Cerebellum Flashcards
Cerebellum
integrates massive sensory and other inputs from the brain and spinal cord
cerebellum participate in
motor planning
cerebellum relationship with LMNs
no direct connection
cerebellum is found in
posterior cranial fossa
cerebellum is covered superiorly by
tentorium cerebelli = infratentorial
cerebellum is posterior to what structures
4th ventricle
pons
upper medulla
cerebellum is connected to the post aspect of the brainstem by
sup, mid, and inf cerebellar peduncles
cerebellum form what structure
roof of 4th ventricle
deepest fissure of cerebellum
primary fissure
what fissure separates anterior and middle (POST) lobe
primary fissure
fissure that separates the middle lobe from flocculonodular lobe
uvulonodular fissure (posterolateral fissure)
along the margin of the cerebellum that separates the superior from inferior surfaces
horizontal fissure
3 main lobes of cerebellum
anterior lobe, middle (post) lobe, fiocculonodular lobe
on the superior surface and separated from middle (post) lobe by the primary fissure
anterior lobe
largest lobe
middle (posterior) lobe
lobe between the primary and uvulonodular fissure
middle (post lobe)
herniate through the foramen magnum in cases of increased intercranial pressure
cerebellar tonsil
cerebellar tonsil herniation cause death via compression of
medullary respiratory centers
3 functional subdivisions
vermis, flocculonodular lobe, cerebellar hemispheres
influences movement of long axis of the body (neck, shoulder, thorax, abdomen,a nd hips)
vermis
balance and vestibulo-ocular reflex
flocculonodular lobe
zones of cerebellar hemisphere
intermediate and lateral zone
immediately lateral to the vermis; control muscles of distal part of limbs
intermediate zone
planning of sequential movements of entire body; conscious assessment of movement occurs
lateral zone
functions of each functional division of the cerebellum
lateral hemispheres - motor planning for extremities
intermediate hemispheres - distal limb coordination
Vermis - proximal limb and trunk coordination
flocculonodular lobe - balance and vestibulo-occular reflexes
gray and white of cerebellum
outer gray (cortex), inner white
small ridges that run from medial to lateral surface of the cerebellum (leaves)
folia
3 layers (outer to inner)
molecular layer
purkinje cell layer
granular layer
molecular layer contains what cells
stellate (outer)
basket (inner)
purkinje cell layer contains what type of neuron
large golgi type 1 neuron
flask-shaped, arranged in a single layer
purkinje cell layer
describe branches of purkinje cell layer
primary, secondary are smooth
subsequent are covered by short thick dendritic spines
purkinje cell layer terminates by synapsing with
intracerebellar nuclei
small cells with densely staining nuclei and scanty cytoplasm
granular cell
each granular cell gives rise to how many dendrites
4-5
axons of granular cell pass through molecular layer and bifurcates at
T junction
branches running parallel to the long axis of the folium
run at right angles to the dendritic processes of the purkinje cells
synapse with spinous process of dendrites of purkinje cells
parallel fibers
dendrites ramify in molecular layer and axons terminate with dendrites of granular cells
golgi cells
intracerebellar nuclei consist of (lat to med)
Dont Eat Greasy Food
Dentate
Emboliform
Globose
Fastigial
composed of large, multipolar neurons with branching dendrites
intracerebellar nuclei
receive collateral fibers of cerebellar inputs on their way to the
cerebellar cortex
all outputs from cerebellum are relayed by
cerebellar nuclei
largest intracerebellar nuclei
dentate nucleus
interior of dentate nucleus is filled with white matter efferents that leave the nucleus to form
superior cerebellar peduncle
dentate nucleus receive projections from
lateral cerebellar hemisphere
dentate nucleus is active when
before voluntary movement
ovoid shape and medial to the dentate
emboliform nucleus
consists of one or more rounded cell groups medial to the emboliform nucleus
globose
emboliform and globose is collectively known as
interposed nuclei
interposed nuclei (emboliform and globose) receive input from
intermediate part of cerebellar hemisphere
interposed nuclei (emboliform and globose) is active when
during and in relation to movement
intracerebellar nuclei that is close to the roof of 4th ventricle
fastigial nucleus
fastigial nucleus receive input from
vermis (more) and flocculonodular lobe
white matter in vermis and cerebellar hemisphere
small amount in vermise, increase in cerebellar hemisphere
group of white matter that doesnt leave cerebellum and connects different regions within the organ
intrinsic
greater group of white matter which proceed to cerebellar cortext
afferent
output group of white matter
efferent
efferent group starts off as
axons of purkinje
cerebellar peduncles
superior cerebellar peduncle = brachium conjunctivum
Middle = brachium pontis
Inferior = resitiform body
cerebellar peduncles decussates at the level of
inferior colliculi
cerebellar peduncle inputs what
superior - output from cerebellum
middle and inferior - input
2 kinds of synaptic inputs to cerebellum
climbing fibers
mossy fibers
synaptic inputs to cerebellum are excitatory to
purkinje fibers
terminal fibers of olivocerebellar tract
climbing fibers
1 climbing fiber:
10 purkinje cells
1 purkinje cell:
1 climbing fiber
arise from numerous origins
terminal fibers of all other cerebellar afferent tracts
mossy fibers
1 mossy fiber:
thousand of purkinje cells through granule cells
other cells of cerebellar cortex (inhibitory interneurons)
stellate
basket
golgi
center of a functional unit of cerebellar cortex
purkinje cells
stellate cells terminate on
purkinje cell dendrites
basket cells terminate on
purkinje cell body
receive excitatory inputs from the granule cell paralell fibers in the molecular layer
shorten the durtion of excitatory inputs to the granule cell
golgi cell
excited by synaptive inputs from granule cell then give rise to processes that run in rostro caudal direction, perpendicular to the parallel fibers
lateral inhibition of adjacent purkinje cells and narrow the spatial extent of excitatory inputs to purkinje cells
stellate and basket
In intracerebellar nuclear mechanisms, afferents come from
inhibitory axons of purkinje cells
excitatory aoxns from climbinga nd mossy fibers passing to the cortex
cerebellar cortical NT
Glutamate - excitatory; climbing and mossy fibers to dendrites of purkinje cells
Norepinephrine and serotonin- modify the action of glutamate on purkinje cells
rough somatotopic organization, with ipsi body represented in both anterior and posterior lobes
cerebellar input pathways
cerebellar input pathways is carried by
mossy fibers and climbing fibers (olivocerebellar fibers)
pathways from cerebral cortex
corticopontocerebellar
cerebro-olivocerebellar
cerebroreticulocerebellar
cerebral cortex control what
voluntary movement
monitor and adjust muscle activity
pathway that gives rise to mossy fiberd
corticopontocerebellar pathway
spinocerebellar fibers from spinal cord
anterior (ventral) spinocerebellar tract
posterior (dorsal)
cuneocerebellar
rostral spinocerebellar
functions of spinocerebellar tracts
Anterior spinocerebellar
- convey info from MS, Tendon organs, and joint receptors of UE and LE
Posterior
- trunk and LE
cuneocerebellar
- UE and neck
Vestibulocerebellar fibers
- info about position of head and body in space
- orienting the eyes during movement
main outflow from cerebellum
axons from cerebellar nuclei