anat lab 16 : urinary Flashcards

1
Q

list the structures and how they work together

A

The urinary system consists of two kidneys, two ureters, one urinary bladder and one
urethra. As the kidneys filter blood plasma to produce urine, they maintain the electrolyte,
acid-base and fluid balances in the blood. The kidneys produce the enzyme renin, two
hormones, calcitriol and erythropoietin, and can synthesize glucose. Lastly the kidneys
excrete wastes by forming urine. Urine contains the byproducts of metabolic reactions
(urea, ammonia, billirubin, creatinine, and uric acid), drugs and environmental toxins. The
ureters, bladder and urethra act as transport and storage areas.

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2
Q
A
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3
Q

describe the anatomy of the kidneys

A

The kidneys are located just above the waist, posterior to the peritoneum of the abdominal
cavity (retroperitoneal). The medial face of each kidney contains a notch, the hilum of
the kidney, through which blood vessels, nerves, lymphatic vessels, and the ureters enter
and exit.

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4
Q

description and function capsule

A

The fibrous capsule of the urinary system is a thin, tough layer of connective tissue that surrounds each kidney.

Description:
- It is a smooth, transparent membrane that tightly adheres to the kidney’s surface.
- Made of dense irregular connective tissue, it provides strength and flexibility.

Function:
1. Protection: Shields the kidney from physical trauma and infections.
2. Structural Support: Helps maintain the kidney’s shape and integrity.
3. Barrier: Prevents the spread of infections to and from the kidney.

This capsule plays a vital role in safeguarding the kidney’s delicate internal structures.

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5
Q

hilum of the kidney description and function

A

The hilum of the kidney is a concave, slit-like area located on the medial side of each kidney.

Description:
- It is the entry and exit point for structures associated with the kidney.
- Includes the renal artery, renal vein, ureter, lymphatic vessels, and nerves.
- Leads into a space within the kidney called the renal sinus.

Function:
1. Pathway for Blood Vessels: The renal artery brings oxygenated blood into the kidney, and the renal vein carries filtered blood out.
2. Urine Transport: The ureter exits the kidney at the hilum, carrying urine to the bladder.
3. Lymphatic and Nervous Supply: The hilum provides a route for lymphatic drainage and nerve innervation to and from the kidney.

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6
Q

renal cortex description and function

A

The renal cortex is the outer layer of the kidney, located just beneath the fibrous capsule and surrounding the inner medulla.

Description:
It has a granular appearance due to the presence of millions of tiny structures called nephrons, specifically the glomeruli and convoluted tubules.
It is lighter in color compared to the medulla.
Function:
1. Filtration: Houses the glomeruli, where blood filtration begins, removing waste products and excess substances.
2. Reabsorption and Secretion: Contains the proximal and distal convoluted tubules, which reabsorb essential nutrients and secrete waste products into the forming urine.
3. Hormone Production: Plays a role in producing erythropoietin (EPO), which stimulates red blood cell production.

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7
Q

renal medulla description and function

A

The renal medulla is the innermost part of the kidney, located beneath the renal cortex.

Description:
It is made up of renal pyramids, which are cone-shaped structures.
The apex of each pyramid (the renal papilla) points toward the renal pelvis.
It has a striped appearance due to parallel arrangements of tubules and blood vessels.
Function:
1. Concentration of Urine: Contains the loops of Henle and collecting ducts, which concentrate urine by reabsorbing water and salts.
2. ransport of Urine: Directs urine from the nephrons into the renal pelvis via the renal papillae.
3. Salt and Water Regulation: Plays a critical role in maintaining the body’s salt and water balance through the countercurrent mechanism in the loops of Henle.
The renal medulla is vital for producing concentrated urine and regulating the body’s fluid balance.

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8
Q

renal pyramids description and function

A

The renal pyramids are triangular-shaped structures located within the renal medulla of the kidney.

Description:
- Each kidney contains several renal pyramids.
- They are striped in appearance due to parallel nephrons, loops of Henle, and collecting ducts.
- The apex of each pyramid, called the renal papilla, points toward the renal pelvis.

Function:
1. Urine Collection: The collecting ducts within the pyramids collect urine from the nephrons and funnel it toward the renal papilla.
2. Urine Transport: Urine flows from the renal papillae into the minor calyces, eventually leading to the renal pelvis and ureter.
3. Water and Salt Regulation: The loops of Henle within the pyramids play a key role in concentrating urine by reabsorbing water and salts.

