CH. 16 Respiratory System: Pulmonary Ventilation Flashcards

1
Q

What is internal respiration?

- What process does it utilize?

A

how cells use oxygen

- oxidative phosphorylation

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2
Q

What is external respiration?

A

how do we get oxygen to blood

- occurs through exchanges between blood (i.e lungs and body tissue)

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3
Q

What are the 3 air passages of the head and neck?

A
  1. nasal cavities
  2. oral cavity
  3. pharynx
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4
Q

What are the 3 airways from the pharynx to lungs?

A
  1. larynx
  2. conducting zone
  3. respiratory zone
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5
Q

What are the 7 components of the conducting zone composed of?

A
  1. larynx
    - glottis
    - epiglottis
  2. trachea
  3. bronchi
  4. secondary bronchi
  5. tertiary bronchi
  6. bronchioles
  7. terminal bronchioles
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6
Q

What are 3 functions of the conducting zone?

A
  1. air passageway
  2. increases air temperature to body temperature
  3. humidifies air as there is a lot of water vapor in the lungs
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7
Q

What is the epithelium of the conducting zone comprised of?

A
  1. goblet cells: secrete mucus
  2. ciliated cells: move particles toward mouth
  3. mucus escalator
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8
Q

What is the function of the respiratory zone?

A
  1. exchange of gases between air and blood

2. mechanism of action: diffusion

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9
Q

What are the four structures of the respiratory zone?

A
  1. respiratory bronchioles
  2. alveolar ducts
  3. alveoli
  4. alveolar sacs
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10
Q

What is the epithelium of the respiratory zone comprised of?

A

a respiratory membrane

  • epithelial cell layer of alveoli
  • endothelial cell layer of capillaries
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11
Q

Where is the site of gas exchange in the respiratory tract?

A

alveoli

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12
Q

How do alveoli have a rich blood supply?

A

capillaries form sheet over alveoli

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13
Q

What are the differences between Type I and Type II alveolar cells?

A

Type I alveolar: make up wall of alveoli

Type II alveolar: secrete surfactant

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14
Q

How do type II alveoli maintain shape of alveoli when stretched?

A

surfactant is released which disrupts hydrogen bonds between water molecules

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15
Q

What structures make up the chest wall?

A
  1. rib cage
  2. sternum
  3. thoracic vertebrae
  4. muscles: internal and external intercostals, diaphragm
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16
Q

What gradient drives the flow of air?

A

pressure gradient

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17
Q

What does the pressure need to be for inspiration and expiration?

A

Inspiration: pressure in lungs less than atmospheric pressure

Expiration: pressure in lungs greater than atmospheric pressure

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18
Q

What is the transpulmonary pressure?

A

Intra-alveolar pressure - Intrapleural pressure

-distending pressure across the lung wall

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19
Q

What is the intra-alveolar pressure? and when is it negative/positive in relation to inspiration/expiration?

A

pressure of air in alveoli; what moves air in and out of lungs

  • during inspiration = negative
  • during expiration = positive
20
Q

What is the intra-alveolar pressure? and when is it negative/positive in relation to inspiration/expiration?

A

pressure of air in alveoli; what moves air in and out of lungs

  • during inspiration = negative
  • during expiration = positive
21
Q

What is the intrapleural pressure? and when is it negative/positive?

A

pressure inside pleural sacs

- always negative under normal conditions due to elasticity of lungs and chest wall

22
Q

What is the transpulmonary pressure? and when is it positive/negative?

A

distending pressure across the lung wall

- always positive

23
Q

How does Boyle’s law explain how air moves in and out of the lungs?

A

as pressure increase, volume decrease; air would passively move into lungs

24
Q

What factors determine intra-alveolar pressure?

A
  1. quantity of air in alveoli

2. volume of alveoli

25
What occurs when lungs expand?
1. Intra-alveolar pressure decreases | 2. pressure gradient drives air into lungs
26
What occurs as lungs recoil?
Intra-alveolar pressure increases | - pressure gradient drives air out of lungs
27
What inspiratory muscles increase the volume of the thoracic cavity?
diaphragm and external intercostals
28
What expiratory muscles decrease volume of thoracic cavity?
internal intercostals and abdominal muscles
29
What are the ways in which expiration occur?
1. normally a passive process | 2. active expiration requires expiratory muscles
30
What is lung compliance? and what does a larger lung compliance allow?
ease with which lungs can be stretched - easier to inspire - smaller change in transpulmonary pressure needed to bring in a given volume of air
31
What factors affect lung compliance?
1. elasticity: more elastic -> less compliant | 2, surface tension of lungs: greater tension -> less compliant
32
What needs to be present to overcome surface tension?
surfactant secreted from type II cells
33
Why is airway resistance relatively low?
pressure gradient is needed for air flow
34
What factors affect airway resistance?
1. passive forces 2. contractile activity of smooth muscle 3. mucus secretion
35
What are two passive forces that affect airway resistance?
1. changes in transpulmonary pressure during respiratory cycle 2. tractive forces
36
What enables sympathetic control of bronchiole radius?
norinepinephrine
37
What enables parasympathetic control of bronchiole radius?
acetylcholine
38
What is the intrinsic control of bronchiole radius comprised of?
1. Histamine: bronchoconstriction | 2. CO2: bronchodilation
39
What are two pathological states that increase airway resistance?
1. asthma | 2. chronic obstructive pulmonary diseases
40
What are obstructive pulmonary diseases?
associated with increased airway resistance
41
What are restrictive pulmonary diseases?
more difficult for lungs to expand
42
What is a forced vital capacity?
maximum-volume inhalation followed by exhalation as fast as possible
43
What is forced expiratory volume?
percentage of FVC that can be exhaled within a certain time frame
44
What is a peak expiratory flow rate?
maximum rate at which a person can exhale
45
What is minute ventilation?
total volume of air entering and leaving the respiratory system each minute
46
What is the anatomical dead space?
air in conducting zone that does not participate in gas exchange
47
What is alveolar ventilation?
volume of air reaching the gas exchange areas per minute