cell mediated responses - t cells Flashcards
lymphocytes
white blood cells involved in specific immune response
made in bone marrow
T cells mature in thymus
step 1
once pathogen is destroyed by phagocytosis, the antigens are positioned on cell surface
they are now called antigen presenting cells
step 2
helper t cell have receptors on surface which bind to antigens on antigen presenting cell
step 3
once attached it activates helper t cell to divide by mitosis to replicate and make large numbers of clones
step 4
cloned helper t cells differentiate into different cells
some remain as helper t cells that activate b lymphocytes
some stimulate macrophages to preform more phagocytosis
some become memory cells for shaped antigens
some become cytotoxic t cells (killer t cells)
cell mediated t cells
they will only respond to antigens which are present of cells and are not antigens detached from cells of body fluid
antigen presenting cells
any cell that presents non self antigens on its surface
infected body cells
macrophage after phagocytosis will present the antigen on the surfacce
cells of transplanted organs will have different shaped antigens on the surface compared to self cells
cancer cells - abnormal shaped self cell antigens
Cytotoxic cells
Destroys abnormal or infected cells
Releases proteins which embeds in cell surface membrane and makes pores so any substances can enter and exit cells
Most common in viral infections
Body cells are sacrificed to prevent viral replication