The renal pyramids are essential for urine production, concentration, and transportation.

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9
Q

renal papilla description and function

A

The renal papilla is the tip or apex of a renal pyramid located in the renal medulla of the kidney.

Description:
- It is the narrow, rounded end of the renal pyramid.
- It projects into a small cup-shaped structure called the minor calyx.
- Contains openings of the collecting ducts, where urine exits the pyramids.

Function:
1. Urine Drainage: Acts as the passage through which urine flows from the collecting ducts into the minor calyx.
2. Transport to the Renal Pelvis: Facilitates the movement of urine from the kidney tissue into the renal pelvis, which leads to the ureter.

The renal papilla is a critical structure for efficiently channeling urine out of the kidney toward the urinary tract.

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10
Q

renal columns

A

The renal columns are areas of cortical tissue that extend down between the renal pyramids in the kidney.

Description:
- Located in the renal medulla, but composed of the same tissue as the renal cortex.
- They appear as lighter, column-like structures separating the darker renal pyramids.

Function:
1. Support for Blood Vessels: Provide pathways for blood vessels (interlobar arteries and veins) to reach deeper parts of the kidney.
2. Structural Support: Help anchor and separate the renal pyramids, maintaining the structural integrity of the kidney.
3. Housing Nephrons: Contain portions of the nephron structures involved in filtering and transporting urine.

The renal columns are essential for facilitating blood flow within the kidney and providing structural organization.

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11
Q

minor and major calyx description and function

A

Minor Calyx
Description:
- The minor calyx is a small, cup-shaped structure located at the tip of each renal papilla.
- Each kidney has several minor calyces, which surround the renal papillae to collect urine.

Function:
1. Urine Collection: Receives urine from the renal papillae of the renal pyramids.
2. Urine Transport: Channels the collected urine into the major calyces.

Major Calyx
Description:
- The major calyx is a larger, funnel-like structure formed by the convergence of two or more minor calyces.
- Each kidney typically has 2-3 major calyces.

Function:
1. Urine Collection: Collects urine from the minor calyces.
2. Urine Transport: Directs urine into the renal pelvis, the next structure leading to the ureter.

Both structures are crucial for moving urine from the kidney tissue to the ureter while maintaining an organized flow.

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12
Q

renal pelvis description and function

A

Renal Pelvis

Description:
- The renal pelvis is a funnel-shaped structure located in the central part of the kidney.
- It is formed by the convergence of the major calyces.
- The renal pelvis narrows at its lower end to become the ureter, which transports urine to the bladder.

Function:
1. Urine Collection: Serves as a reservoir for urine, collecting it from the major calyces.
2. Urine Transport: Channels urine into the ureter for delivery to the urinary bladder.

The renal pelvis is essential for efficiently moving urine out of the kidney and into the urinary system for excretion.

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13
Q

ureter description and function

A

Ureter

Description:
- The ureter is a pair of muscular, tube-like structures (one for each kidney) that extend from the renal pelvis of the kidney to the urinary bladder.
- Each ureter is approximately 25–30 cm (10–12 inches) long.
- Its walls are made of smooth muscle, lined with a mucous membrane, and capable of peristalsis (wave-like contractions).

Function:
1. Urine Transport: Carries urine from the renal pelvis to the urinary bladder.
2. Prevention of Backflow: A one-way valve at the bladder-ureter junction prevents urine from flowing back into the ureter.
3. Regulation: Peristaltic movements ensure a steady flow of urine, regardless of body position or gravity.

The ureters are vital for connecting the kidneys to the bladder, ensuring the smooth and controlled movement of urine for storage and eventual excretion.

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14
Q

renal artery vs renal vein description and function

A

Renal Artery
- Description: A thick, muscular blood vessel that branches from the aorta.
- Function: Carries oxygen-rich blood from the heart to the kidneys. This blood also contains waste and nutrients for filtration.

Renal Vein
- Description: A thinner, wider blood vessel that connects the kidney to the inferior vena cava.
- Function: Carries oxygen-poor and filtered blood (after waste removal) from the kidneys back to the heart.

Key Difference:
- Renal artery brings blood to the kidneys for filtration.
- Renal vein takes filtered blood away from the kidneys.

