Ch. 22: Introduction to Increased Destruction of Erythrocytes

Question 1

This term refers to increased destruction (i.e. lysis) of RBCs, shortening their lifespan.

Answer 1

Hemolysis or Hemolytic disorder

Question 2

The reduced number of cells due to hemolysis or hemolytic disorder results in:
(reduced/increased) tissue oxygenation
(reduced/increased) erythropoietin production by he kidney.

Answer 2

Reduced

Increased

Question 3

A hemolytic process is present without anemia if the _____ is able to compensate by accelerating RBC production sufficiently to replace the RBCs lost through hemolysis.

Answer 3

Bone marrow

Question 4

This results when the rate of RBC destruction exceeds the increased rate of RBC production.

Answer 4

Hemolytic anemia

Question 5

What are the classifications of anemias when hemolysis is the primary feature?

Answer 5

Acute vs Chronic
Inherited vs Acquired
Intrinsic vs Extrinsic
Intravaascular (Fragmentation) vs Extravascular (Macrophage-mediated)

Question 6

This type of anemia has a rapid onset and is isolated (sudden), episodic, or paroxysmic.

Answer 6

Acute hemolysis

Question 7

Give two specific acute anemias.

Answer 7

Paroxysmal cold hemoglobinuria

Paroxysmal nocturnal hemoglobinuria

Question 8

This is a type of acute anemia wherein the patient will experience hemolysis only after exposure to cold.

Answer 8

Paroxysmal cold hemoglobinuria

Question 9

This is a type of acute anemia wherein the patient will experience hemolysis while sleeping.

Answer 9

Paroxysmal nocturnal hemoglobinuria

Question 10

These are a type of drug that are oxidizing agents and cause a dramatic acute hemolytic event.

Answer 10

Antimalarial drugs

Question 11

Give a disease wherein chronic conditions result in anemia that is so severe that the bone marrow cannot regenerate cells fast enough to compensate for the anemia.

Answer 11

Thalassemia