Cell Mediated Response

Question 1

What cells does the cell mediated response involve

Answer 1

T cells

Question 2

Where are the cells for cell mediated response made and where are they matured

Answer 2

Made in the bone marrow
Mature in the thymus

Question 3

What is an ‘ APC ‘

Answer 3

Any cell presenting a non-self cell antigen on its surface

Question 4

List examples of ‘ APC’s ‘

Answer 4

Macrophage with pathogen antigen on surface
Viral antigens on cell
Cells from a transplanted organ
Cancer/Tumour cells

Question 5

Why is it called a ‘ Cell Mediated response ‘

Answer 5

T cells only respond to antigens on the surface of cells, doesn’t respond to antigens detached from cells

Question 6

Describe the steps in the ‘ Cell mediated response ‘

Answer 6

1. APC present
2. Receptor cells on T helper cell bind to antigens on the APC
3. Once binded, T helper cells stimulated
4. Replication via mitosis

Question 7

How do T helper cells replicate

Answer 7

By mitosis

Question 8

What different cells can T helper cells differentiate into

Answer 8

T helper cells - stimulating B cells
Memory cells for antigen
Killer T cells
Macrophages stimulating phagocytosis

Question 9

How do Cytotoxic T cells work

Answer 9

Release perforin
Making pores in cell
Allowing substances to enter and leave cell
Causing cell death

Question 10

What do killer T cells release causing cell death

Answer 10

Perforin