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15
Q
A
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16
Q

what are nephrons and what do they consist of?

A

Nephrons are the basic functional unit of the kidneys. A nephron consists of a renal
corpuscle and a renal tubule.

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17
Q

describe the renal corpuscle

A

The renal corpuscle includes a glomerulus inside a double-walled glomerular (Bowman’s)
capsule. The glomerulus is a network of blood capillaries. As blood passes through the
capillaries, blood pressure forces materials, the filtrate, into the capsular space
surrounding the glomerulus, where it passes to the renal tubule.

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18
Q

what are the steps in urine formation

A

As blood passes through the
capillaries, blood pressure forces materials, the filtrate, into the capsular space
surrounding the glomerulus, where it passes to the renal tubule. This is the first step of
urine formation, called glomerular filtration.
The second and third steps, tubular reabsorption and tubular secretion, take place in the
renal tubules and collecting ducts. A renal tubule has three main sections: the proximal
convoluted tubule, a nephron loop (Loop of Henle), and a distal convoluted tubule.
Several distal convoluted tubules empty into one collecting duct. Collecting ducts unite to
form papillary ducts, which drain into the minor calyces.

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19
Q

what happens in the renal tubules

A

In the renal tubules, water and many useful solutes are returned to the blood by tubular
reabsorption. Wastes, drugs and excess ions are secreted into the fluid in the renal tubules
by tubular secretion for excretion.

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20
Q

describe where the afferent glomerular arterioles lead to?

A

One afferent glomerular arteriole enters each glomerular capsule and divides into a
tangled network of capillaries comprising the glomerulus. The capillaries reunite to form the
efferent glomerular arteriole as they exit the glomerular capsule. Efferent arterioles
divide to form the peritubular capillaries or vasa recta around the renal tubules. These
capillaries play an important role in tubular reabsorption and tubular secretion.

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21
Q

description and function of the nephron

A

Description:
- A tiny filter in the kidney.
- Each kidney has about 1 million nephrons.
- It has two main parts:
1. Filter (Renal Corpuscle): Filters blood to remove waste.
2. Tube (Renal Tubule): Adjusts water and nutrients, making urine.
Function:
The nephron cleans your blood and balances your body’s fluids in four steps:

  1. Filtration: Filters out waste, water, and small substances from the blood.
  2. Reabsorption: Returns useful things like water and nutrients to the blood.
  3. Secretion: Adds extra waste and unwanted stuff to the urine.
  4. Excretion: Sends the urine to the bladder to be removed from the body.

It’s like a tiny water filter that keeps your blood clean!

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22
Q

renal corpuscle:
glomerulus

capsular space
glomerular capsule

description and function

A

1. Glomerulus
- Description: A ball of tiny blood capillaries inside the renal corpuscle.
- Function: Acts as a filter. It allows water, small molecules, and waste to leave the blood while keeping large proteins and blood cells inside.

2. Capsular Space
- Description: The small gap between the glomerulus and the glomerular capsule.
- Function: Collects the filtered fluid (called filtrate) from the glomerulus. This is the starting point for urine formation.

3. Glomerular Capsule (Bowman’s Capsule)
- Description: A cup-shaped structure surrounding the glomerulus.
- Function: Protects the glomerulus and directs the filtrate into the tubules for further processing.

Summary:
- Glomerulus filters blood.
- Capsular space collects the filtered fluid.
- Glomerular capsule protects and guides the filtrate to the next step in the nephron.

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23
Q

function and description of renal corpuscle

A

where blood plasma is filtered

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24
Q

renal tubule function and associated structures

A

The renal tubule is a part of the kidney that collects filtered blood products and produces urine. The

renal tubule’s functions include:
Reabsorbing vital substances: The renal tubule absorbs water, electrolytes, amino acids, and ions.
Eliminating excess substances: The renal tubule removes excess substances from the body through urine

Proximal convoluted tubule (PCT)
The first segment of the renal tubule, located in the renal cortex. The PCT reabsorbs and secretes water and solutes.

Loop of Henle
A structure in the renal tubule that helps with water conservation and reabsorbing nutrients.

Descending limb
Highly permeable to water but impermeable to ions. The descending limb’s thin segment is the primary site of water reabsorption.

