Cell Adhesion 1

Question 1

Your 18 month old patient is suffering from hypoglycemia with no indication that he suffers from DM, with a nonremarkable pancreas. No elevation within the A1C. When looking to the SGLT1 protein of the enterocyte, it was noticed to be displaced laterally; Which of the following is most likely to be affected?

A. Gap Junctions 
B. Zona Adhérents
C. Zona Occuldens 
D. Integrins 
E. Hemidesmosomes.

Answer 1

B. Zona Ocludens is known to be the answer as it restricts the movement of proteins.

STated Previous SGLT1 is known to be present within the apical surface of the enterocyte. As a result, the closest to the plasma membrane of the enterocyte is known to be tight junction or other wise known as zonula Ocludens

Question 2

Within heart muscle which of the ancohoring junctions is most prominent?

A. Desmosomes
B. Hemidesmosomes
C. Zonula Adherens
D. Gap Junctions

Answer 2

Zonula Adherns is the only anchoring junction listed furthermore cardiac muscle undergoes extreme stress and mechanical force. Therefore needing as much stabilization will the ability to work in syntia.

Question 3

Desmosomes are known for what type of Adhesion
?

A. Cell - Cell
B. Cell- ECM
C. Cell- Basal Lamina
D. Cell- Cytoskeleton

Answer 3

A. Cell- Cell Binding the Intermediate filaments within the cell

Question 4

While working within a lab, your manager is working on research on several disease in which has been known to effect structural proteins. More specifically the Hemi Desmosomes, which of the following characteristics would you expect to see to therefore differentiate between that and something else?

A. Round Shaped- Intergrin
B. Moon Shaped- Intergrin
C. Heart Shaped-Intermediate filament within the Explasmic portion of the the membrane
D. Moon Shaped- Connexin

Answer 4

B. Moon Shaped while connected to and intergrein molecule ancoring it from the intracellular via intermediate filaments. While anchoring it from the basement membrane via Laminin and Collagen

Question 5

While working within a lab, your manager is working on research on several disease in which has been known to effect structural proteins. More specifically the Hemi Desmosomes, which of the following characteristics would you expect to see to in a clinical setting?

A. Osler Nodes 
B. Lesions with hypothenar prominence 
C. Pus Pocket
D. Blistering of the Epidermis 
E. Parasternal Heaves

Answer 5

D. Blistering of the Epidermis as this common abnormality within hemidesmosomes is known to have a clinical manifestation of Dermalepiderrmal Separation