate the intrinsic clotting system

Question 10

PR-INR is used to monitor ____ therapy.

Answer 10

Warfarin

*PT-INR = prothrombin time and international normalized ratio- measures how quickly blood clots, INR are standard units

Question 11

____ is used for long-term anticoagulation therapy; while ____ is used for short term.

Answer 11

Heparin; warfarin

Question 12

Anticoagulants ____ thrombus formation but don’t dissolve or stabilize an existing ____.

Answer 12

Preevent; thrombus

Question 13

Capsicum pepper, feverfew, garlic, ginger, ginkgo, and ginseng are some herbals that have potential ____ with anticoagulants, especially with ____.

Answer 13

Interactions; warfarin

Question 14

Acetaminophen should be safe in ____ doses; high doses, however, as well as other NSAIDs and aspirin, may cause an ____ anticoagulant effect.

Answer 14

Regular; increased

Question 15

A normal INR (Without warfarin) is ____, whereas a therapeutic INR (with warfarin) ranges from ___ to ___ , Depending on the indication for use of the drug (e.g., Atrial fibrillation, thrombosed prevention, prosthetic heart valve).

Answer 15

1.0; 2 to 3.5