Ascending limb
Impermeable to water but highly permeable to ions. The ascending limb’s thin segment moves sodium and chloride out of the tubule, while the thick segment moves sodium, potassium, and chloride out.

distal convoluted tubule The distal convoluted tubule (DCT) is a short nephron segment, interposed between the macula densa and collecting duct. Even though it is short, it plays a key role in regulating extracellular fluid volume and electrolyte homeostasis.

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25
Q

juxtaglomerular apparatus and macula densa

A

The Juxtaglomerular Apparatus helps control blood pressure and fluid balance.
The Macula Densa acts like a sensor for salt levels in the urine.

macula densa is found inside the juxtaglomerular apparatus

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26
Q

collecting duct description and function

A

Collecting Duct

Description:
A long tube in the nephron that connects to many nephrons.
It runs through the kidney’s inner parts (medulla) and ends at the renal pelvis.
Shared by multiple nephrons.
Function:
1. Final Adjustment:
Regulates the amount of water and electrolytes in urine.
Controlled by hormones like ADH (antidiuretic hormone) and aldosterone to either save water or release more.
2. Urine Collection:
Collects urine from the nephron and sends it to the renal pelvis for transport to the bladder.

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27
Q

papillary duct description and function

A

The papillary duct is the final part of the collecting duct system.
It is located in the renal papilla, where it opens into the minor calyx of the kidney.
Formed by the merging of multiple collecting ducts.
Function:
Transports Urine: Delivers the final urine from the collecting ducts into the minor calyx, which leads to the renal pelvis and then to the bladder.

28
Q

afferent glomerular arteriole vs efferent glomerular arteriole

A

A small blood vessel that carries blood into the glomerulus (the filtering unit in the kidney).
It is larger in diameter compared to the efferent arteriole, which helps maintain filtration pressure.
Function:
Blood Supply: Brings oxygen-rich blood containing waste and nutrients to the glomerulus for filtration.
Pressure Regulation: Its wider size ensures high pressure in the glomerulus, which is crucial for filtering blood efficiently.

efferent: A small blood vessel that carries blood away from the glomerulus after filtration.
It is narrower in diameter than the afferent arteriole, which helps maintain pressure in the glomerulus.
Function:
Blood Flow Regulation: Controls blood leaving the glomerulus, maintaining the pressure needed for efficient filtration.
Blood Redistribution: Sends blood to the capillaries surrounding the nephron (peritubular capillaries and vasa recta) for further exchange of nutrients, water, and waste.

efferent is like an exit pipe

29
Q

peritubular capillaries/
vasa recta

A

They differ in location, function, and association with nephrons:
Location
Peritubular capillaries surround the renal tubules in the cortex, while vasa recta are located in the medulla and surround the loop of Henle.
Function
Peritubular capillaries are involved in resorption, while vasa recta are involved in filtration. Peritubular capillaries reabsorb substances like amino acids, minerals, and glucose, while vasa recta carry water and excess salt reabsorbed from the nephron loop and thick ascending limb.
Association with nephrons
Peritubular capillaries are associated with both cortical and juxtamedullary nephrons, while vasa recta are only associated with juxtamedullary nephrons.
Origin
Vasa recta are extensions of peritubular capillaries that branch off the efferent arterioles of juxtamedullary nephrons

30
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A
31
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A
32
Q

describe the histology of the kidneys

A

beginning with
the cortex: blood vessels (simple squamous) forming the glomerulus are visible as a small
ball, surrounded by a narrow white region, the capsular space. The parietal layer of the
glomerular capsule visible just outside the capsular space is also simple squamous
epithelium.
The majority of the cortex around the glomerular capsule consists of proximal and distal
convoluted tubules, which are formed by cuboidal epithelium. Proximal convoluted tubules
have a brush border of microvilli on their apical surface, which may or may not be visible,
depending on the quality of the section and the stain.
Moving toward the middle region of a pyramid, many tubules can be seen, composed of
cuboidal or squamous epithelium. You do not need to identify the squamous epithelium of
the nephron loop on this slide.
Continue toward the papillary region of the pyramid. Where the papillary ducts empty into
the minor calyx the epithelium is columnar in shape.
Continue scanning to the right to find the ureter, opening off the renal pelvis. The ureter is
lined by transitional epithelium.

