Cell Mediated Immunity

Question 1

2 classes of T cell receptor

Answer 1

an alpha:beta T cell receptor

a gamma:delta T cell receptor

Question 2

T cell progenitors are made in the ____, and then go to ____ tissues for maturation

Question 3

T cell progenitor comes from the bone marrow into the___ of the thymus.

it proliferates and becomes a ___ ___ cell

antigen presntation by cortical epithelial cells transforms it into a ___ ___ cell with CD4+ and CD8+

it then goes into the ____ where antigen presentation is mediated by medullary epithelial or dendritic cells, transforming it into a ___ ____ cell (either CD4+ or CD8+)

it then graduates into the periphery.

Answer 3

T cell progenitor comes from the bone marrow into the CORTEX of the thymus.

it proliferates and becomes a DOUBLE NEGATICE cell

antigen presntation by cortical epithelial cells transforms it into a DOUBLE POSITIVE cell with CD4+ and CD8+

it then goes into the MEDULLA where antigen presentation is mediated by medullary epithelial or dendritic cells, transforming it into a SINGLE POSITIVE cell (either CD4+ or CD8+)

it then graduates into the periphery.

Question 4

multiple combinations of __ ___ and __ regions of a T cell provides it with creating diversity

Question 5

B cells recognize antigens that are ___, ____ ___ or ___ ___. T cells recognize antigens that are __ ___

Answer 5

b cells recognize carbohydrate, AA, and nucleic acid antigens

T cells recognize antigens that are amino acid peptides.

Question 6

which antigen presenting cells interact with T cells?

Question 7

antigen presenting cells (ex/ b cells) internalize the antigen and break it. down into proteins, loading it onto a _____ complex, aka an ___ in humans, and present to the ___ or ____ cells

Question 8

Class _ MHC are on ___ cells and bind to _____ T cells.

Class __ MHC are on ___ cells and bind to ___T cells.

Question 9

MHC genes are found on which chromosome

Answer 9

chromosome 6

Question 10

How do B cells get activated by T cells?

Answer 10

1. ag binds ab on B cell
2. b cell presents Ag in MHCII
3. T cell with matching TCR binds B cell via MHCII and antigen
4. T cell secretes cytokines to tell B cell to activate and make Abs

Question 11

what is costimulation

Answer 11

at the same time as MHC on the antigen prsenting cell is communicating with the t cells, there are other receptors on the APC that are communicating with the T cell, exerting different effects.

Question 12

CD4+ Th1 subtype is involved in:

Question 13

CD4+ T cell subtype TH2 is involved in:

Answer 13

produces IL4 to stimulate the production of IgE. involved in allergy and parasite response. IL5 activate the eosinophils to help fight the parasites.

Th2 cytokines also activate macrophages to help with tissue repair.

Question 14

CD4+ t cell subtype Th17 is involved in:

Answer 14

secreting IL17, IL22, recruites neutrophils and monocytes. creates inflammation.

there is a role in autoimmune disease. Too much Th17 Cd4+ cells = rheumatoid arthritis.

Question 15

Treg CD4+ subype is involved in

Question 16

central tolerance

Question 17

Peripheral tolerance

Question 18

CD8+ cytotoxic T cells are primarily repsonsible for killing tumor cells. Why does the immune system still fail and cause cancer?

Answer 18

1. tumors may look like self antigens
2. tumor doesn’t express MHC classI so doesn’t display Ag
3. Tumor secretes immunosuppressive proteins.

Question 19

Question 20

failure of tolerance results in ____, failure of immune surveillance rseults in ___-

Answer 20

autoimmunity, maligancy