Celiac Disease Flashcards

1
Q

immune disorder that is triggered by an environmental agent (the gliadin component in gluten) in genetically predisposed individuals

A

celiac disease

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2
Q

Ethnic group primarily affected by celiac disease

A

northern Europeans

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3
Q

Serologic studies used to confirm the diagnosis of CD

A

IgA antibodies to gliadin and endomysium

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4
Q

Protein triggered by gluten and that controls gut permeability by prying apart the cells of the intestinal lining

A

zonulin

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5
Q

Classic presentation of celiac disease

A

steatorrhea, weight loss, vitamin deficiencies

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6
Q

Seen on small biopsy of patient with celiac disease

A

villous atrophy

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7
Q

T/F Patients with celiac’s disease show a decreased risk of breast cancer

A

true

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8
Q

Single preferred test for detection of CD

A

IgA anti-tissue transglutaminase (TTG)

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9
Q

If there is a high probability of the disease, but the IgA anti-tissue transglutaminase (TTG) comes back negative, what further tests can be ordered?

A

Total IgA or IgG-deaminated gliadin peptides (DGP)

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10
Q

What is the next step in the work-up in a patient found to have positive serology?

A

small bowel biopsy

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11
Q

Recommended test for individuals with low pretest probability (purely Chinese, Japanese, and Sub-Saharan African). Is also the most specific test.

A

IgA endomysial antibody test

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12
Q

What is the next step if the serology is positive but the small bowel biopsy is negative?

A

the patient can be put on high gluten diet and be rebiopsied after6-12 wks

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13
Q

Individuals who get diarrhea, feel “ILL” and bloated and find if they eliminate gluten from their diet they feel better

A

gluten sensitivity

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14
Q

presence of what IgA antibody is nearly pathognomonic for CD?

A

endomysium

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15
Q

Recognized incidentally based upon screening for antibodies. Often have some changes in mucosa of the small bowel. do NOT show clinical symptoms but may complain of fatigue

A

silent CD

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