33
Q
A
34
Q

describe glomerular filtration (structure)

A

The filtration membrane is formed by the glomerular endothelial cells of the
glomerular capillaries, the basement membrane of the glomerulus (basal lamina), and
the podocytes that form the visceral layer of the glomerular capsule. Glomerular
endothelial cells have large fenestrations (pores) that are quite leaky. Podocytes have
thousands of processes, called pedicels, which wrap around the glomerular capillaries,
forming a leaky barrier. Spaces between the pedicels are called filtration slits; a thin
membrane, the slit membrane, extends across each filtration slit.

For a substance to be filtered out of the blood passing through the glomerulus, it must be
small enough to pass through the glomerular endothelium, the basement membrane (basal
lamina) underlying the endothelial cells, and squeeze through the slit membrane into the
capsular space.

35
Q

list three substances besides glucose and water which are small enough to pass through the slit membrane

A

ionic salts, sodium, vitamins, ions, amino acids

36
Q

what is the only determinant of which molecules enter the filtrate (slit membrane)?

A

Because size is the only determinant of what which molecules enter the filtrate, both wastes
and essential solutes are removed. Any water and solutes still needed by the body are
reabsorbed into the blood from the renal tubules.

37
Q

Which layer of the filtration membrane keeps big proteins in the plasma?

A

basement membrane - this membrane is also made up of three layers, and is fused to the endothelial layer. Its job is to prevent plasma proteins from being filtered out of the bloodstream. Epithelium - this layer consists of specialized cells called podocytes.

38
Q

Which layer keeps albumin in the plasma?

A

Glomerular filtration barrier
A series of layers that separates the blood from the urinary space. The layers include:
Endothelium: The first layer, made up of cells with fenestrations that allow small solutes and plasma proteins to pass through.
Basement membrane: The second layer, a gel-like membrane with tiny pores that prevents plasma proteins from passing through.
Podocytes: The outermost layer, made up of specialized cells that wrap around the capillaries and leave slits between them. A thin diaphragm between the slits acts as a final filtration barrier.

39
Q

Which layer keeps RBCs and platelets in the plasma?

A

Glomerular basement membrane: A thick, dense central layer with thinner inner and outer layers.

40
Q
A
41
Q

what is filtration? describe it

A

Filtration is a passive process in which water and solutes are removed from a
solution as the solution flows across a membrane. Filtration takes place across
capillaries and in the kidneys, where the volume of material that is moving across a
plasma membrane is too large for osmosis or diffusion to transport. In filtration, the
pressure exerted by the blood will force any particle small enough to pass through
the membrane’s pores; the concentration of the solute or solvent does not have any
effect.

42
Q

describe what juxtaglomerular cells do in response to decreased blood flow and blood volume or due to sympathetic stimulation

A

In response to decreased blood flow and blood volume, or due to sympathetic stimulation,
juxtaglomerular cells secrete renin into the blood. Renin starts an enzymatic cascade
that converts angiotensinogen into angiotensin I. Angiotensin I is converted into the
hormone angiotensin II in the lungs

43
Q

what are the effects of Angiotensin II

A
  • it causes vasoconstriction of afferent arterioles, resulting in a decrease in the
    glomerular filtration rate. - it causes the proximal convoluted tubule to reabsorb more sodium and chloride and
    to secrete potassium ions. The reabsorption of sodium and chloride leads to
    reabsorption of water by osmosis. - it stimulates the secretion of aldosterone by the suprarenal cortex.
    Aldosterone causes the collecting ducts to reabsorb more sodium and chloride,
    and to secrete more potassium ions.
44
Q

describe the regulation and secretion of the antidiuretic hormone

A

Review the regulation and secretion of antidiuretic hormone from the Endocrine System:
dehydration or a decrease in blood volume stimulates the osmoreceptors in the
hypothalamus, which causes the neurosecretory cells to produce antidiuretic hormone

ADH has three target tissues: - the kidneys reabsorb more water, decreasing urine production. - secretions by sweat glands decreases, reducing water loss by perspiration. - smooth muscles in the arterioles contract, decreasing the diameter of the vessels,
causing an increase in blood pressure.

