Cell Signlaing Quiz Flashcards
Types of Local signaling
Paracrine signaling and synaptic signaling
Signals that act locally between cells that are close together; move thru diffusion through extracellular matrix—discharging molecule
Paracrine signaling
Neurotransmitter molecule released into synapse—stimulates target cell.
Synaptic signaling
Specialized endocrine cells secrete hormones into body fluids (mainly blood)
Endocrine signaling
What type of molecules are secreted by signaling cells
Messenger molecules
What are the three stages of signal transduction pathway
- Reception
- Transduction
- Response
Chemical signal binds to a cellular protein at cell surface
Reception
Binding changes protein, stimulates changes like signal transduction pathway
Transduction
Transduced signal activates cell activity
Response
What is a ligand
Molecule that binds to another molecule, often larger.
A ligand causes the receptor protein to…
Change shape
Enzyme that transfers phosphate groups from ATP to a protein
Protein kinase
What is responsible for phosphorylation, occurs in cascades
Protein kinase
What do protein phosphates do
Catalyze the removal of phosphate groups from proteins making inactive and reusable
Used for intracelular signal transduction, activates protein kinase
Cyclic AMP
What is synthesized from ATP by G proteins and that are attached receptors and become released when receptor is actived
Cyclic AMP
What is the 2nd messenger cAMP made from…
ATP by adenylyl cyclase
Cyclic AMP is inactivated by,,,
Phosphodesterase, enzyme that converts it to AMP
Activation of specific gene by a growth factor
Nuclear responses
The stimulation of glycogen breakdown by epinephrine
Cytoplasmic response
Cellular processes altered upon receipt of a signal
Nuclear and cytoplasmic
What happens nuclear responses?
Protein stimulates transcription of specific genes; mRNA directs synthesis of protein in cytoplasm
What is the result of cytoplasmic response
Glucose 1-phosphate
Ion channel receptors
Contains a region that acts as a gate when receptor changes shape—when signaling molecule binds as a ligand
Acceptor tyrosine kinases
Enzymes that are capable of adding P to tyrosine on target proteins; at cellular membrane, activated by ligand
G protein coupled receptor
Cell surface trans membrane receptor that works with G protein; transmits signal from extracellular substances
Reasons cell division is important for unicellular and multiveullar organisms
Uni: only way they can reproduce
Multi: need cell division to grow and replace dead or damaged cells
Why a cell division important to an adult organism after it is fully developed
Cells in the skin and gut our continuously renewed.
Heal wounds
Role of growth factors
Cells divide in response to specific molecular signals
What is differentiation
Cells stop dividing in response to specialize in structure and function