Cellular Signals Flashcards
Autocrine
target cell is the same cell as the one that releases the signalling molecule
Paracrine
target cell is a nearby cell to the one that releases the signalling molecule
Endocrine
target cell is a distant cell compared to the one that releases the signalling molecule, and must travel in the bloodstream
Exocrine
target cell is outside the organism
Animal Hormones
Source: endocrine glands in the body, e.g. cells, organs and glands
Three types of animal hormones:
- Peptide and protein (hydrophilic – only have receptors on the cell membrane)
- Amino acid derived (hydrophilic – receptors on the cell membrane)
- Steroid/lipid derived – lipophilic (hydrophobic – receptors found inside the cell)
Plant Hormones
Source: plant cells that are undergoing growth, ripening, abscission etc.
- Act as signalling molecules that target various cells (those undergoing growth, ripening, abscission etc.) and produce specific effects
- Produced by individual cells in growing regions of the plant (e.g. roots, leaves)
- Usually transported in the phloem
Cytokines
Small protein molecules that act as messengers between cells of the immune system.
Acts on the cells in the immune system with specific receptors.
Source: Immune system
Mode of transmission: autocrine, paracrine, endocrine
Pheromones
Chemical signalling molecule released by one animal that carries a signal to the cells of a second member of the same species.
Secreted by an animal into external environments and externally regulates others’ behaviour.
Source: exocrine glands of animals of the same species
Mode of transmission: Exocrine
Neurotransmitters
Carries signals from one neuron to the next, and transmits nerve impulses from neurons to muscle cells stimulating their contraction.
Function of Neurotransmitters
To either continue or stop a signal from happening (excitatory or inhibitory)
Signal Reception
- Reception of a signalling molecule from a cell’s external environment
- When signalling molecules reach their target cells, they bind to a specific receptor
- Each type of receptor protein binds to one signalling molecule with a specific shape
- Cell receptors are located on the plasma membrane of the specific target cell (due to polar and hydrophilic signalling molecules being unable to cross the lipid bilayer), in some cases the receptors are in the cytosol or the nucleus of the target cell
- hydrophobic/hydrophilic nature of signalling molecules determines the location of specific receptor where signal is received
Ligand
chemical signalling molecule that binds to the receptor on a target cell
Signal cascade
: Multiple cell signals that amplify initial signal by activation of secondary messengers by G-proteins
Hydrophobic signalling molecules
the signalling molecule will pass through the plasma membrane and bind to a receptor either in the cytosol or in the nucleus
Hydrophilic Signalling molecules
cannot diffuse across the plasma membrane, so they bind to a membrane-bound receptor. This causes a shape change in the receptor, which activates a second messenger. The second messenger causes a chain reaction within the cell