45
Q

describe the ureters

A

The ureters conduct urine, by gravity and peristalsis, from the renal pelvis to the urinary
bladder. The ureters, like the kidneys, are retroperitoneal. The mucous membrane of the
ureters is urothelium (transitional epithelium), with goblet cells providing mucus as
protection against the acidic urine. On the torso, follow the ureters inferiorly from the kidneys
to the urinary bladder.
Review the ureter slide from BIOL 1190 to see a ring of urothelium surrounded by a thick
layer of longitudinal and circular smooth muscles

46
Q

describe the urinary bladder

A

The urinary bladder is a hollow, muscular organ found in the pelvic cavity. It is also lined
with urothelium (transitional epithelium). Mucosal folds (rugae) allow for the expansion of
the urinary bladder to accommodate urine. The floor of the urinary bladder has a flat
triangular area called the trigone, which contains the two ureteral openings and the
internal urethral orifice.

47
Q

what is this

A

urothelium of the urinary bladder

48
Q

what is this

A

transitional epithelium fo the ereter

49
Q

describe the urethra

A

The urethra transports urine from the urinary bladder to the body exterior. Near the
external urethral orifice the epithelium of the urethra changes to non-keratinized
stratified squamous epithelium. In males, the urethra has a dual function: it is a urine
conduit, and it provides a passageway for semen ejaculation.

50
Q

description and function of the urinary bladder

A

. This triangle-shaped, hollow organ is located in the lower abdomen. It is held in place by ligaments that are attached to other organs and the pelvic bones. The bladder’s walls relax and expand to store urine, and contract and flatten to empty urine through the urethra.

51
Q

trigone description and function

A

The trigone is triangular in shape and stabilizes the attachment of the ureters to the bladder, and the otherwise mobile bladder to the pelvic fascia.

52
Q

ureteral openings

A

The ureteral opening is the slit-like point where the ureter enters the bladder

53
Q

internal urethral orifice

A

The internal urethral orifice is the opening where the urethra connects to the urinary bladder. It’s located at the bottom of the bladder, in the middle of the triangular area called the trigone.

54
Q

urethra

A

The urethra is the tube that lets urine leave your bladder and your body

55
Q

external urethral orifice vs internal urethral orifice

A

The internal urethral sphincter is composed of smooth muscle and regulates involuntary control of urinary flow from the bladder to the urethra, while the external urethral sphincter provides voluntary regulation.The internal urethral sphincter in men also functions to prevent the retrograde flow of semen into the bladder during ejaculation. The average length of the male urethra is about 22 cm, and in women, just 4 cm.

56
Q

mucosal folds (rugae)

A

The rugae and transitional epithelium allow the bladder to expand as it fills. The second layer in the walls is the submucosa, which supports the mucous membrane.

57
Q
A
58
Q

what is urinalysis

A

A urinalysis is a simple test to determine if urine formation is normal or abnormal. It
analyzes the volume of urine produced as well as its physical, chemical and microscopic
composition, and the levels of some metabolic wastes.

59
Q

what are the normal characteristic of urine

A
60
Q

what are the normal constituents of urine

A

Normal chemical constituents of urine include water, urea, creatinine, uric acid, and
many electrolytes.

61
Q

name abnormal constituents in urine and their causes

A
62
Q

What causes urine to have a higher specific gravity than distilled water?

A

Urine is denser than pure water because it contains excreted solutes. Therefore the urine specific gravity is always greater than 1.000. Specific gravity is affected by the number of solute particles in solution as well as their molecular weight.

63
Q

name 5 normal solutes found in urine

A

The main solutes found in urine are urea, sodium, potassium, chloride, phosphate, uric acid, and sulfate:

64
Q

List five abnormal components of urine.

A

Abnormal constituents of urine are sugar, proteins, blood, bile salts, bile pigments and ketone bodies.

65
Q

What is hemodialysis?

A

Hemodialysis is a treatment to filter wastes and water from your blood, as your kidneys did when they were healthy. (kidneys are no longer healthy in individuals who need it

66
Q

What causes crystals of salt in urine to solidify into renal calculi (kidney stones)?

A

Under certain conditions, substances normally dissolved in urine, such as calcium, oxalate and phosphate, become too concentrated and can separate out as crystals. A kidney stone develops when these crystals attach to one another, accumulating into a small mass, or stone.

67
Q

Name a condition that is a result of the build-up of bilirubin in the skin and sclera, and
usually indicates liver disease? H

A

Jaundice, also known as hyperbilirubinemia, is defined as a yellow discoloration of the body tissue resulting from the accumulation of excess bilirubin.