ch 16: sensory, motor and integrative systems Flashcards

1
Q

sensation vs perception

A

Perception is the conscious awareness & interpretation of a sensation
◦ Perception of a sensation involves the cortex
◦ precise localization & identification
◦ memories of sensations are stored in cortex

Sensation is any stimuli the body is aware of (consciously or not)
◦ Chemoreceptors, thermoreceptors, nociceptors, baroreceptors
◦ What are we not aware of?
◦ X-rays, ultra high frequency sound waves, UV light
◦ We have no sensory receptors for those stimuli

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2
Q

what is sensory modalities? What are the two classes?

A

Sensory Modality is a type of sensation
◦ a given sensory neuron carries information for only one sensory modality
◦ touch, pain, temperature, hearing, vision, are all different sensory
modalities
Two classes of sensory modalities
◦ general senses (somatic and visceral senses)
◦ special senses (smell, taste, vision, hearing, and equilibrium)

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3
Q

what are the 4 steps in the process of sensation

A
  1. Stimulation of sensory receptors - Each receptor only responds to one type of stimulus
  2. Transduction of the stimulus = conversion into a graded potential
    Graded potentials vary in amplitude depending on the strength of the
    stimulus and are not propagated
  3. Generation of nerve impulses when the graded potential reaches threshold,
    an action potential is triggered neurons that conduct nerve impulses from PNS
    directly to CNS are called first-order neurons
  4. Integration of sensory information A specific part of CNS receives and integrates the
    sensory nerve impulses
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4
Q

what are free nerve endings? what are they useful for?

A

Free nerve endings are the dendrites of first-order neurons

For the sensations of pain, temperature, tickle, itch &
light touch, and smell

The graded potential triggered in a neuron with free nerve endings is
called a generator potential

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5
Q

describe encapsulated nerve endings

A

Receptors for pain, temperature, tickle, itch, and some touch sensations are free nerve endings. Receptors for other somatic and visceral sensations, such as pressure, vibration, and some touch sensations, are encapsulated nerve endings.

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6
Q

what are separate sensory cells

what does the graded potential trigger?

What does the receptor potential trigger

A

used for vision (photoreceptors), taste (gustatory receptor cells), hearing and equilibrium (hair cells)
these cells synapse with fist-order neurons

the graded potential triggered in a sensory cell is called a receptor potential

the receptor potential triggers the release of neurotransmitters onto the first-order neuron

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7
Q

generator vs receptor potential

true or false they are both graded?

A

Generator potential
◦ Triggers an AP in the 1st order neuron
◦ E.g., Free nerve endings, encapsulated nerve endings & olfactory receptors
Receptor potential
◦ Receptor cells release neurotransmitter molecules on first-order neurons
producing postsynaptic potentials → PSP may trigger a nerve impulse
◦ E.g. Vision, hearing, equilibrium and taste receptors produce receptor
potentials

Both are GRADED → Amplitude of potentials vary with stimulus intensity

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8
Q

A generator potential produces action
potentials and a receptor potential causes
release of neurotransmitters.
a) True
b) False

A

true

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9
Q

Separate sensory cells are different from other
sensory receptors in that
a) Separate sensory cells are part of the first-order neuron
b) Separate sensory cells are part of the dendrites of first-order
neurons
c) When separate sensory cells are involved, first-order neurons are
not required
d) Separate sensory cells synapse onto first-order neurons

A

D

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10
Q

where are exteroceptors located? what do they do

A

(outside)

◦ Located near surface of body
◦ receive external stimuli
◦ hearing, vision, smell, taste, touch, pressure, pain, vibration & temperature

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11
Q

where are interoceptors located? what do they do?

A

(inside)

Located in and monitor internal environment (BV, viscera, muscles, nervous
system)
◦ not consciously perceived except for pain or pressure

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12
Q

where are proprioceptors found and what do they do?

A

Located in muscles, tendons, joints & inner ear
◦ sense body position & movement

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13
Q

what do mechanoreceptors detect?

A

◦ detect mechanical stimuli (eg. deformation, stretching, bending)
◦ touch, pressure, blood pressure, vibration, proprioception, hearing and equilibrium

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14
Q

what do thermoreceptors detect

A

changes in temperature

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15
Q

what do nociceptors detect

A

damage to tissue = pain

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16
Q

what do photoreceptors detect?

