Cell Motility Flashcards
What are cilia and flagella built from?
Microtubules - dynein??
What is the major functional structure in cilia and flagella?
The axoneme
The bending of what structure in cilia and flagella results in their movement?
The axoneme
Structure of axoneme
9 outer pairs, pair in centre. Radial spokes
Structure of basal bodies
9 triplet microtubule array, derived from centriole
What are the outer doublets of the axoneme made up of?
Complete (A) fibres and incomplete (B) fibres
Which motor protein is present on the outer doublets?
Dynein
What do dynein arms do?
Generate flexion when dynein hydrolyses ATP and changes shape
In isolation, what does dynein produce?
Microtubule sliding but in flagellum causes bending
Why does dyneim cause microtubule bending in flagellum?
Due to linking proteins in flagellum
What does the inner dynein arm affect?
Shape of wave
What does the outer dynein arm affect?
Power
What do basal bodies do?
Act to firmly root cilia at cell surface
What are the 2 types of actin-based movement?
- Muscle movement - moves whole organism
2. Non-muscle movement - moves individual cells
What is the contractile unit of muscles? How do they influence the appearance of skeletal muscle?
- Sarcomere - Give skeletal muscles their striated appearance