Cell Adhesion and Motility Flashcards
Filopodia
Thin, spike-like protrusions with an actin filament core, generally on the leading edge of a crawling animal cell
Lamelipodia
Flattened sheet-like protrusions supported by a meshwork of actin filaments, which is extended at the leading edge of a crawling cell
Pseudopodia
Large, thick cell-surface protrusions formed by ameboid cells as they crawl
Actin Regulators
- What 2 signaling molecules promote actin polymerization?
- What signaling molecule promotes myosin pushing from back of cell
- Rac and Cdc42
- Rho
Chemotaxis
Process whereby cells sense soluble molecules and follow them along a concentration gradient to their source
What family of receptors are most commonly triggered by chemotaxins?
GPCRs
What effect do Gi subunits have on cell migration?
What effect do Gs subunits have on cell migration?
Gi = stimulate cell migration
Gs = inhibit cell migration
What is cell polarization?
The tendency of migrating cells to have a distinc stable front and rear. This polarity araises from directional cues in environment.
Directional Cues
- Chemotactic
- Haptotactic
- Mechanotactic
- Electrotactic
- Durotactic
- Induced by chemoattractants
- Caused by varying concentrations of substrate
- Break down of cell-cell contacts
- Induced by electric field
- Due to differences in pliability
Protrusion is the formation of membrane extensions. What are the 3 major components of this action?
- Expand plamsa membrane
- Form scaffold that supports membrane expansion
- Establish contact with substratum
Adhesion
- Occurs via what receptors?
- What 2 things does adhesion link together?
- Integrins
- Actin cytoskeleton and extracellular marix (substratum)
- REMEMBER THESE ARE FOCAL ADHESIONS