A

light

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17
Q

what do chemoreceptors detect

A

molecules

taste, smell and changes in body fluid chemistry

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18
Q

what do osmoreceptors detect?

A

detect osmotic pressure in fluids

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19
Q

how do most sensory receptors exhibit adaptation

A

the tendency for the generator or receptor potential to decrease in amplitude
during a maintained constant stimulus
◦ because of adaptation, the perception of a sensation may fade or disappear
even though the stimulus persists

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20
Q

what are the different types of variability in the tendency to adapt?

A

◦ Rapidly adapting receptors (eg. smell, pressure, touch)
◦ specialized for detecting changes in a stimulus
◦ Slowly adapting receptors (eg. pain, body position)
◦ nerve impulses continue as long as the stimulus persists – Pain is not easily
ignored

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21
Q

Which of the following primarily consists of
slowly adapting sensory receptors?
a) Body position
b) Touch
c) Pressure
d) Smell

A

A) body position

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22
Q

Which of the following somatic sensations
has an encapsulated nerve ending as its
sensory receptor?
a) tickle
b) pain
c) heat or cold
d) pressure
e) itch

A

d) pressure

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23
Q

what are the different types of somatic sensations

A
  1. TACTILE SENSATIONS
  2. THERMAL SENSATIONS
  3. PAIN SENSATIONS
  4. PROPRIOCEPTIVE SENSATIONS
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24
Q

describe the corpuscle of touch (Meissner corpuscle)

what doe they detect

A

Corpuscle of touch (Meissner corpuscle) are
encapsulated nerve endings located in the dermal
papilla of hairless skin (fingertips, hands, eyelids,
tip of tongue, lips, nipples, soles, clitoris and tip of
penis). They are sensitive and rapidly adapting

