Cell Cycles. Mitosis & Meiosis, Karyotyping and Nondisjunction Flashcards

1
Q

What is the order of the cell cycle?

A

Interphase (G1, S Phase, G2)-> Mitosis-> Cytokinesis

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2
Q

What is the order of the cell cycle?

A

Interphase (G1, S Phase, G2)-> Mitosis-> Cytokinesis

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3
Q

What happens in interphase?

A

The cell appears to be at rest. G1, S Phase and G2 occur in interphase. The nucleus is NOT dividing. 90% of a cells life

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4
Q

What happens in G1?

A

Cell growth in size and mass, protein synthesis also occurs at this time.

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5
Q

What happens in S phase?

A

Synthesis phase is the replication of the cells DNA. Each chromosome is duplicated and is given a so-called “Chromatid”

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6
Q

What happens in G2?

A

The cell manufactures the materials which are needed form mitosis and protein in made

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7
Q

What are the differences between chromatin and chromosomes?

A

Chromatin: Non-condensed form of genetic material, long and stringy material in the nucleus (Cell is NOT dividing)
Chromosomes: short condensed double stranded genetic material (Cell is dividing)

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8
Q

What are the difference between chromosomes and chromatid?

A

Chromosomes: short condensed double stranded genetic material (Cell is dividing)
Chromatid: Single stranded genetic material -> the result of mitosis

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9
Q

What occurs in Prophase?

A

Chromatin condenses and become visible as chromosomes, fibres extend and attach to centromeres, centrioles move to opposite poles of cell, spindle fibres form, nucleus disappears

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10
Q

What is the order of mitosis?

A

Interphase-> prophase-> metaphase-> anaphase-> telophase. 10% of a cells life

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11
Q

What occurs in Prophase?

A

Chromatin condenses and become visible as chromosomes, fibres extend and attach to centromeres, centrioles move to opposite poles of cell, spindle fibres form, nucleus disappears

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12
Q

What occurs in Metaphase?

A

Spindle fibres align chromosomes alone metaphase plate,

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13
Q

What occurs in Anaphase?

A

Chromosomes are separated at centromeres, move to opposite poles, are now chromatids

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14
Q

What occurs in Telophase?

A

Chromatids arrive at opposite poles and become chromatins again, nucleoli form, spindle fibres disperse, cells pinch off into two, cytokinesis begins

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15
Q

What occurs in Cytokinesis in animals vs plants?

A

Animals: cleavage furrow forms which splits the cell in two
Plants: Cell plate forms and splits the cell in two

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16
Q

Sex Cell vs. Somatic Cell

A

Sex Cell: Is a sperm or egg cell that has 23 chromosomes, a Haploid. Which is represented by n
Somatic Cell: is any body cell that has 46 chromosomes, a Diploid. Which is represented by 2n

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17
Q

Sex Chromsome vs. Autosomes

A

Sex Chromsomes: is the xx=girl or the xy=boy this the the 23rd pair of chromosomes in an egg or sperm cell
Autosomes: is number 1-22 pairs of chromosomes that determine your traits like hair and eye colour

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18
Q

What does Ploidy mean?

A

The number of sets of chromosomes in a cell. If it is a gamete cell (egg or sperm) it would have 23 so the ploidy would be n or haploid. If it was a somatic cell it would have 46 so the ploidy would be 2n or diploid

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19
Q

What is Apoptosis and why would it occur?

A

Programmed cell death. It can occur because a cell doesn’t pass a certain checkpoint and G1, G2 or Mitosis or it can occur naturally like what an embryo gets rid of webbed fingers and feet, the cell dies automatically.

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20
Q

What phases of the cell cycle are most likely to be shortened in the cancerous skin cell?

A

Interphase (especially G1 & G2) are shortened because the cell is devoting more time to mitosis (division) and less time to normal actives.

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21
Q

What are telomeres?

A

They are caps at the end of chromosomes that limit the amount of times a cell can undergo division

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22
Q

What technologies can test for cancer? What are treatments for cancer?

A

CT scan, blood count, biopsy of a tumour, chest X-rays. Surgical removal of tumour, radiation, chemotherapy

23
Q

What are the advantages and disadvantages of asexual reproduction?

A

Advantages: Fast, less energy required, only need 1 parent
Disadvantages: No genetic diversity and can’t adapt to new environments

24
Q

What are homologous chromosomes?

