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Pharmaceutics 1 > Ceutics 3 Test 1 > Flashcards

Ceutics 3 Test 1 Flashcards

1
Q

Max amounts of Cationic Surface-Active Compounds

A

0.01%

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2
Q

Max amounts of Chlorobutanol, Cresol, Phenol

A

0.5%

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3
Q

Max amounts of Sulfer Dioxide, Sulfite, Bisulfite, Metabisulfite

A

0.2%

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4
Q

Methods of Sterilization

A 
Steam
Dry Heat
Filtration
Gas
Ionizing Radiation
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5
Q

Absorption slow to fast

A

Oleaginous then Aqueous

Intradermal -> SubQ -> IM ->IV

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6
Q

Solutes permeable to RBC membrane

A 
Urea
NH4Cl
Alcohol
Boric Acid
Glycerin
Propylene Glycol
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7
Q

Water Soluble Anti-Oxidants

A 
Sodium Sulfite
Sodium Metabisulfite
Potasium Metabisulfite
Cysteine
Ascorbic Acid
Sodium Ascorbate
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8
Q

Non-Aqueous Anti-Oxidants

A

Butylated Hydroxyanisole
Butylated Hydroxytoluene
Alpha Tocopherol

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9
Q

Anti-Microbials

A 
Benzyl Alcohol
Phenol
Parabens
Chlorobutanol
Benzalkonium Chloride (eye,nose,otic)
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10
Q

Pyrogen Inactivation

A

Physical (detergent or WFI rinse)
Heat (250 C for 30 mins)
Chemical (HCl & NaOH, H2O2 or KMnO4)

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11
Q

Depyrogenation

A 
Distillation (WFI)
Ion Exchange (endotoxins are negatively charged)
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12
Q

Sterility Testing

A

Direct Inoculation

Membrane Filtration

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13
Q

Endotoxin Testing

A

Rabbit Test

Limulus Amoebocyte Lysate (LAL) test

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14
Q

Labe Requirements

A 
Name & Amount of all ingrediets
Total Volume
Route of Admin.
Storage
BUD
Other Info
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15
Q

Mix order for TPN or TNA

A

Lipids
Amino Acids
Dextrosse

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16
Q

Causes of Precipitation

A 
Solvent Polarity Change
pH Change
Temp. Change
Formation of Insoluble Salts
Anions and Cations Complex
17
Q

Stable Calcium Salts

A

Gluconate and Acetate

18
Q

Filter size for TNA of lipids and non-lipid suspensions

A
  1. 2 micron for lipid

0. 2 micron for non-lipid

19
Q

Low Risk

A

BUD: 48 hrs room temp, 14 Days refrig., 45 Days frozen

2 entries per container, 3 products

20
Q

Medium Risk

A

BUD: 30 hrs room temp, 9 Days refrig., 45 Days frozen

Complex Compounding

21
Q

High Risk

A

BUD: 24 hrs room temp, 3 Days refrig., 45 Days frozen

Non-sterile anything, must be sterilized before admin.

22
Q

Immediate Use

A 
BUD: 1 hr from start of compounding
Non-hazardous drugs, 3 products, 2 entries
Emergency situations (ER, combat, cardiac arrest)
23
Q

Endotoxin Limit Formula

A

EL = K/M
5.0 EU/Kg/Hr or 0.2 EU/Kg/Hr if intrathecal
K : Threshold pathogen dose
M : Max Dose

Pharmaceutics 1 (6 decks)

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