Cerebellar Lecture Flashcards

1
Q

Cerebellum is located: to teh 4th ventrilce

A

posterior

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2
Q

What 3 pairs of arteries supply the cerebellum:

A

SCA- Superior cerebellar artery (from basilar)
AICA- Anterior Inferior Cerebellar Artery from basilar
PICA from veretebral

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3
Q

name of the convolutions on the cerebellum

A

folia

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4
Q

Anterior lobe lies:

A

anterior to the primary fissure

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5
Q

Posterior lobe lies:

A

posterior to primary fissure

includes cerebellar tonsils (medial inferior part)

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6
Q

Cerebellar tonsils lie on:

A

posterior lobe

– tonsilar herniation is of clincal significance

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7
Q

Parts of floculonodular lobe:
1:
2:

A
1 nodule (partis)
2 flocculi
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8
Q

The nodule and flocculi are separated from posterior lobe by

A

posterolateral fissure

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9
Q

The flocculonodular lobe forms the:

A

vestibulocerebellum: control of equilibrium, balance, and eye movements

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10
Q

vermis along midline

and function

A

vermis: part of spinocerebellum

CONTROLs axial and proximal limb movements

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11
Q

Longitudinal subdivision:: Intemediate zone of cerebral hemi
-function

A

part of spinocerebellum

Controls distal limb movments

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12
Q

Lateral zone of cerebellar hemissphere:

A

part of cerebrocerebellum

PLanning and initiaition movments

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13
Q

Excitatory afferent from contralateral inferior olivary nuclues that synapse directy onto PKJ

A

Climbing fibers

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14
Q

Excitatory afferent from all other sources (besides olives) that synapse with granule cesll – which synapse with PKJ

A

Mossy fibers

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15
Q

Ihnibitory output neurons of the cerebellar cortex

A

PKJ

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16
Q

Granule cells are excitatory/inhibitory

A

excitatory

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17
Q

Baskey cells :

A

ihibitory interneurons

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18
Q

stelalate cells are:

A

inhibitory interneurons

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19
Q

What makes up the MOlecular layer of cerebellum

(5) parts

A

Dendrites of PKJ
Parallel fibres from axons of granule cells (excitatory)
Climbing fibers from contralateral infereior olivary nucleus (exicatory)
Stellate (inhibitory)
Basket (inhibitory)

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20
Q

each parallel fiber activates up to_____ PKJ

each climbing fibers innervates _______PKJ but each PKJ can only have 1 climbing giver

A

500
1-10
1

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21
Q

What goes on in the PKJ cell layer

-where does it send output to

A

PKJ cells are inhibitory (GABA) and output goes only to deep cerebellar nuclei

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22
Q

Components of granule cell layer: (3)

A

Granule cells~ excitatory
Golgi cells~ inhibitory
Mossy fibers (exicatory) and synpase with lots of granule cells

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23
Q

Where does the white matter lie?

A

beneath the granule cell layer

24
Q

The major output neurons of the cerebellum as a whole

A

Deep cerebeller nuclei

25
Q

DCN recive excitatory input from:

A

climbing and mossy fibers~ collaterals of afferents to cerebellar cortex

26
Q

DCN receive inhibitory input from

A

PJK cells of cerebellar cotex

27
Q

OUT put from DCN is :

A

Excitatory

28
Q

Three sets of nuclei that make up DCN

A

Dentate: largest/lateral from lateral zone
Interposed nuclei: intermediate/from intermediate zone
Fastigial:medial/ from vermis

29
Q

Circuit of Clmibing fibers

A

Excite PKJ–>which inihbit DNC–>which excite output to other regions

30
Q

Circuit of Mossy fibers

A

Excite granues–>which form parallels–>excite PKJ–> inbit DCN–> excite output to other regions

31
Q

Circuit of inhibitory interneurons:

A

baskets + stellate –> inihbit PKJ and

Golgi cells in granule layer –> inhibit the granules

32
Q

Functions of Vestibulocerebellum: Floccunodular lobe and inferior vermis functions

A

balance and equilibruim while moving, controls eye mvmts, coordinates head/eye mvmnts