A

1 homologous pair of chromosomes (2) can come in double stranded homologous chromosomes to become 4 (tetrad)

25
What is the order for meiosis?
Interphase-> Prophase 1-> Metaphase 1-> Anaphase 1-> Telophase 1 and Cytokinesis-> Prophase 2-> Metaphase 2-> Anaphase 2-> Telophase 2 and Cytokinesis
26
What happens in interphase of meiosis?
Chromsomes duplicate
27
What happens in Prophase 1 of meiosis?
Homologous chromosomes pair and exchange segments (crossing over) and sister chromatids intertwine to become tetrads
28
What happens in Metaphase 1 of meiosis?
Tetrads (4 strands) line up along the metaphase plate
29
What happens in Anaphase 1 of meiosis?
Tetrad pairs are split up into an individual chromosome with 2 strands
30
What happens in Telophase 1 and Cytokinesis of meiosis?
Two haploid (23 chromosomes) pinch off into two different cells. Chromosomes are still double stranded though
31
What happens in Prophase 2 of meiosis?
Fibres extend and attach to centromeres of the chromosomes, centrioles move to opposite poles of cell, spindle fibres form, nucleus disappears
32
What happens in Metaphase 2 of meiosis?
Chromosomes line up along the metaphase plate
33
What happens in Anaphase 2 or meiosis?
Chromosomes are split apart and are now called chromatids
34
What happens in Telophase 2 and Cytokinesis?
Haploid daughter cells form and become 4 cells each with 23 chromosomes
35
Mitosis vs Meiosis: Types od cells involved
Mitosis: Body cells (Somatic Cells) Meiosis: Germ or gamete cells (egg & sperm)
36
Mitosis vs Meiosis: Number of rounds of division in 1 cycle
Mitosis: 1 division Meiosis: 2 divisions
37
Mitosis vs Meiosis: Number of rounds of division in 1 cycle
Mitosis: 1 division Meiosis: 2 divisions
38
Mitosis vs Meiosis: Number of duplications of chromosomes
Mitosis: Chromosomes duplicate BEFORE cell division during S Phase of Interphase Meiosis: 1 duplication in interphase 1
39
Mitosis vs Meiosis: Number of cells resulting from 1 cycle
Mitosis: 2 cells w/ 46 chromosomes and identical to one another. Called Daughter Cells Meiosis: 4 cells w/23 chromosomes and not identical. Called Grand-Daughter Cells
40
Mitosis vs Meiosis: Chromosome number of parent cell
Mitosis: 2n= diploid cells (46 chromosomes) Meiosis: 2n= diploid cells (46 chromosomes)
41
Mitosis vs Meiosis: Chromosome number of resulting cells
Mitosis: 2n= diploid (46 chromosomes) Meiosis: n= haploid (23 chromosomes) - reducing the chromosome number in half
42
Mitosis vs Meiosis: Role of resulting cells
Mitosis: Regular body function, repair/ replace old/ dying cells, growth- using identical copies Meiosis: Sexual reproduction- gametes are made that will combine to make an embryo
43
Mitosis vs Meiosis: Function of division process (Purpose)
Mitosis: Make exact copies of parent cell and maintain chromosome number Meiosis: Make gametes unique, not identical to the parent in order to increase genetic diversity to help the off spring survive in a new environment
44
What is independent assortment?
How both the maternal (mom) and paternal (dad) line up on a metaphase plate in meiosis 1
45
What is random fertilization?
A random ovum fertilized by a random sperm
46
What are the disadvantages to sexual reproduction?
Slow, requires more energy than simple mitosis, 2 parent of the opposite sex
47
How do you make a karyotype?
Obtain a sample of a cell-> use a drug to stimulate mitosis-> use a drug to stop mitosis in interphase-> stain the cells w/ dye to get the banding pattern of chromosomes-> take a photo-> pair up the homologous chromosomes according to size and banding pattern-> arrange chromosomes from largest pair (#1) to the smallest pair (#22) and then the sex chromosomes (xx or xy)
48
What can karyotypes tell?
The sex of a fetus and whether or not there is an abnormal number of chromosome (an aneuploidy)
49
What ethical issue can arise by from knowing the sex of the fetus or an abnormality?
Some parents will abort the pregnancy if the baby is a female or if the fetus is not going to be born healthy which violates the right to life.
50
What is nondisjunction?
When chromosomes or chromatids do not operate as they should during meiosis or anaphase of mitosis
51
What is the notation for down syndrome and information for down syndrome: sex, chromosomes, type of aneuploidy
Notation: 47, +21, (xx or xy) Male or female Extra #21 chromsomes Trisomy 2n + 1=47
52
What would happen in a cell that anaphase 1 of meiosis did not occur correctly?
Homologous pairs of chromosomes do not separate correctly in Anaphase 1 and both chromosomes go to the same pole, leaving 2 gametes without genetic information
53
What would happen in a cell that anaphase 2 of meiosis did not occur correctly?
Chromosomes that separated from anaphase 1 would separate properly but in anaphase 1 the chromatids would not separate and both chromatids would move to the same pole