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Molecular Biology Exam 2 > Cell Junctions, Adehsion Molecules And EC Matrix > Flashcards

Cell Junctions, Adehsion Molecules And EC Matrix Flashcards

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1
Q

Characteristics of Selectins

A
  • Ca+ Dependent Adhesion molecule
  • Bind to Carbs
  • Belong to the Lectin group
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2
Q

Types of Junctions

A
  1. Zonula
    - Travel around CIRCUMFERENCE of the cell
    - Link neighboring cells to the central cell
  2. Macula
    - Associated with HEMI/DESMOSOMES
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3
Q

Another name for Zonula Occludens

A

Tight Junctions

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4
Q

Components of the Basement Membrane

A
  1. Basal Lamina
    - Produced by Epithelium
  2. Reticular Lamina
    - Produced by Connective tissue
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5
Q

Sub Categories of Cadherins. Where are they found?

A
  1. E-Cad
    - Found in EPITHELIAL tissue (Most common)
  2. N-Cad
    - Found in NERVE cells
  3. P-Cad
    - Found in Placenta
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6
Q

What are Hemidesmosomes?

A

Anchoring Jxns that anchor the Basal Domain of the Epithelial cell to Basal Lamina

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7
Q

Composition of Gap Jxns

A
  • Composed of ConnexOns

- 1 ConnexOn = 6 ConnexIn, forming a hexagonal structure

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8
Q

EC Integrins bind to what?

A

Molecules in the ECM

  • Such ad Fibronectin and Laminin
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9
Q

Role of Integrins in Hemi-Desmosomes

A

Integrins link the basal domains of cells to the EC Matrix via IC Tonofilaments

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10
Q

Characteristics of Non-Classical Cadherins

A
  • Found in DESMOSOMES
  • Include
    1. Desmocollins
    2. Desmogleins
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11
Q

Purpose of Catenins

A

Serve as a Major interface b/w the Cadherins that hold ADJACENT cells together AND the ACTIN cytoskeleton of those cells

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12
Q

What 2 groups are Cell Adhesion Molecules divided into?

A
  1. Calcium Dependent

2. Calcium INDEPENDENT

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13
Q

Main Fxn of Selectins

A

Involved in the movement of Leukocytes from blood to tissue

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14
Q

What are Integrins? Where do they bind?

A
  • Glycoproteins that are involved in Cell EC Matrix Interactions
  • They bind to BOTH EC Matrix and the CYTOSKELETON
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15
Q

Fxn of the basement Membrane

A

Separates the Epithelial layer from its Connective tissue

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16
Q

Diff B/w Focal Adhesion and Desmosomes

A

FA
- IC attachment is ACTIN

Desmosome
- IC attachment is KERATIN
(Tonofilaments)

17
Q

Sub Categories of SELECTINS. What are they associated with?

A
  1. P-Sel
    - Associated with Platelets
  2. E-Sel
    - Associated w/ activated Endothelial cells
  3. L-Sel
    - Associated with Leukocytes
18
Q

Zonula Adherens are associated with ____ while the Macula Adherens are associated with the _____.

A
  1. Actin Microfilaments

2. Intermediate Filaments

19
Q

Members of the IG Superfamily

A
  1. N-CAM
    - Neural Cell Adhesion Molecules
    - Mediate Both Homophilic and Heterophiic Interactions
  2. I-CAM
    - IC Cell Adhesion Molecule
    - Facilitates the trans Endothelial migration of Leukocytes
20
Q

Characteristics of Classical Cadherins

A
  • Major component in Ca2+ mediated ADHEREN Jxn

- Typically form a CIS and TRANS Homophilic dimers

21
Q

Fxns of Gap Jxns

A
  • Close when [Ca2+] are High

- Responsible for Chemical and Electrical coupling

22
Q

IG Superfamily Characteristics

A

Possess an EC Segment w/ 1+ Folded domains

  • Characteristic of IG
23
Q

Categories of Junctional Complexes

A
  1. Adherens
  2. Occludens
  3. Gap Jxns
24
Q

Fxn of Occludens

A
  • Establish an IMPERMEABLE Barrier b/w adjacent cells

- Prevent Paracellular Transport

25
Q

Ca2+ Independent molecules

A
  • Integrins

- Immunoglobulin Superfamily Molecules

26
Q

Consequence of loss of E-Cadherins

A

Associated with Invasive behavior of TUMOR Cells

27
Q

Characteristics of Laminin

A
  • The MAJOR component of the Basal Lamina

- Has binding sites for Integrins, Type 4 collagen and PTG

28
Q

Fxn of Tight Jxns

A

Provide a Barrier against the Paracellular Transport pathway

29
Q

Integrins interact it’s with what sequence of Fibronectin

A

RGD

  • > Arg-Gly-Asp
30
Q

Properties of Type 4 Collagen

A

Predominant collagen in the BASEMENT MEMBRANE

Noncellular layer that epithelia cells rest on

31
Q

Where do Alpha Catenins bind?

A

Directly to the Cytoplasmic Actin

32
Q

Fxn of Adherens

A
  • ANCHOR cells together
  • Reinforce integrity of tissue
  • Found on the Basolateral surface of Epithelial cells
33
Q

Ca2+ Dependent molecules

A
  • Cadherins

- Selectin

34
Q

Fxn of Gap Jxns

A
  • Molecular Pores that enable cells to rapidly exchange ions
  • Help coordinate activities

Molecular Biology Exam 2 (7 decks)

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