Detect: pressure, lower-frequency vibrations

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25
describe the hair root plexuses what do they detect?
Hair root plexuses are rapidly adapting free nerve endings wrapped around hair follicles (dermis). They detect hair movements, itch, tickle sensations
26
Type I cutaneous mechanoreceptors (Merkel tactile discs) what do they detect?
Type I cutaneous mechanoreceptors (Merkel tactile discs) are slowly adapting free nerve endings located in the dermal papilla (fingertips, hands, lips, external genitalia). They make contact with Merkel cells from the stratum basale Detect: pressure, itch, tickle
27
type II cutaneous mechanoreceptors (Ruffini corpuscles)
Type II cutaneous mechanoreceptors (Ruffini corpuscles) are slowly adapting encapsulated nerve endings located deep in the dermis, ligaments and tendons. Sensitive to stretching as digits and limbs move.
28
define pressure
involves sustained deformation in deep tissues felt over larger area than touch
29
describe lamellated (Pacinian) corpuscles what do they detect?
Lamellated (Pacinian) corpuscles are encapsulated nerve endings widely distributed in the body (deep in the dermis and subQ layer; mucous and serous membranes; joints, tendons, muscles; periosteum; mammary glands, external genitalia and some viscera Detect: higher-frequency vibrations
30
define vibration
involves rapidly repetitive sensory signals from tactile receptors
31
define itch
stimulation of free nerve endings by certain chemicals (often released during an inflammatory response)
32
define tickle
stimulatikon of free nerve endings that occurs only when someone else touches you
33
what is phantom limb sensations
When sensations (often pain) are coming from an amputated limb (which, obviously, isn’t there) Could be due to sectioned neurons remaining in the stump, which get activated Could be due to rewiring of the brain, leading to stimulations from other parts of the body being perceived as coming from the amputated limb Traditional pain medicine ineffective Alternative therapies more promising (mirror therapy, electrical nerve stimulation, acupuncture, biofeedback)
34
Which somatic sensory receptor is rapidly adapting and responsible for fine touch? a) type I cutaneous mechanoreceptor b) lamellated corpuscle c) nociceptor d) corpuscle of touch e) type II cutaneous mechanoreceptor
d) corpuscle of touch
35
describe thermal sensations and where receptors are found
Free nerve ending receptors on the skin surface ◦ Cold receptors in the stratum basale (100C to 400C) ◦ Warm receptors in the dermis (320C to 480C) Both adapt rapidly at first, but continue to generate impulses at a low frequency Pain receptors rather than thermoreceptors are activated below 100C and over 480C
36
describe pain sensations. Which ones are the pain receptors?
Pain is a sensation necessary for survival – signals the presence of tissuedamaging conditions ◦ stretching, prolonged muscular contractions, muscle spasms, ischemia Pain receptors (nociceptors) are free endings that are located in nearly every body tissue (except brain) ◦ adaptation is slight if it occurs at all
37
what happens when tissue injury occurs
Tissue injury releases chemicals that stimulate nociceptors ◦ e.g. prostaglandins, kinins, potassium ◦ pain may remain even after stimulus is removed because chemicals are still present
38
what is fast pain
◦ sharp, acute, pricking pain (needle puncture or cut) ◦ occurs rapidly after stimulus (.1 second) ◦ not felt in deeper tissues ◦ travels through large, fast-conducting nerve fibers
39
what is slow pain
◦ chronic, aching, burning or throbbing pain (eg. toothache) ◦ begins more slowly (1 sec) & increases in intensity ◦ in both superficial and deeper tissues ◦ travels through small, slow-conducting nerve fibers
40
what is superficial somatic pain
◦ Involves the stimulation of pain receptors in the skin
41
what is deep somatic pain
◦ Involves the stimulation of receptors in skeletal muscles, joints, and tendons
42
what is visceral pain
◦ Involves the stimulation of pain receptors in visceral organs; if stimulation is diffuse (involves large areas), visceral pain can be severe. Can be due to pressure, tears, ischemia, stretching, rubbing…
43
describe referred pain
Visceral pain is usually felt in specific skin or surface areas; skin area and organ are usually served by the same spinal cord segment e.g., heart attack can be felt in skin along left arm since both are supplied by spinal cord segment T1-T5
44
a) Shoulder pain while throwing a baseball b) Pain still present several minutes after stubbing your toe c) “Brain freeze” (sharp headache upon eating or drinking something cold) d) Pain down your leg from a pinched nerve in your back
c) “Brain freeze” (sharp headache upon eating or drinking something cold)
45
what are the different ways we can get pain relief
▪can block formation of chemicals that stimulate nociceptors (aspirin and ibuprofen) ▪can block conduction of nerve impulses along pain fibers (Novocaine = local anesthetic) ▪can lessen the perception of pain in the brain – pain is still sensed, but is not perceived as noxious (Morphine)
46
what is proprioception
Awareness of body position & movement ◦ walking or getting dressed without looking ◦ estimate weight of objects (so can adjust necessary force) Proprioceptors adapt only slightly
47