33
Q

Afferent inputs to Flocculonodular lobe

A
Vestibular labytinth (isp semicircular canals) direcltly
vestibular labrything-->Vestibular nuclei 
Visual centers (LGN, supeior colliculus and visual cortex)-->pontineds
34
Q

Vestibular nuclei gives rise to:

A
Vestibulospinal tract (axial musculature)
Medial longitudinal fasiculus: head/eye movments
35
Q

Spinorcerebellum (vermis and intermediate zone) fnxs

A

Vermis controls axial/proximal msls
Intermediate zone: control of distal limb mscls
*both for ongoing execution of movements

36
Q

Spinocerebellum afferent inputs:

Ispilateral sp cd and lower medulla project via:

A

Dosal spinocerebellar tract

Cuenocerebellar tract

37
Q

Spinocerebellum afferent inputs:

Contralateral inferior olivary nucleus project via:

A

Olivocerebellar tract

38
Q

Spinocerebellum afferent inputs:

All three tracts travel w/in the _______ to reach the spinocerebellm

A

Inferior Cerebellar peduncle

39
Q

The ispilateral spinal cord crosses the midline to contralateral _______ upwards to the Superior Cerebelar peduncle then recrosses the midline to the _______

A

Ventral spinocerebellar tract (it’s contralatera)
(still contralateral in the Superior cereellar peduncle
recrosses to IPSILATERL SPINOCERebellar lob

40
Q

Spinocerebellum Major Efferents:

Cerebellar cortex–> DCN– to the

A

SCP

41
Q

How does vermis get to Axial and proximal muscles?

A

Sends efferents from vermis–>DCN–> brain stem–> medial descending system–> control over axial and proximal mslces

42
Q

How does vermis get to motor and premotor cortex?

A

Sends efferents from vermis –> DCN–> Thalamus–> motor/premotor cortex for voluntary movements

43
Q

How do afferents from Contralatearl cortex get to teh Lateral part of the cerebrocerebellum (part for planning and mental rehersal)

A

Contralateral cotex –> Corticopontine tract–> pontine nuclei –> through middle peduncle to the cerebellum

44
Q

Cerebrocerebellum (lateral efferents) major efferents:

A

Starts lateral cerebrocerebellum–>
to DCN—> (contralateral)
Red nucleus midrain –>
Thalamux –> Motor and Premotor Cortex

45
Q

What two paths do the lateral efferents from the cerebrocerebellum take once they reach motor cortex?

A
Motor cortex-->
Corticospinal --> corsses isp
--> to spinal cord   OR
Motor cortex -->
corticopontine-->
Pons (this path stays contralateral) and back up to CDN or lateral zone
46
Q

Monoaminergic afferent to cerebellum: ______fibers from Raphe nuclei

A

Serotninergic

plays modulatory role

47
Q

Monoaminergic afferents to cerebellum: _______ fibers from Locus cerueleus

A

Nonadrenergic

plays modulatory role

48
Q

General fnx of cerebellum

A
  • balance and eye movement
  • regulates posture by indirecly modulating outpout of major descending systems
  • compare intection and actual movement
49
Q

The Cerebellum recives info about plans for movement and premotor cortex via:

A

corticocerebellar tract

50
Q

The cerebellum monitors integration of descending and peripheral infor regarding movment in spinal cord via

A

ventral spinal cerebellar tract

51
Q

Cerebellum recieves feedback from sensory via

A

dorsal spinocerebellar trat during movement

52
Q

Cerebellum projects to motor centers that send fibers to the spinal cord __________tract to adjust output of motor system

A

dentororubothralmic tract

53
Q

Lesion of cerebelllum will

A

disrupt coordinated limb and eye movements, impair balance, reduce tone

54
Q

Cerebellar lesions usually cause _______motor signs

A

ipsilateral

55
Q

Major signs of cerebellum dysfunction

A

ataxia, hypotonia, intentiaonal tremor, dysdiadochockinesa, dysmetria, nystagmus, titubation

56
Q

Damage to cerebellum can result in:

A

impaired motor learning