Ceutics 3 Test 2 Flashcards
1
Q
Excipients: Buffers
A
Citric Acid
Phosphate Acid
Histidine
2
Q
Excipients: Ionic Strength
A
Sodium Chloride
Potassium Chloride
Glycine
3
Q
Excipients: Prevent Physical Degradation
A
Sucrose Trehalose Mannitol Arginine Histadine Metal Binding (Ca,Cu,Mg,Zn)
4
Q
Excipients: Non-Ionic Surfactants
A
Polysorbate 80
Polysorbate 20
5
Q
Excipients: Oxygen Scavangers
A
Methonine Cysteine Ascorbic Acid Sodium Sulfite Thiglycerol
6
Q
Excipients: Metal Chelators
A
EDTA
Citric Acid
7
Q
Excipients: Preservatives
A
Benzyl Alcohol
Phenol
Cresol
8
Q
Amino Acids susceptible to deamidation
A
Asparagine
Glutamine
9
Q
Impacts Protein Structure
A
pH Ionic Strength Temperature Light Oxygen Shear Contact Surfaces Excipients
10
Q
Rapid Acting Insulin
A
Insulin Lispro (Humalog) Insulin Aspart (Novalog)
11
Q
Short Acting Insulin
A
Insulin Glargine
Insulin Detemir
12
Q
Intermediate Acting Insulin
A
Isophane Insulin (NPH) Insulin-Zinc (Lente)
13
Q
Long Acting Insulin
A
Insulin-Zinc Extended (Ultralente)
Insulin Glargine
Isophane 70/30, 50/500.75
NPL/Lispro 75/25
14
Q
-omab
A
Murine (mice)
15
Q
-ximab
A
Chimeric