where is info about [roprioceptions sent to? What are the receptors?
Sensory information is continuously sent to cerebellum & cerebral cortex ◦ Receptors located in muscle, tendon, joint capsules & hair cells in the vestibular apparatus ◦ Receptors include 1. Muscle spindles, 2. Tendon organs (Golgi tendon organs), 3. Joint kinesthetic receptors
48
describe proprioceptors: muscle spindles
Muscle spindles are proprioceptors in skeletal muscles that monitor the length of muscle fibers (participate in stretch reflex) 39 1. Stretching stimulates muscle spindle EFFECTOR (same muscle) contracts and relieves the stretching 2. MOTOR NEURON excited SENSORY NEURON excited Within 3. INTEGRATING CENTER (spinal cord) Based on the input from muscle spindles, the brain also sets muscle tone
49
what are the different components of a muscle spindle
1. Sensory nerve endings wrap around 3-10 specialized muscle fibers (intrafusal fibers) 2. Alpha motor neurons innervate extrafusal muscle fibers to cause contraction of the muscle in response to stretching 3. Gamma motor neurons innervate intrafusal fibers to keep tension and maintain sensitivity of the muscle spindle even when muscle is contracted muscle spindle capsule (connective tissue)
50
how a muscle spindle works
1. Sensory neurons monitor the degree of stretching 2. Impulses are sent to the cerebral cortex (primary somatosensory area) for conscious perception of position and movement; impulses also sent to cerebellum for movement coordination 3. Motor neurons cause same muscle to contract in response to stretching (remember stretch reflex)
51
Muscle spindles a) Are found in tendons b) Are responsible for the stretch reflex c) When stretched, lead to relaxation of the muscle d) A and B e) A, B and C
b) are responsible for the stretch reflex
52
proprioceptors: tendon organs
Tendon organs are proprioceptors located at the junction of tendons and muscles (involved in tendon reflex)
53
what are the components of a tendon organ
Tendon fascicles (bundles of collagen fibers) laced with sensory nerve endings Capsule of connective tissue
54
how does a tendon organ work
1. Sensory nerve endings detect overstretching in the tendon (too much tension in muscle) 2. Impulses are sent to the cerebral cortex for conscious perception of position and movement; impulses also sent to cerebellum for movement coordination 3. Motor neuron is inhibited so muscle can relax (remember tendon reflex)
55
proprioceptors: joint kinesthetic receptors
Type II cutaneous mechanoreceptors (Ruffini corpuscles) ◦ found in joint capsule ◦ respond to pressure Small lamellated (Pacinian) corpuscles ◦ found in connective tissue around the joint ◦ respond to acceleration & deceleration of joints
56
what are the sensory, motor and integrative pathways
In general, pathways are: 1. Paired - located bilaterally 2. Axons are grouped based on body region innervated (recall nerves) 3. All tracts involve the Brain and the Spinal cord 4. The name of a pathway indicates its origin and its destination: e.g. spinothalamic e.g. vestibulospinal
57
sensory information ______ motor information ________ pathways are made of ______ and nuclei synapses are the site at which ________ of information will occur
ascends, descends, tracts, transfer / integration
58
true or flase: how many synapses a pathway has will depend on the type of pathway
How many synapses a pathway has will depend on the type of pathway ◦ Examples: ◦ Sensory pathways that end in the cortex have three neurons ◦ Sensory pathways that end in the cerebellum have two
59
what are somatic sensory pathways and what do they consist of?
Somatic sensory pathways relay information from somatic receptors to the primary somatosensory area in the cerebral cortex. The pathways consist of three neurons ◦ first-order neuron – from somatic receptor to spinal cord or brain stem ◦ second-order neuron – from spinal cord or brain stem to thalamus (opposite side because of decussation) ◦ third-order neuron – from thalamus to primary somatosensory area of cortex (on same side as thalamus)
60
61
In the posterior column medial lemniscus pathway, first-order neurons… a) synapse with second-order neurons in the thalamus b) synapse with third-order neurons in the thalamus c) synapse with second-order neurons in the pons d) synapse with second-order neurons in the medulla
D
62
Which sensation is not carried by the posterior column-medial lemniscus pathway? a) Proprioception b) Vibration c) Temperature d) Fine touch
c) temperature
63
describe the anterolateral (spinothalamic) pathway to the cortex
info is sent to primary somatosensory area of cortex second-order neurons and third-order neurons synapse in the thalamus first-ord3er neurons and second order neurons synapse in the posterior gray horn of the spinal cord second order-neurons deccusate to the other side of the spinal cord (at the bottom) receptors for pain, cold, warmth, tickle and itch
64
describe the trigemino-thalamic pathway to cortex (think how info would travel when the sun is on you face)
inform,ation is sent to the primary somatosensory area of cortex second-order neurons and third-order neurons synapse in the thalamus first-order neurons and second-order neurons synapse in the pons of medulla (in trigeminal nerve) receptors for touch, pressure, vibration, pain, cold, warmth, itch and tickle in the face, nasal cavity and teeth second order neurons deccusate to the other side of the brain stem
