Ceutics 4 Test 1 Flashcards
Impact of Particle Size
Dissolution Rate Suspendability of Suspensions Uniformity of Dose Penetrability of particles for inhalation Lack of grittiness for dermatologicals
Sieve Analysis
Particles passed through series of sieves, proportions determined
Andersen Cascade Impactor
Particle size determination for inhalation
What impacts particle flow?
Size, Shape, Porosity
What is Tapped and Bulk density for?
Determine flow and compressibility, determine storage needs
Pulverization
Comminution using a solvent that can be easily removed
Levigation
Trituration while moistened with a liquid that powder is insoluble in
Factors of Blending
Size
Shape
Density
Electrostatic Forces
Dentifrices
for teeth
Insufflations
for body cavities
Hygroscopic
absorbs moisture from air
Deliquescent
absorbs moisture from air to extent they liquefy
Efflorescent
Liberates water of hydration when relative humidity is low
Eutectic
mixture with melting point less than room temp, liquefy when in close prolonged contact
Efferescent
Acid base reaction, makes CO2
Advantages of Capsules
Masks tastes/appearnce Identifiable Flexible Easy to swallow Uniformity Easy to mass produce Stable
Disadvantages of Capsules
Easily tampered
Sensitivyt to humidity
Unsuitable for aqueous liquids
Unsuitable for highly soluble ionic slats
Diluents
Lactose Microcrystalline cellulose Starch Sucrose Mannitol Dibasic Calcium Phosphate
Disintegrants
Pregelatinized Starch
Croscarmellose
Sodium Starch Glycolate
Lubricants
Fumed Silicon Dioxide Magnesium Stearate Calcium Stearate Stearic Acid Talc
Surfactant
Sodium Lauryl Sulfate
Advantages of Tablets
Accurate dosage Absence of Alcohol Concentration Variability Elegance Patient Acceptance Convenience Tamper Resistant
Disadvantages of Tablets
Swallowing
Difficult to extemporaneously prepare
Compression
oxygen/moisture-sensitivie
Binders
Acacia Alginic Acid Carboxymethylcellulose Gelatin Liquid Glucose Methylcellulose Povidone Pregelatinized Starch
Antiadherents
Talc
Magnesium Stearate
