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Hematology > Ch. 14 - RBC Indices > Flashcards

Ch. 14 - RBC Indices Flashcards

0
Q

Why are the RBC Indices calculated?

A

To determine the size and hemoglobin content of the average RBC.
For quality control check
To differentiate anemias

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1
Q

What are the RBC Indices?

A

Mean Cell Volume
Mean Cell Hemoglobin
Mean Cell Hemoglobin Concentration

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2
Q

The RBC indice that is the average volume of the RBC

A

Mean Cell Volume

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3
Q

What is the unit used to express MCV?

A

Femtoliters (fL), or 10^-15 L

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4
Q

What is the formula for MCV?

A

MCV =

Hct (%) x 10/RBC count (x 10^12/L)

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5
Q

What is the reference range for MCV?

A

80 - 100 fL

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6
Q

What is the term used to describe RBCs with an MCV of less than 80fL?

A

Microcytic

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7
Q

What is the term used to describe RBCs with an MCV of more than 100fL?

A

Macrocytic

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8
Q

The RBC indice that is the average weight of hemoglobin in an RBC

A

Mean Cell Hemoglobin (MCH)

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9
Q

What unit is used to express MCH?

A

Picograms (pg), or 10^-12 g

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10
Q

What is the formula used to calculate MCH?

A

MCH =

Hb (g/dL) x 10/RBC count (x 10^12/L)

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11
Q

What is the reference range for MCH for adults?

A

28 - 32 pg

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12
Q

Which among the RBC indices is not considered in the classification of anemias?

A

MCH

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13
Q

The RBC indice that is the average concentration of hemoglobin in each individual erythrocyte.

A

Mean Cell Hemoglobin Concentration (MCHC)

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14
Q

What is the unit used to express MCHC?

A

Grams per deciliter (formerly given as percentage)

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15
Q

What is the formula used to calculate MCHC?

A

MCHC =

Hb (g/dL) x 100/Hct (%)

16
Q

MCHC values of normochromic cells range from _____

A

32 to 36 g/dL

17
Q

What are the MCHC values of hypochromic cells?

A

Less than 32 g/dL

18
Q

What are the MCHC values of hyperchromic cells?

A

Greater than 36 g/dL

19
Q

Among the different types of cells classified under MCHC, which is a misnomer?

A

Hyperchromic cells

20
Q

What makes the hyperchromic cells a misnomer?

A

A cell does not really contain more than 36 g/dL of hemoglobin, but its shape may have become spherocytic, which makes the cell appear full.
Possible error in hemoglobin value
Presence of cold agglutinin

21
Q

What can be done to produce accurate results for a specimen showing hyperchromic cells due to cold agglutinin?

A

Incubate the specimen at 37 C for 15 mins.

22
Q

The following data could be caused by what diseases?
MCV <32
RBC Morphology:
Microcytic; Hypochromic

A 
Iron deficiency anemia
Thalassemia
Sideroblastic anemia
Other condition of defective iron use
Chronic infection or inflammation
Unstable hemoglobins
23
Q 
The following data could be caused by what diseases?
MCV    80 - 100
MCHC 32 - 36
RBC Morphology:
Normocytic; Normochromic
A 
Hemolytic anemia
Leukemia
Metastatic malignancy
Bone marrow failure
Chronic renal disease
24
Q 
The following data could be caused by what diseases?
MCV    >100
MCHC 32 - 36
RBC Morphology:
Macrocytic; Normochromic
A

Megaloblastic anemias
Liver disease
Myelodysplasias

25
Q

What is the RBC morphology of cells with:

MCV <32

A

Microcytic; Hypochromic

26
Q

What is the RBC morphology of cells with:
MCV 80 - 100
MCHC 32 - 36

A

Normocytic; Normochromic

27
Q

What is the RBC morphology of cells with:
MCV >100
MCHC 32 - 36

A

Macrocytic; Normochromic

28
Q 
MCV    <32
These results can usually be found in the following diseases except:
Iron deficient anemia
Thalassemia
Unstable hemoglobins
Myelodysplasias
A

Myelodysplasias

29
Q 
MCV    80 - 100
MCHC 32 - 36
These results can usually be found in the following diseases except:
Hemolytic anemia
Leukemia
Chronic infection or inflammation
Chronic renal disease
A

Chronic infection or inflammation

30
Q 
MCV    >100
MCHC 32 - 36
These results can usually be found in the following diseases except:
Megaloblastic anemia
Liver disease
Sideroblastic anemia
A

Sideroblastic anemia

Hematology (13 decks)

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