65
describe the sensory pathways to the cerebellum
(in the posterior spinocerebellar tract) axon collaterals of proprioceptive sensory neuros use the posterior and anterior spinocerebellar tracts to carry singlas into the cerebellum (not consciously perceived) (these are essential for posture, balance and coordination of skilled movements)
66
describe the two neuron pathway of the sensory pathways to the cerebellum (where are the receptors)
Receptor → 1 st order neuron → poterior grey horn → 2 nd order neuron Signal travels up to same side of body (no decussation) receptors are: muscle spindle and Golgi tendon organ
67
In sensory pathways to the cortex… a) the second-order neuron is always the one that decussates b) decussation always takes place in the medulla c) decussation always takes place in the thalamus d) A and B e) A, B and C
A
68
describe somatic motor pathways. What 2 motor neurons are always involved? what is the final common pathways
Always involve 2 motor neurons in series * Upper Motor Neuron (UMN): cell body in the CNS motor area (80% in cortex; 20% in brainstem) * Lower Motor Neuron (LMN): extends from the brain stem or spinal cord to innervate skeletal muscles FINAL COMMON PATHWAY * From brainstem through cranial nerves to innervate muscles of face and head * From spinal cord through spinal nerves to innervate muscles of limbs and trunk
69
where to lower motor neurons extend directly to
Lower Motor Neurons (LMN) extend directly from the CNS (where their cell bodies are) to skeletal muscles
70
for somatic motor pathways what does contol of body movement involve?
◦ Control of body movement involves: ◦ Motor portions of cerebral cortex ◦ Initiate & control precise movements Basal nuclei help establish muscle tone & integrate semi-voluntary automatic movements Cerebellum helps make movements smooth & helps maintain posture & balance
71
what are basal nuclei
The basal nuclei are 3 nuclei deep within each hemisphere: Caudate nucleus Putamen Globus pallidus
72
what are the 4 distinct neural circuits (somatic motor pathways - they always tell each other what to do) participate in control of movements by providing input to lower and upper motor neurons
1. Local circuit neurons are located close to lower motor neuron cell bodies in the brain stem and spinal cord. 2. Local circuit neurons and lower motor neurons receive input from upper motor neurons. 3. Neurons of the basal ganglia provide input to upper motor neurons. 4. Cerebellar neurons also control activity of upper motor neurons.
73
In somatic motor pathways… a) all pathways ultimately lead to the activation of the basal nuclei b) all pathways ultimately lead to the activation of the cerebellum c) all pathways ultimately lead to the activation of lower motor neurons
c) all pathways ultimately lead to the activation of lower motor neurons
74
where are local circuit neurons located and what do they do?
Local circuit neurons are located close to LMN cell bodies (in spinal cord or brain stem); they coordinate rhythmic activities (like alternating flexion and extension of lower limb muscles when walking). They receive input from sensory neurons as well as from higher centers in the brain.
75
Local circuit neurons… a) are neurons located in the basal nuclei b) are neurons located in the cerebral cortex c) are neurons located near lower motor neurons
c) are neurons located near lower motor neurons
76
describe upper motor neurons
UMN from cortex are involved in planning, initiating and directing movements. Most UMN synapse onto local circuit neurons, and some of them synapse directly onto LMN. They receive input from the basal nuclei and the cerebellum. UMN from brain stem regulate muscle tone, posture, orientation of head and body
77
Upper motor neurons… a) can descend from the brainstem or from the cerebral cortex b) can synapse onto local circuit neurons or onto lower motor neurons c) a and b
C
78
describe basal nuclei neurons
Basal nuclei neurons provide input to UMN (in cortex or brain stem); neural circuits interconnect the basal nuclei, the cerebral cortex and the brainstem. Help initiate and terminate movements, suppress unwanted movements and set normal level of muscle tone
79
The basal nuclei… a) influence upper motor neurons in the cortex or brain stem b) communicate directly with lower motor neurons c) a and b
a) influence upper motor neurons in the cortex or brain stem
80
what is the difference between the upper motor neurons from direct motor pathways and UMN from indirect motor pathways
UMN from direct motor pathways extend directly from the cerebral cortex to LMN UMN from indirect motor pathways extend from various nuclei of the brainstem and will use various tracts before they connect with LMN in both direct and indirect motor pathways, the basal nuclei and the cerebellum influences the UMN
81
direct motor pathways: describe the lateral corticospinal pathway
for movements of hands and feet (highly skilled movements) from cortex, through cerebral peduncles, 90% of UMN deccusate in the pyramids of medulla the lateral corticospinal tract forms in the lateral part of the SC UMN synapse either with local circuit neurons or with LMN in anterior gray horn of SC LMN exit through anterior root of spinal nerve
82
direct motor pathways: describe the anterior corticospinal pathway
The anterior corticospinal pathway is for movements of the trunk and proximal parts of limbs The remaining 10% of UMN that do NOT decussate in the pyramids use this tract Decussation occurs in the spinal cord, just before synapsing with local circuit neurons or LMN in anterior gray horn of SC
83
direct motor pathways: corticobulbar pathway
The corticobulbar pathway is for movements of skeletal muscles in head: eyes, tongue, neck, chewing, expression & speech from cortex to nuclei in brain stem, then cranial nerves: all but I, II and VIII (because these are sensory nerves) Some decussate, others don’t
84
85
Most motor neurons from direct motor pathways are dedicated to… a) Movements of hands and feet b) Movements of facial muscles c) Movements of trunk and proximal part of limbs d) a and b
a) movements of hands and feet
86
describe indirect pathways
All motor pathways other than the corticospinal and corticobulbar tracts Axons from UMNs descend from various nuclei in brainstem into 5 major tracts of spinal cord synapse w/ local circuit neurons or LMNs
87
describe the different basal nuclei connections
1. Basal nuclei influence movements through their effect on UMN ◦ Input from cortex (sensory, motor, association) and substantia nigra (midbrain) ◦ Output to cortex via thalamus ◦ Cortex to basal nuclei to thalamus to cortex – involved in initiating and terminating movements 2. Basal nuclei reduce muscle tone – damage causes a generalized increase in muscle tone 3. Basal nuclei suppress unwanted movements
88
describe how the cerebellum modulates movement
The cerebellum is active in both learning and performing rapid, coordinated, highly skilled movements and in maintaining proper posture and equilibrium. The four aspects of cerebellar function ◦ Monitoring intention for movement ◦ Monitoring actual movement ◦ Comparing intention with actual performance ◦ Sending out corrective feedback
89
90
91
what are the integrative functions of the cerebrum
SLEEP & WAKEFULNESS LEARNING AND MEMORY
92
sleep vs wakefullness
Sleep - a state of altered consciousness or partial unconsciousness from which an individual can be aroused by different stimuli During wakefulness, the cerebral cortex is very active During most stages of sleep, less activity is seen in the cerebral cortex
93
what does the reticular activating system (RAS) do?
Sleep and wakefulness are controlled by the reticular activating system (RAS), found in the reticular formation RAS has numerous connections to the cortex; Arousal involves increased activity in the RAS, which increases activity in the cortex Many types of inputs can activate the RAS: pain, light, noise, muscle activity, touch (but not smell)
94
describe sleep
During sleep, activity in the RAS is very low ◦ Adenosine is a sleep-inducing chemical in the brain that inhibits activity in RAS ◦ caffeine binds to adenosine receptors, thereby preventing adenosine from binding and inducing sleep Normal sleep consists of two types: ◦ non-rapid eye movement sleep (NREM) ◦ inactive brain, active body ◦ rapid eye movement sleep (REM) ◦ active brain, inactive body
95
describe REM sleep
Most dreams occur during REM sleep 3-5 episodes of REM in a 7-8 hour sleep, increasing in length (first ~10min, last ~50min) ◦ total REM sleep = 90 to 120 minutes Total REM & dreaming time decreases with age ◦ ~80% REM in newborns ◦ ~50% REM in infants ◦ ~35% REM in 2yo ◦ ~25% REM in adults 95 * Neuronal activity & oxygen use is highest in REM sleep (higher than during intense mental or physical activity!) * Motor neurons are inhibited (except for breathing and eye movements) = paralysis of skeletal muscles * REM thought to be important for proper brain development and function
96
learning vs memory
Learning is the ability to acquire new information or skills through instruction or experience Memory is the process by which that information is stored and retrieved For an experience to become part of memory, it must produce persistent structural and functional changes that represent the experience in the brain ◦ The capability for change with learning is called PLASTICITY
97
what are the different types of memory
Declarative memory vs Procedural memory Short-term memory lasts only seconds or minutes and is the ability to recall bits of information; changes in synapses Long-term memory lasts from hours, days to years and is related; anatomical and biochemical changes at synapses ◦ Long-term memory for information that can be verbalized is stored in cerebral cortex ◦ Long-term memory for motor functions stored in basal ganglia, cerebellum and cortex
98
what are the different stages of sleep (not super important)
Stage 1 ◦ person is drifting off with eyes closed (first few minutes) Stage 2 ◦ person becomes increasingly harder to awaken Stage 3 ◦ relaxed, deep sleep, body temperature & BP drop, reflexes and muscle tone are intact ◦ bed-wetting & sleep walking occur in this phase Note: stages 3 used to be separated into stages 3 and 4
99
Sleepwalking occurs in which stage of nonrapid eye movement (NREM) sleep? a) stage 1 b) stage 2 c) stage 3 d) None of these – it occurs during REM sleep
C
100
when do you get the greatest amount of deep sleep
Cycles of N1 → N2 → N3 → N2 → REM. There is a greater amount of deep sleep (stage N3) earlier in the night, while the proportion of REM sleep increases later in the night, in the cycles before natural awakening